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16 Cards in this Set
- Front
- Back
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What are the four malaria causing plasmodiums and which ones have a recurrent stage and which one is often drug resistane.
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falciparum, milariae, vivax, ovale. Vivax and ovale have recurrence ability by forming hypnozoites. Falciparum causes the most severe form and is frequently drug resistant.
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Ell areas except species whre chloroquine resistant falciparum is use what drug?
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Chloroquine.
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If you're in an area where P. falciparum is chloroquine resistant you should use what drug for prophylaxis?
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Malarone or mefloquine.
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Multidrug-resistant P. falciparum needs what drug.
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Doxycycline.
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Terminal prophylaxis of P. vivax and ovale?
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Primaquine after returning home to eradicate possible liver hyponozoites. Kills the hyponozoites. Different from other because the others prevent erythrocyte stage.
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P. vivax or P. ovale should have what drugs given.
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Chloroquine than primaquine.
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Uncomplicated Chloroquine-resistane P. falciparum use what?
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Quinine plus doxy or clinda
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Complicated P. falciparum use what
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Artesunate or qunidine
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Chloroquine
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Parasites consume hemoglobin in RBC. Heme is stored as hemozoin as it is toxic to the parasite. Chloroquine prevents hemozoin formation and heme becomes toxic to the cell. Don't give with psoriasis or porphyrria since it can give attacks.
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Mefloquine
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Unknown MOA. Causes neuropsychiatric problems.
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Primaquine
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Only drug effective against liver hypnozoites. Most potent inducer of hemolytic anemia in G-6-PDH people.
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Quinine/quinidine
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Optical isomers of each other. MOA unknown. Cinchonism-ringing of ears and balance problems.
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Atovaquone plus proguanil gives us Malarone
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Atovaquone disrupts electron transport. Proguanil is a prodrug that inhibits dihydrofolate reductase.
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Entamoeba hystolytic (amebiasis)
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Aysmptomatic give luminal amebicide, iodoquinol, or diloxanide furoate. If symptomatic give metronidazole plus luminal amebicide.
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Girardia lamblia treatment
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Metronidazole
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Trichomonas vaginalis treatment
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Metronidazole.
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