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50 Cards in this Set
- Front
- Back
This beta blocker is the longest acting
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Nadolol
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These beta blockers are less lipid soluble
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Acebutolol and atenolol
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This beta blocker is highly lipid soluble and may account for side effects such as nightmares
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Propranolol
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Clinical uses of these agents include treatment of HTN, angina, arrhythmias, chronic CHF, and selected post MI patients
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Beta blockers
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Toxicity of these agents include bradycardia, AV blockade, exacerbation of acute CHF; signs of hypoglycemia may be masked (tachycardia, tremor, and anxiety)
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Beta blockers
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Glaucoma (all agents topical except for diuretics)
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Cholinomimetics that increase outflow, open trabecular meshwork, and cause ciliary muscle contraction (3)
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Pilocarpine, carbachol, physostigmine
PCP |
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Nonselective alpha agonists that increases outflow, probably via the uveoscleral veins (2)
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Epinephrine, dipivefrin
uveosclero - vefrine |
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Selective alpha agonists that decreases aqueous secretion (2)
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Apraclonidine, brimonidine
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These Beta blockers decrease aqueous secretion
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Timolol (nonselective), betaxolol (selective)
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This diuretic decreases aqueous secretion due to lack of HCO3- ion. Causes drowsiness and paresthesias, alkalinization of the urine may precipitate calcium salts, hypokalemia, acidosis
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Acetazolamide
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This prostaglandin causes increased aqueous outflow
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Prostaglandin PGF2a
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Antihypertensive Agents
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Inhibit angiotensin-converting enzyme (ACE)
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ACE inhibitors
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Captopril and enalapril (-OPRIL ending) are
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ACE inhibitors
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SE of ACE inhibitors (2)
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Dry cough, hyperkalemia
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ACE inhibitors are contraindicated in (2)
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pregnancy and with K+
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Losartan and valsartan block
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Angiotensin receptor
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Angiotensin receptor blockers do NOT cause
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Dry cough
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Agents that block L-type calcium channel
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Calcium channel blockers
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CCB contraindicated in CHF
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Verapamil
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CCB with predominate effect on arteriole dilation
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Nifedipine
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SE of CCB (3)
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Constipation, edema, and headache
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Agents that reduce heart rate, contractility, and O2 demand
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Beta-blockers
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Subset of B-blockers that are more cardioselective
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Beta-1 selective blockers
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Cardioselective Beta 1-blockers
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Atenolol, acebutolol, and metoprolol
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Beta-blockers should be used cautiously in (3)
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Asthma (bronchospastic effects),
diabetes (block signs of hypoglycemia) and peripheral vascular disease |
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Non-selective Beta-blocker also used for migraine prophylaxis
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Propranolol
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SE of beta blockers (4)
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Bradycardia, SEXUAL DYSFUNCTION,
decrease in HDL, and increase in Triglycerols (TG) |
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Alpha 1selective blockers (3)
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Prazosin, terazosin and doxazosin (-AZOSIN ending)
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Non-selective alpha1 blocker used to treat pheochromocytoma
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Phenoxybenzamine
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For rebound HTN from rapid clonidine withdrawal
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Phentolamine
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A1a-selective blocker with no effects on HTN used for BPH
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Tamsulosin (Flomax)
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SE of alpha blockers
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Orthostatic hypotension (especially with first dose) and reflex tachycardia
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Presynaptic Alpha 2 agonists used in HTN, and acts centrally (2)
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Clonidine, and methyldopa
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SE of methyldopa (2)
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Positive Comb's test, depression
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Methyldopa is contraindicated in
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Geriatrics due to its CNS (depression) effects
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SE of clonidine (3)
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Rebound HTN, sedation, dry mouth
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Direct vasodilator of arteriolar smooth muscle
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Hydralazine
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SE of hydralazine
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Lupus-like syndrome
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Arterial vasodilator that works by opening K+ channels
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Minoxidil
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SE of minoxidil
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Hypertrichosis
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IV Drug used Hypertensive Crisis
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Nitroprusside
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Nitroprusside vasodilates
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Arteries and veins
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Toxicity caused by nitroprusside and treatment
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Cyanide toxicity treated with sodium thiosulfate
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Diuretics
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Carbonic anhydrase inhibitor
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Acetazolamide
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Diuretic used for mountain sickness and glaucoma
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Acetazolamide
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SE of acetazolamide (5)
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Paresthesias, encephalopathy in patients with hepatic impairment,
acidosis, alkalinization of the urine (which may ppt. Ca salts), and hypokalemia |
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MOA of loop diuretics
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inhibits Na+/K+/2Cl- cotransport
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