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27 Cards in this Set
- Front
- Back
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Morphine
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Full Agonist (u receptor)
Uses: severe pain Adverse: tolerance, sedation, drowsy, confused, dizzy, itching, sweating, constipation, addiction |
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Hydromorphone
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Full Agonist (u receptor)
Uses: severe pain Adverse: tolerance, sedation, drowsy, confused, dizzy, itching, sweating, constipation, addiction |
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Oxymorphone
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Full Agonist (u receptor)
Uses: severe pain Adverse: tolerance, sedation, drowsy, confused, dizzy, itching, sweating, constipation, addiction |
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Heroin
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Full Agonist
*Converted to 6-MAM, then morphine enters brain Adverse: tolerance, sedation, drowsy, confused, dizzy, itching, sweating, constipation, addiction |
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Meperidine
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Full Agonist (u receptor)
*Not used for pain due to toxic metabolite (normeperidine) Adverse: Large doses – tremors, muscle twitches, dilated pupils, hyperactive reflex, convulsions Contraindiction: MAO inhibs leads to serotonin syndrome (delirium, hyperthermia, headache, coma, death) |
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Fentanyl
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Full Agonist (u receptor)
*rapid onset/short duration **100x more potent then morphine |
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Sufentanil
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Full Agonist (u receptor)
*rapid onset/short duration **1000x more potent then morphine |
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Alfentanil
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Full Agonist (u receptor)
*rapid onset/short duration **1000x more potent then morphine |
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Remifentanil
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Full Agonist (u receptor)
*rapid onset/short duration **1000x more potent then morphine |
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Methadone
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Full Agonist (u receptor)
Uses: Detox in heroin pts, chronic pain Adverse: QT prolongation, torsades de pointes, death |
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Codeine
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Mold-Moderate Agonists
Uses: Analgesic (CYP2D6 converts to morphone), Antitussive (receptor bind codeine) *used w/ aspirin, acetaminophen, others |
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Oxycodone
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Mold-Moderate Agonists
Uses: Analgesic *used w/ aspirin, acetaminophen, others |
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Hydrocodone
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Mold-Moderate Agonists
Uses: Analgesic *used w/ aspirin, acetaminophen, others |
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Propoxyphene
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Mild-Moderate Agonists
Uses: Analgesic (dextra), Antitussive (levo isomer) Adverse: Seizures, cardiac conduction abnormalities Contra: elderly |
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Tramadol
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Mold-Moderate Agonists
*weak u receptor agonist Uses: Neuropathic pain Adverse: Seizures Contra: serotenergic drugs leads to serotonin syndrome |
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Pentazocine
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Mixed Agonist-Antagonist
*k agonist, u antag/part ag Uses: analgesic in opioid naive pts Adverse: Psychomimetic effects Contra: those on pure agonists -> can cause withdrawal rxn *has ceiling effect |
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Butorphanol
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Mixed Agonist-Antagonist
*k agonist, u antag/part ag Uses: analgesic in opioid naive pts Adverse: Psychomimetic effects Contra: those on pure agonists -> can cause withdrawal rxn *has ceiling effect |
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Nalbuphine
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Mixed Agonist-Antagonist
*k agonist, u antag Uses: analgesic in opioid naive pts Adverse: Psychomimetic effects Contra: those on pure agonists -> can cause withdrawal rxn *has ceiling effect |
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Buprenorphine
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Mixed Agonist-Antagonist
*u partial agonist, k antagonist Uses: Opioid addiction Adverse: NO Psychomimetic effects Contra: those on pure agonists -> can cause withdrawal rxn *has ceiling effect |
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Naloxone
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Opioid Antagonists
*antagonist at u, k, sigma Uses: acute opioid overdose |
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Naltrexone
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Opioid Antagonists
*antagonist at u, k, sigma Uses: Opioid addiction |
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Nalmefene
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Opioid Antagonists
*antagonist at u, k, sigma Uses: Alcoholics: decrease craving for alcohol |
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Dextrometorphan
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Antitussive
Uses: cough suppressant |
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Levopropoxyphene
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Antitussive
Uses: cough suppressant |
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Noscapine
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Antitussive
Uses: cough suppressant |
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Diphenoxylate
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Antimotility drugs
*u, sigma recep on enteric nerves Uses: Diarrhea |
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Loperamide
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Antimotility drugs
*u, sigma recep on enteric nerves Uses: Diarrhea |
