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50 Cards in this Set
- Front
- Back
- 3rd side (hint)
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Nitrate free intervals are needed due to
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Decrease Tolerance
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SE of nitrates (4)
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Postural hypotension, reflex tachycardia,
hot flashes, and throbbing headache due to meningeal artery dilation |
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CCB are DOC for
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Prinzmetal's angina
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Beta blockers are used for which type of anginal attack
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Classic
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Drugs used to treat CHF
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MOA of Cardiac glycosides (eg. digoxin)
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Indirectly increase intracellular calcium and cardiac contractility by inhibiting Na+/K+ ATPase
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Digoxin is used in (2)
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Atrial fibrillation and CHF
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Digoxin toxicity can be precipitated by
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Hypokalemia
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Antidote for digoxin toxicity
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Digibind
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Phosphodiesterase inhibitors that increase mortality and have been found to have NO beneficial effects (2)
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Amrinone and milrinone
Amir's Mill benefits None |
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SE of amrinone
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Thrombocytopenia
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Beta 1 agonists used in acute CHF
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Dobutamine and dopamine
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Diuretics work in CHF by
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Reducing preload
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Beta blockers work in CHF by
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Reducing progression of heart failure (never use in acute heart failure)
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Peptide drug used to treat CHF
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Nesiritide (BNP)
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MOA of nesiritide
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Increasing sodium excretion and decreases arterial and venous tone
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SE of nesiritide (2)
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Excessive hypotension and kidney failure
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"Nephiritide"
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Agent used in CHF that is a selective alpha and nonselective beta blocker
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Carvedilol
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Agent used in acutely decompensated CHF resembling natriuretic peptide
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Nesiritide (Natrecor)
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Drugs used in coagulation disorders
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Vitamin K dependent anticoagulant
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Warfarin (PT)
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Warfarin is contraindicated in
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Pregnancy
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Anticoagulant of choice in pregnancy
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Heparin
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Heparin (PTT) increases activity of
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Antithrombin 3
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Route of administration of warfarin
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Oral
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Routes of administration of heparin
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IV and IM (only LMW)
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SE of both warfarin and heparin
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Bleeding
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SE of heparin
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Heparin induced thrombocytopenia (HIT)
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Alternative anticoagulant used if HIT develops
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Lepirudin
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Antidote to reverse actions of warfarin
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Vitamin K or fresh frozen plasma
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Antidote to reverse actions of heparin
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Protamine sulfate
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MOA of aspirin
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Irreversibly blocking cyclooxygenase
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Agents used to treat MI and to reduce incidence of subsequent MI (2)
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Aspirin, metoprolol (Lopresor)
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SE of Aspirin
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GI bleeding
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Antiplatelet drug reserved for patients allergic to aspirin
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Ticlopidine
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SE for ticlopidine (2)
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Neutropenia and agranulocytosis
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Effective in preventing TIA's (2)
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Clopidogrel and ticlopidine
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Prevents thrombosis in patients with artificial heart valve
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Dipyridamole
think: valve is upside down pyramid |
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Block glycoprotein IIb/IIIa involved in platelet cross-linking (3)
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Abciximab, tirofiban and eptifibatide
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MOA of thrombolytics
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Degradation of fibrin clots and are administered IV
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Thrombolytics are used for (2)
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Pulmonary embolism and DVT
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Thrombolytic that can cause allergic reaction
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Streptokinase
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Thrombolytic used for acute MI and ischemic (non hemorrhagic) CVA
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Tissue plasmin activator
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SE of tPA
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Cerebral hemorrhage
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Antidote for thrombolytics
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Aminocaproic acid
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Agents used in anemias and hematopoietic growth factors
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Agent to treat hypochromic microcytic anemias
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Ferrous sulfate
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Chelating agent used in acute iron toxicity
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Deferoxamine
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Agent for pernicious anemia
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Cyanocobalamin (Vit B12)
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