Pharm One-Liners Week 5

Front 1

SE seen only in men with administration of ketoconazole

Back 1

Gynecomastia

Front 2

Topical DOC in impetigo

Back 2

Topical mupirocin (Bactroban)

Front 3

DOC for influenza A

Back 3

Amantadine

Front 4

DOC for RSV

Back 4

Ribavirin

Front 5

DOC for CMV retinitis

Back 5

Ganciclovir

Front 6

SE for ganciclovir

Back 6

Neutro, leuko and thrombocytopenia

Front 7

Anti-viral agents associated with Stephen Johnson syndrome

Back 7

Nevirapine, amprenavir

Front 8

HIV antiviral class known to have severe drug interactions by causing inhibition of metabolism

Back 8

Protease inhibitors

Front 9

Antivirals that are teratogens

Back 9

Delavirdine, efavirenz, and ribavirin

Front 10

Antivirals associated with neutropenia

Back 10

Ganciclovir, zidovudine, saquinavir, and interferon

Front 11

HIV med used to reduce transmission during birth

Back 11

AZT (zidovudine)

Front 12

Drug used for African sleeping sickness

Back 12

Suramin

Front 13

Drug used in Chagas disease

Back 13

Nifurtimox

Front 14

Cephalosporins able to cross the BBB

Back 14

Cefuroxime (2nd) generation, Ceftazidime, Ceftriaxone

Front 15

Cephalosporins NOT able to cross the BBB

Back 15

Cefixime (3rd) generation

Front 16

Drug used for N. gonorrhea in females

Back 16

Ceftriaxone

Front 17

Cephalosporin causes kernicterus in neonates

Back 17

Ceftriaxone or cefuroxime

Front 18

SE of INH

Back 18

Peripheral neuritis and hepatitis

Front 19

Aminoglycoside that is least ototoxic

Back 19

Streptomycin

Front 20

Drug used in exoerythrocytic cycle of malaria

Back 20

Primaquine

Front 21

Oral antibiotic of choice for moderate inflammatory acne

Back 21

Minocycline

Front 22

Drug of choice for leprosy

Back 22

Dapsone, rifampin and clofazimine combination

Front 23

DOC for herpes and its MOA

Back 23

Acyclovir; incorporated into viral DNA and chain termination

Front 24

Anti-microbials that cause hemolysis in G6PD-deficient patients

Back 24

Sulfonamides

Front 25

MOA of erythromycin

Back 25

Inhibition of protein synthesis at the 50s subunit of ribosome

Front 26

Anti-biotic frequently used for chronic UTI prophylaxis

Back 26

sulfamethoxazole/ trimethoprim

Front 27

Lactam that can be used in PCN allergic patients

Back 27

Aztreonam

Front 28

SE of imipenem

Back 28

Seizures

Front 29

Anti-viral with a dose limiting toxicity of pancreatitis

Back 29

Didanosine

Front 30

Common side effect of hypnotic agents

Back 30

Sedation

Front 31

Occurs when sedative hypnotics are used chronically or at high doses

Back 31

Tolerance

Front 32

The most common type of drug interaction of sedative hypnotics with other depressant medications

Back 32

Additive CNS depression

Front 33

Benzodiazepines used to promote sleep

Back 33

Temazpam, trizolam, flurazepam

Front 34

Benzodiazepine used for anxiety

Back 34

Alprazolam

Front 35

Non-benzodiazepine used as an anxiolytic

Back 35

Buspirone

Front 36

Non-benzodiazepine used for sleep

Back 36

Zolpidem

Front 37

Major effect of benzodiazepines on sleep at high doses

Back 37

REM is decreased

Front 38

Neurologic SE of benzodiazepines

Back 38

Anterograde amnesia

Front 39

Reason benzos are used cautiously in pregnancy

Back 39

Ability to cross the placenta

Front 40

Main route of metabolism for benzodiazepines

Back 40

Hepatic

Front 41

Benzodiazepine that undergo extrahepatic conjugation (which are useful in older or hepatically impaired)

Back 41

Lorazepam, oxazepam, and temazepam

Front 42

MOA for benzodiazepines

Back 42

increase the FREQUENCY of GABA-mediated chloride ion channel opening

Front 43

Antidote to benzodiazepine overdose (antagonist that reverses the CNS effects)

Back 43

Flumazenil

Front 44

Benzodiazepine with useful relaxant effects in skeletal muscle spasticity of central origin

Back 44

Diazepam

Front 45

Benzodiazepine that has efficacy against absence seizures and in anxiety states, such as agoraphobia

Back 45

Clonazepam

Front 46

Benzodiazepines that are the most effective in the treatment of panic disorder

Back 46

Alprazolam and Clonazepam

Front 47

Benzodiazepine that is used for anesthesia

Back 47

Midazolam

Front 48

DOC for status epilepticus

Back 48

Diazepam

Front 49

Longer acting benzodiazepines used in the management of withdrawal states of alcohol and other drugs

Back 49

Chlordiazepoxide and Diazepam

Front 50

Agents having active metabolites, long half lives, and a high incidence of adverse effects

Back 50

Diazepam, Flurazepam, chlordiazepoxide, and clorazepate

Front 51

Barbiturates

Front 52

Barbiturates may precipitate this hematologic condition

Back 52

Acute intermittent porphyria

Front 53

Barbiturates decrease the effectiveness of many other drugs via this pharmacokinetics property

Back 53

Liver enzyme INDUCTION

Front 54

Barbiturates MOA

Back 54

Increase the DURATION of GABA-mediated chloride ion channels

Front 55

Barbiturate used for the induction of anesthesia

Back 55

Thiopental

Front 56

Site of action for zaleplon and zolpidem

Back 56

Benzodiazepine receptor BZ1 (although do not have a benzodiazepine ring structure)

Front 57

Good hypnotic activity with less CNS SE than most benzodiazepines

Back 57

Zolpidem, zaleplon

Front 58

Agent that is a partial agonist for the 5-HT1A receptor

Back 58

Buspirone

Front 59

Drug of choice for generalized anxiety disorder, NOT effective in acute anxiety

Back 59

Buspirone

Front 60

Agent that is metabolized to acetaldehyde by alcohol dehydrogenase and microsomal ethanol-oxidizing system (MEOS)

Back 60

Ethanol

Front 61

Agent with zero-order kinetics

Back 61

Ethanol

Front 62

Rate limiting step of alcohol metabolism

Back 62

Aldehyde dehydrogenase

Front 63

System that increases in activity with chronic ethanol exposure and may contribute to tolerance

Back 63

MEOS

Front 64

Enzyme that metabolizes acetaldehyde to acetate

Back 64

Aldehyde dehydrogenase

Front 65

Agents that inhibit acetaldehyde dehydrogenase

Back 65

Disulfiram, metronidazole, certain sulfonylureas and cephalosporins

Front 66

Agent that inhibits alcohol dyhydrogenase and its clinical use

Back 66

FOMEPIZOLE – used to prevent formation of toxic metabolites from methanol and ethylene glycol ingestion

Front 67

Agent used in the treatment of alcoholism, if alcohol is consumed concurrently, acetaldehyde builds up and results in nausea, headache, flushing, and hypotension

Back 67

Disulfiram

Front 68

The most common neurologic abnormality in chronic alcoholics

Back 68

Peripheral neuropathy (also excessive alcohol use is associated with HTN, anemia, and MI)

Front 69

Agent that is teratogen and causes a fetal syndrome

Back 69

Ethanol

Front 70

Agent that is the antidote for methanol overdose

Back 70

Ethanol, fomepizole

Front 71

Drug that inhibits alcohol dehydrogenase and is used in ethylene glycol exposure

Back 71

Fomepizole

Front 72

Most frequent route of metabolism

Back 72

Hepatic enzymes

Front 73

Mechanisms of action for Phenytoin, Carbamazepine, Lamotrigine

Back 73

Sodium channel blockade

Front 74

MOA for benzodiazepines and barbiturates

Back 74

GABA-related targets

Front 75

MOA for Ethosuximide

Back 75

Calcium channels

Front 76

MOA for Valproic acid at high doses

Back 76

Affect calcium, potassium, and sodium channels

Front 77

Drugs of choice for generalized tonic-clonic and partial seizures

Back 77

Valproic acid and Phenytoin

Front 78

DOC for febrile seizures

Back 78

Phenobarbital

Front 79

Drugs of choice for absence seizures

Back 79

Ethosuximide and valproic acid

Front 80

Drug of choice for myoclonic seizures

Back 80

Valproic acid

Front 81

Drugs of choice for status epilepticus

Back 81

IV diazepam for short term (acute) treatment; phenytoin for prolonged therapy

Front 82

Drugs that can be used for infantile spasms

Back 82

Corticosteroids

Front 83

Anti-seizure drugs used also for bipolar affective disorder (BAD)

Back 83

Valproic acid, carbamazepine, phenytoin and gabapentin

Front 84

Anti-seizure drugs used also for Trigeminal neuralgia

Back 84

Carbamazepine

Front 85

Anti-seizure drugs used also for pain of neuropathic orgin

Back 85

Gabapentin

Front 86

Anti-seizure agent that exhibits non-linear metabolism, highly protein bound, causes fetal hydantoin syndrome, and stimulates hepatic metabolism

Back 86

Phenytoin

Front 87

SE of phenytoin

Back 87

Gingival hyperplasia, nystagmus, diplopia and ataxia

Front 88

Anti-seizure agent that induces formation of liver drug-metabolism enzymes, is teratogen and can cause craniofacial anomalies and spina bifida

Back 88

Carbamazepine

Front 89

Agent that inhibits hepatic metabolism, is hepatotoxic and teratogen that can cause neural tube defects and gastrointestinal distress

Back 89

Valproic acid

Front 90

Laboratory value required to be monitored for patients on valproic acid

Back 90

Serum ammonia and LFT's

Front 91

SE for Lamotrigine

Back 91

Stevens-Johnson syndrome

Front 92

SE for Felbamate

Back 92

Aplastic anemia and acute hepatic failure

Front 93

Anti-seizure medication also used in the prevention of migraines

Back 93

Valproic acid

Front 94

Carbamazepine may cause

Back 94

Agranulocytosis

Front 95

Anti-seizure drugs used as alternative drugs for mood stabilization

Back 95

Carbamazepine, gabapentin, lamotrigine, and valproic acid

Front 96

MOA of general anesthetics

Back 96

Most are thought to act at GABA-A receptor - chloride channel

Front 97

Inhaled anesthetic with a low blood/gas partition coefficient

Back 97

Nitrous oxide

Front 98

Inversely related to potency of anesthetics

Back 98

Minimum alveolar anesthetic concentration (MAC)

Front 99

Inhaled anesthetics metabolized by liver enzymes which has a major role in the toxicity of these agents

Back 99

Halothane and methoxyflurane

Front 100

Most inhaled anesthetics SE

Back 100

Decrease arterial blood pressure