Pharm Oneliners Sets Of 50 Part 5

Front 1

Increase bone density, also being tested for breast CA prophylaxis

Back 1

Raloxifene (SERM-selective estrogen receptor modulator)

Front 2

Used intranasally and decreases bone resorption

Back 2

Calcitonin (salmon prep)

Front 3

Used especially in postmenopausal women, dosage should be 1500 mg

Back 3

Calcium

Front 4

Vitamin given with calcium to ensure proper absorption

Back 4

Vitamin D

Front 5

Drugs with important actions on smooth muscle

Front 6

Disease caused by excess ergot alkaloids

Back 6

St. Anthony's Fire

Front 7

Endogenous substances commonly interpreted as histamine, serotonin, prostaglandins, and vasoactive peptides

Back 7

Autocoids

Front 8

Syndrome of hypersecretion of gastric acid and pepsin usually caused by gastrinoma; it is associated with severe peptic ulceration and diarrhea

Back 8

Zollinger-Ellison Syndrome

Front 9

Drug that causes contraction of the uterus

Back 9

Oxytocin

Front 10

Distribution of histamine receptors H1, H2, and H3

Back 10

Smooth muscle; stomach, heart, and mast cells; nerve endings, CNS respectively

Front 11

Prototype antagonist of H1 and H2 receptors (2)

Back 11

Diphenhydramine and cimetidine, respectively

Front 12

1st generation antihistamine that is highly sedating

Back 12

Diphendydramine

Front 13

1st generation antihistamines that are least sedating (2)

Back 13

Chlorpheniramine or cyclizine

Front 14

2nd generation antihistamines (3)

Back 14

fexofenadine, loratadine, and cetirizine
Allegra, Claritin, Zyrtec

Front 15

Generation of antihistamine that has the most CNS effects

Back 15

First generation due to being more lipid-soluble

Front 16

Major indication for H1 receptor antagonist

Back 16

Use in IgE mediated allergic reaction

Front 17

Antihistamine that can be used for anxiety and insomnia and is not addictive

Back 17

hydroxyzine (Atarax)

Front 18

H1 antagonist used in motion sickness (3)

Back 18

Dimenhydrinate, meclizine, and other 1st generation

Front 19

Most common side effect of 1st generation antihistamines

Back 19

Sedation

Front 20

Lethal arrhythmias resulting from concurrent therapy with azole fungals (metabolized by CYP 3A4) and these antihistamines which inhibit the 3A4 iso-enzyme.

Back 20

Terfenadine and astemizole (have been removed from the market)

aSTEMIzole

Front 21

H2 blocker that causes the most interactions with other drugs

Back 21

Cimetidine

Front 22

Clinical use for H2 blockers

Back 22

Acid reflux disease, duodenal ulcer and peptic ulcer disease

Front 23

Receptors for serotonin (5HT-1) are located where?
What do they do?

Back 23

Mostly in the brain, and they mediate synaptic inhibition via increased K+ conductance

Front 24

5HT-1d agonist used for migraine headaches (3)

Back 24

Sumatriptan, naratriptan, and rizatriptan

Front 25

Triptan available in parenteral and nasal formulation

Back 25

Sumatriptan

Front 26

H1 blocker that is also a serotonin antagonist

Back 26

Cyproheptadine

Front 27

Agents for reduction of postpartum bleeding (3)

Back 27

Oxytocin, ergonovine and ergotamine

Front 28

Agents used in treatment of carcinoid tumor (3)

Back 28

Ketanserin, cyproheptadine, and phenoxybenzamine

Front 29

5HT-3 antagonist used in chemotherapeutic induced
emesis (4)

Back 29

Ondansetron, granisetron, dolasetron, alosetron

Front 30

5HT-3 antagonist that has been associated with QRS and QTc prolongation and should not be used in patients with heart disease

Back 30

Dolasetron

Front 31

DOC to treat chemo-induced nausea and vomiting

Back 31

Odansetron

Front 32

Drug used in ergot alkaloids overdose, ischemia and gangrene

Back 32

Nitroprusside

Front 33

Reason ergot alkaloids are contraindicated in pregnancy

Back 33

Uterine contractions

Front 34

SE of ergot alkaloids

Back 34

Hallucinations resembling psychosis

Front 35

Ergot alkaloid used as an illicit drug

Back 35

LSD

Front 36

Dopamine agonist used in hyperprolactinemia

Back 36

Bromocriptine

Front 37

Peptides causing increased capillary permeability and edema (2)

Back 37

Bradykinin and histamine

Front 38

Mediator of tissue pain, edema, inactivated by ACE, and may be a contributing factor to the development of angioedema

Back 38

Bradykinin

Front 39

Drug causing depletion of substance P (vasodilator)

Back 39

Capsaicin

Front 40

Prostaglandins that cause abortions

Back 40

Prostaglandin E1 (misoprostol) PGE2, and PGF2alpha

Front 41

Difference between COX 1 and COX 2

Back 41

COX 1 is found throughout the body and COX 2 is only in inflammatory tissue

Front 42

Drug that selectively inhibits COX 2

Back 42

Celecoxib and rofecoxib

Front 43

Inhibitor of lipoxygenase

Back 43

zileuton (Zyflo)

Front 44

Major SE of zileuton

Back 44

Liver toxicity

Front 45

Inhibitor of leukotrienes (LTD4) receptors and used in asthma

Back 45

Zafirlukast and montelukast

Front 46

Used in pediatrics to maintain patency of ductus arteriosis

Back 46

PGE1

Front 47

Prostaglandin approved for use in severe pulmonary HTN

Back 47

PGI2 (epoprostenol)

Front 48

Prostaglandin used in the treatment of impotence

Back 48

Alprostadil (PGE1)

Front 49

Irreversible, nonselective COX inhibitor

Back 49

Aspirin

Front 50

Class of drugs that reversibly inhibit COX

Back 50

NSAIDS