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27 Cards in this Set

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MOA of NSAIDS
inhibit prostaglandin synthesis by inhibiting cyclo-oxygenase (cox)
Difference between aspirin and other NSAIDS
Aspirin irreversibly inhibits cyclooxygenase
Four main actions of NSAIDS
Anti-inflammatory, analgesia, antipyretic and antiplatelet activity
Agent used for closure of patent ductus arteriosus
Indomethacin
Aspirin is contraindicated in children with viral infection
Potential for development of Reye's syndrome
SE of salicylates
Tinnitus, GI bleeding
NSAID also available as an ophthalmic preparation
Diclofenac
NSAID available orally, IM and ophthalmically
Ketoralac
NSAID that is used for acute condition, such as pre-op anesthesia and has limited duration (<5 days) of use due to nephrotoxicity
Ketoralac
Newer NSAID that selectively inhibits COX-2
Celecoxib
COX 2 inhibitors may have reduced risk of
Gastric ulcers and GI Bleeding
COX 2 inhibitors should be used cautiously in pts with
Pre-existing cardiac or renal disease
Acetaminophen only has
Antipyretic and analgesic activity
SE of acetaminophen
Hepatotoxicity
Antidote for acetaminophen toxicity
N-acetylcysteine
DMARDs are slow acting drugs for
Rheumatic disease
MOA of gold salts
Alter activity of macrophages and suppress phagocytic activity of PMNs
SE of gold salts
Dermatitis of the mouth aplastic anemia and agranulocytosis
Causes bone marrow suppression
Methotrexate
SE of penicillamine
Aplastic anemia and renal
Interferes with activity of T-lymphocytes
Hydroxychloroquine
Anti-malarial drug used in rheumatoid arthritis (RA)
Hydroxychloroquine
SE of hydroxychloroquine
Retinal destruction and dermatitis
MOA of Leflunomide (newer agent)
Inhibiting Dihydroorotate Dehydrogenase which leads to decreased pyrimidine synthesis
Proteins that prevent action of tumor necrosis factor alpha (TNF-alpha)
Infliximab and etanercept
Anti-rheumatic agent also used for ulcerative colitis
Sulfasalazine
Anti-rheumatic agent also used for Chron's disease
Infliximab