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47 Cards in this Set
- Front
- Back
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PCN toxicity
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Seizures
(esp. poor renal function) |
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Penicillin G
how to give it |
always (i.v.) --> acid labile
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Penicillin G
Uses |
DOC
Strep SSTI B-hemolytic strep Neurosyphillis Neisseria meningittidis |
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Penicillin G
Cross-Resistance |
3rd generation cephalosporins won't work either
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Procaine PenG
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DOC prophylaxis for Strep.
(also benzathine) i.m. injection |
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Benzathine PenG
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DOC 1' and 2' syphyllis
DOC prophylaxis Strep. i.m. |
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B-lactamase resistant PCNS
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oxacillin & nafacillin (i.v.)
DOC (inpatient) SSTI MSSA ($$$) |
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DOC outpatient SSTI MRSA
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p.o. clindamycin
p.o. doxycylin p.o. trim-sulfa |
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B-lactamase inhibitors
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Clauvanate
Sulbactam Aztreobactam |
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Clauvanate S/E
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diarrhea
(pair w/ amoxicillin) |
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B-lactamase inhibitor w/ S/E
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CLauvanate= diarrhea
(amoxicillin- clauvanate) |
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Extednded Spectrum PCNs
Method of Admin. |
Amoxicillin (p.o.)
Ampicillin (i.v.) |
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Ampicillin DOC for....
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Listeria
(i.v. due to diarrhea) |
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Benefits of extended spectrum antibiotics
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(amoxicillin po + ampicillin iv)
better able to penetrate Gram (-) -Listeria (ampicillin) -H. flu |
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Antipseudomonal PCNs
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Ticarcillin
Piperacillin (best) |
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Broadest spectrum PCN
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Piperacillin
DOC: diabetic ulcers febrile neutropenia (+vanc) Pseudomonas HA/VA Pneumonia (+ vanc) |
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How to give piperacillin
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i.v.
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DOC otitis media
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ampicillin
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What is azetoram used for?
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Carbanems
severe Gram (-) infections w/ PCN allergy last resort if fail tx w/ i.v. cefepime or pip-tazo |
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Carbapanems and PCN allergy
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good generally but 15% may cross react
last resort drugs |
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Azetoram Administration
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i.v.
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Cephalosporins and B-lactamase
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kinda resistant
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1 Generation Cephalosporins
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Cefazolin
Cephalexin |
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1 Generation Cephalosporins
Uses |
surgical prophylaxis (non-GI)
SSTI MSSA (inpatient) real world i.v. cefazolin SSTI MSSA (outpatient) p.o. cephalexin |
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cellulitis MSSA inpatient
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i.v. cefazolin (real world)
i.v. nafacillin or oxacillin ($$$) |
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2' Generation Cephalosporins
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Cefoxitin (i.v.)
Cefotetan (i.v.) DOC GI surgical prophylaxis |
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p.o. cefedinir
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DOC otitis media
(w/ amoxicilli +/- clauvanate) |
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3' Generation Cephalosporins
Pseudomonas |
Ceftazidime
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Cephalosporin killing Pseudomonas
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Ceftazidime
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Whats great about Ceftazidime?
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3' Generation Cephalosporins
kills Pseudomonas |
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Azetoram Administration
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i.v.
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Cephalosporins and B-lactamase
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kinda resistant
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1 Generation Cephalosporins
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Cefazolin
Cephalexin |
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1 Generation Cephalosporins
Uses |
surgical prophylaxis (non-GI)
SSTI MSSA (inpatient) real world i.v. cefazolin SSTI MSSA (outpatient) p.o. cephalexin |
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cellulitis MSSA inpatient
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i.v. cefazolin (real world)
i.v. nafacillin or oxacillin ($$$) |
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2' Generation Cephalosporins
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Cefoxitin (i.v.)
Cefotetan (i.v.) DOC GI surgical prophylaxis |
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p.o. cefedinir
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DOC otitis media
(w/ amoxicilli +/- clauvanate) |
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3' Generation Cephalosporins
Pseudomonas |
Ceftazidime
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Cephalosporin killing Pseudomonas
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Ceftazidime
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Whats great about Ceftazidime?
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3' Generation Cephalosporins
kills Pseudomonas |
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Ceftaroline = Awesome
Because |
kills MRSA
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MRSA w/ Gram (-) infection
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Ceftarzoline
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Cephalosporin excreted via hepatics:
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Ceftriaxone
all others monitor renal fxn |
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big risk w/ Cephalosporins
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renal damage (except Ceftriaxone)
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Seizurecillin
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Imipenem
give w/ cilastatin for DHP inhibition |
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trends Generation Cephalosporins
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increasing Gram (-) coverage
4th= Pseudomonase coverage decent (also Ceftazdime) |
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Best Generation Cephalosporins
Anaerobes |
2' Generation Cephalosporins
Cefoxitin Cefotetan |
