Pharm Oneliners Sets Of 50 Part 9-2

Front 1

TCA used in obsessive compulsive disorder (OCD), most significant of TCA's for risk of seizure, weight gain, and neuropsychiatric signs and symptoms

Back 1

Clomipramine

Front 2

Secondary amines that have less sedation and more excitation effect

Back 2

Nortriptyline, Desipramine

Front 3

Side effects seen with tricyclic antidepressants (4)

Back 3

Muscarinic blockade (dry mouth, constipation);
weak alpha-1 block (orthostatic hypotension);
weak histamine block (sedation)

Front 4

Heterocyclics

Front 5

Antidepressant associated with neuroleptic malignant syndrome

Back 5

Amoxapine

A malignant antidepressant, a Mox on both your houses

Front 6

Antidepressant associated with seizures and cardiotoxicity

Back 6

Maprotiline

seizing all over the map

Front 7

Antidepressant having stimulant effects similar to SSRI's and can increase blood pressure

Back 7

Venlafaxine

Front 8

Antidepressant inhibiting norepinephrine, serotonin, and dopamine reuptake

Back 8

Venlafaxine

ven diagram - gets all three

Front 9

Antidepressant also used for sleep that causes priapism

Back 9

trazodone

trazoBONE

Front 10

Antidepressant which is inhibitor of CYP450 enzymes and may be associated with hepatic failure

Back 10

Nefazodone

Front 11

Heterocyclic antidepressants least likely to affect sexual performance, used for management of nicotine withdrawal, SE's include dizziness, dry mouth, aggravation of psychosis, and seizures

Back 11

Bupropion

Front 12

Antidepressant with MOA as alpha 2 antagonist, has effects on both 5-HT and NE, blocks histamine receptors, and is sedating

Back 12

Mirtazapine

Front 13

SE of mirtazapine

Back 13

Liver toxicity, increased serum cholesterol

Taz got a Fatty Liver

Front 14

Selective serotonin reuptake inhibitors (SSRI)

Front 15

Except for these agents all SSRI have significant inhibition of CytP450 enzymes

Back 15

Citalopram and its metabolite escitalopram

Front 16

Side effects frequently seen with SSRIs

Back 16

CNS stimulation; GI upset

Front 17

Antidepressants with no effect on BP, no sedation

Back 17

SSRIs

Front 18

SSRI with long T1/2 and can be administered once weekly for maintenance, not acute tx

Back 18

Fluoxetine

Front 19

SSRI indicated for premenstrual dysphoric disorder

Back 19

Fluoxetine (Sarafem)

Front 20

Some of SSRIs' therapeutic effects beside depression (5)

Back 20

Panic attacks, social phobias, bulimia nervosa, and PMDD (premenstrual dysphoric disorder), OCD

Front 21

SSRI less likely to cause a withdrawal syndrome

Back 21

Fluoxetine

Front 22

Opioid Analgesics & Antagonists

Front 23

Inhibit synaptic activity of primary afferents and spinal cord pain transmission neurons

Back 23

Ascending pathways

Front 24

Activation of these receptors close Ca2+ ion channels to inhibit neurotransmitter release

Back 24

Presynaptic mu, delta, and kappa receptors

Front 25

Activation of these receptors open K+ ion channels to cause membrane hyperpolarization

(Targeted by opioids)

Back 25

Postsynaptic Mu receptors

Front 26

Tolerance to all effects of opioid agonists can develop except (2)

Back 26

Miosis and constipation

Front 27

All opioids except this agent (which has a muscarinic blocking action) cause pupillary constriction

Back 27

Meperidine

Front 28

SE of these drugs include dependence, withdrawal syndrome, sedation, euphoria, respiratory depression nausea and vomiting, constipation, biliary spasm, increased ureteral and bladder tone, and reduction in uterine tone

Back 28

Opioid Analgesics

Front 29

Strong opioid agonists

Back 29

Morphine, methadone, meperidine, and fentanyl

Front 30

Opioids used in anesthesia

Back 30

Morphine and fentanyl

Front 31

Opioid used in the management of withdrawal states

Back 31

Methadone

Front 32

Opioid available trans-dermally

Back 32

Fentanyl

Front 33

Opioid that can be given PO, by epidural, and IV, which helps to relieve the dyspnea of pulmonary edema

Back 33

Morphine

Front 34

Use of this opioid with MAOI can lead to hyperpyrexic coma, and with SSRI's can lead to serotonin syndrome

Back 34

meperidine (Demerol)

Front 35

Moderate opioid agonists

Back 35

Codeine, hydrocodone, and oxycodone

Front 36

Weak opioid agonist, poor analgesic, its overdose can cause severe toxicity including respiratory depression, circulatory collapse, pulmonary edema, and seizures

Back 36

Propoxyphene

Front 37

Partial agonist or mixed antagonists

Front 38

Partial opioid agonist, considered a strong analgesic, has a long duration of action and is resistant to naloxone reversal

Back 38

Buprenorphine

Front 39

Opioid antagonist that is given IV and had short DOA

Back 39

Naloxone

Front 40

Opioid antagonist that is given orally in alcohol dependency programs

Back 40

Naltrexone

Front 41

These opioid agents are used as antitussive

Back 41

Dextromethorphan, Codeine

Front 42

These agents are used as antidiarrheal

Back 42

Diphenoxylate, Loperamide

Front 43

Drugs of Abuse

Front 44

Abused Inhalant anesthetics (3)

Back 44

NO, chloroform, and diethyl ether

Front 45

Abused drugs: Toxic to the liver, kidney, lungs, bone marrow, peripheral nerves, and cause brain damage in animals, sudden death has occurred following inhalation (2)

Back 45

Fluorocarbons and Industrial solvents

Front 46

Abuse of theses cause dizziness, tachycardia, hypotension, and flushing

Back 46

Organic nitrites

Front 47

Causes acne, premature closure of epiphyses, masculinization in females, hepatic dysfunction, MI, and increases in libido and aggression

Back 47

Steroids

Front 48

Readily detected markers that may assist in diagnosis of the cause of a drug overdose include (7)

Back 48

Changes in heart rate, blood pressure, respiration, body temperature, sweating, bowel signs, and pupillary responses

Vitals(4) + pupils, sweating and bowels

Front 49

Opioid Analgesics

Front 50

Opioids most commonly abused by health care professionals (5)

Back 50

Heroin, morphine, oxycodone, meperidine and fentanyl