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25 Cards in this Set
- Front
- Back
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What are the class IA antiarrhythmic drugs?
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Queen Anne Proclaims Diso's Pyramid.
Quinidine, Amiodarone (class III mostly), Procainamide, Disopyramide |
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What is the MOA of the class IA drugs?
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Block the Na channel for stage 0. Increase ERP, Increase QT -> Torsades, INCREASE AP duration.
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What is the MOA of quinidine? What AEs does it cause?
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Class Ia. Also has class III effects.
QT prolongation -> Torsades HA, vertigo, tinnitus GI, bitter taste, bradycardia, asystole INCREASES digoxin levels Use for atrial, ventricular, paroxysmal ventricular contractions |
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What AE's foes procainamide cause? What else does it affect?
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Drug-induced lupus (HIPP)
QT prolongation (torsades) GI, rash, HYPOTENSION NAPA is a renally cleared active metabolite that affects K channels |
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What limits the use of disopyramide?
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Its anticholinergic effects
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What are the class Ib drugs?
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Little Timmy Makes Punch
Lidocaine, Tocainide, Mexilitine, Phenytoin |
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What is the MOA of the class Ib drugs?
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Slow repolarization of Na channels, REDUCE AP duration, work on ISCHEMIC tissue
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What is lidocaine used for? What AEs does it cause?
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Short term tx of ACUTE VENTRICULAR arrhythmias
Local anesthetic, short half-life Cardiac depression, CNS effects |
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What are the class Ic drugs?
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Encainide, Flecainide, Propafenone, (merocizine)
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What is the MOA of class Ic drugs? When are they used?
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SLOOOOW conduction velocity, no change in AP duration.
use for VENTRICULAR arrhythmias, LAST RESORT. |
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What is the MOA of class II AA drugs?
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Beta-blockers! Block Beta-adrenergic receptors and decrease cAMP
Decreases Ca currents, decreases slope of phase 4 (automaticity) SLOWS AV conduction |
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When are class II drugs used?
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beta-blockers!
A-fib! or prophylaxis of A fib after MI |
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What are the AEs of class II drugs?
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beta blockers!
Bronchospasm, fatigue, lethargy, impotence, decreased libido, masks sx's of hypoglycemia in DM.... |
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What is the MOA of class III drugs?
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Block outward K currents to PROLONG AP -> Torsades!
Use in A fib |
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What are the class III drugs?
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Sotalol, Amiodarone, Bretylium, Dofetilide, Ibutilide
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What is the MOA of sotalol? What are its uses?
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Class II at low doses (beta blocker!), Class III at higher doses -- 2 isomers
Use for life threatening V. TACH, also A flutter/fib <-- only for HOSPITAL use! |
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Where is solatolol CI?
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Class III and II!
asthmatics, COPD, CHF, abrupt withdrawal, heart block |
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What is the MOA of amiodarone?
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ALL 4 classes!! Increases ERP
Used for all, broad spectrum |
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What AEs does amiodarone cause? What should you check? What is its half life?
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PFTs, LFTs, TFTs
Pulm fibrosis, cirrhosis, AV block, hypotension, bradycardia, cataracts, hypo/hyperthyroidism! >75% pts! half-life 30-100 days, Least pro-arrhythymic! |
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What are dofetilide and ibutilide used for?
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Dofetilide: a fib maintenance, oral
Ibutilide: a fib/flutter conversio, IV, asses renal fcn in hospital TORSADES! (also severe LV dysfunction, bradycardia with ibutilide) |
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What are the class IV AA drugs?
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Ca channel blockers: verapamil and diltiazem! Increase conduction velocity, AVN
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What is the use of diltiazem?
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DOC for A fib, flutter. PO, IV.
May cause hypotension! |
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What is adenosine used for?
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Misc AA drug
DOC for dx and tx AVN arrhythymias, low toxicity |
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What is potassium's MOA and usage?
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Depresses ectopic pacemakers, good for digoxin/digitalis toxicity
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What is magnesium's MOA and usage?
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Depressant effects, good for digoxin/digitalis toxicity and Torsades!
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