Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
13 Cards in this Set
- Front
- Back
Most widely used thyroid drug such as Synthroid and Levoxyl contain.....
|
L-thyroxine (T4)
|
|
T3 compound less widely used
|
Cytomel
|
|
Anti-thyroid drugs
|
Thioamides, Iodides, Radioactive Iodine, Ipodate
|
|
Thioamide drugs used in hyperthyroidism
|
Methimazole and Propylthiouracil (PTU)
|
|
Thioamide less likely to cross placenta, inhibits peripharal conversion of T4 to T3 in high doses, and should be used in extreme caution in pregnancy
|
Propylthiouracil (PTU)
|
|
MOA of PTU
|
Inhibits thyroid hormone synthesis by blocking iodination of the tyrosine residues of thyroglobulin
|
|
Can be effective for short term therapy of thyroid storm, but after several weeks of therapy causes an exacerbation of hyperthyroidism
|
Thyroxine
|
|
Dose may need to be increased during pregnancy or with OCs due to increased TBG in plasma
|
Thyroxine
|
|
Permanently cures thyrotoxicosis; patients will need thyroid replacement therapy thereafter; Contraindicated in pregnancy
|
Radioactive Iodine
|
|
Radio contrast media that inhibits the conversion of T4 to T3
|
Ipodate
|
|
Block cardiac adverse effects of thyrotoxicosis such as tachycardia, inhibits the conversion of T4 to T3
|
Beta-blockers such as propranolol
|
|
Vitamins containing iron should NOT be taken simultaneously with levothyroxine because...
|
Iron deiodinates thyroxine
|
|
Thyroxine dose may need to be increased in hypothyroid patient during pregnancy because...
|
Estrogens increase maternal TBG
|