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7 Cards in this Set
- Front
- Back
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What are the endogenous opioid peptides?
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-Enkephalins
-Beta-endorphin -Dynorphin |
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What are opioid receptors?
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Mu, delta, kappa
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What are the opioid receptors' MOA?
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-All are coupled to GPRCs
-All subtypes close voltage-gated Ca2+ channels on presynaptic nerve terminals -Mu receptors also open K+ channels which inhibit nerve transmission |
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What are the effects of Mu receptor stimulation?
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-Analgesia
-Euphoria -Sedation -Side effects associated with opioids |
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What are the effects of Kappa receptor stimulation?
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Analgesia in some ppl, dysphoria in others
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To what opioid effects can we develop tolerance?
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-Analgesia
-Sedation -Euphoria -Nausea/vomiting -Resp depression |
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What opioid effects do we not develop tolerance to?
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-Constipation
-Miosis -SZ |
