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28 Cards in this Set
- Front
- Back
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What is ergonovine (mehtylergonovine) used for?
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Used to control postpartum hemorrhage
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What is Dinoprostone used for?
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PGE2 used for midtrimester abortions
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What is carboprost used for?
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PGF2a used for midtrimester abortions
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What is 15-methyl PGF2a used for?
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Tx of postpartum hemorrhage
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What is PGI2 used for
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Stimulates uterine blood flow and helps maintain a patent ductus arteriosus
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What is misoprostol used for?
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PGE1 analog that is under investigation as an abortifacient
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What is the drug of choice for inducing labor?
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Pitocin (oxytocin)
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What is pitocin used for?
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oxytocin - inducing labor
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What is the most powerful stimulus that induces release of ADH?
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Baroreceptors in the vasculature
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Where might one find V1a receptors?
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Vascular smooth muscle, adrenal glands, myometrium, and renal tissues
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Where might one find V2 receptors?
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Renal collecting-duct system, epithelial cells of the thick ascending limb, and vascular endothelial cells
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What are some of the effects once a V1 receptor is stimulated?
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-Contraction of mesangial cells
-vascular SM in vasa recta and efferent arterioles -stimulation of prostaglandin synthesis in medullary interstitial cells |
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What are some of the effects once a V2 receptor is stimulated?
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-The most potent response to vasopressin
-Various kidney stuff |
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What is Pitressin used for?
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a vasopressin analog; ADH-sensitive DI
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What is desmopressin used for?
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a vasopressin analog; ADH-sensitive DI
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What are some GI uses of V1 agonists?
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-Treat postop ileus and abdominal distension.
-Vasoconstriction of splanchnic vessels to treat esophageal varices -reduce hemorrhage during abdominal surgery -Reduce bleeding during acute hemorrhagic gastritis -combo with NE to manage vasodilatory shock |
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How are V2 agonists useful in type 1 von Willebrand's disease?
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Increase of von Willebrand factor?
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How are V2 agonists helpful in hemophilia A?
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Increase of factor VIII
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What would you use to Tx type 1 von Willebrand's disease?
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V2 agonist
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What would you use to Tx hemophilia A?
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V2 agonist
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What are the major adverse effects of vasopressin therapy?
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-Facial pallor
-Increased GI activity -Peripheral vasoconstriction -Water intoxication |
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How do NSAIDS (indomethacin) interact with vasopressins?
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Sensitizes the kidney to ADH by inhibiting prostaglandin synthesis
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What other drugs increase the actions of ADH?
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Carbamazepine and chlorpropamide
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What drugs inhibit the effects of ADH
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Lithium and Demeclocycline
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Why do ethanol and phenytoin make you pee?
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Inhibition of ADH leading to diuresis
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What effect do ergot alkaloids have on the uterus?
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All of the alkaloids increase the motor activity of the uterus.
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What can be administered to counteract tetanus uterine contractions?
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Terbutaline
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What CCB can be used in pregnancy in why? Basically, I'm asking you to tell me everything.
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Nifedipine is commonly used in preterm labor to relax the myometrium and attenuate oxytocin-induced contractions.
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