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19 Cards in this Set
- Front
- Back
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Methotrexate
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MOA: S-phase antimetabolite; folic acid analog (inhibits DHF reductase)
tox: myelosuppression; fatty liver, mucositis reverse: leucovorin |
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5-FU
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MOA: S-phase antimetabolite; pyrimidine analog (5F-dUMP) which inhibits thymidylate synthase
tox: myelosupression, photosensitivity rescue: thymidine |
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6-MP
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MOA: blocks de novo purine synthesis; activated by HGPRTase
tox: BM, GI, liver; metabolized by xanthine oxidase (so watch when taking allopurinol) |
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ara-C (cytarabine)
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MOA: inhibits DNA polymerase
tox: leukopenia, thrombocytopenia, megaloblastic anemia |
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cyclophosphamide
Ifosfamide |
MOA: alkylating agent; x-link DNA at guanine N-7; activated by liver
tox: myelosuppression, hemorrhagic cystitis (prevent with mesna) |
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Nitrosureas (Carmustine, Lomustine, semustine, streptozocin)
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MOA: alkylate DNA; requires actiation; crosses BBB
tox: CNS toxicity (ataxia, dizziness) |
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Cisplatin
Carboplatin |
MOA: Cross-link DNA
tox: nephrotoxix, acoustic nerve damage |
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Busulfan
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MOA: alkylates DNA
use: BM ablation before stem cell tx tox: pulmonary fibrosis, hyperpigmentation |
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Doxorubicin (Adriamycin)
Daunorubicin |
MOA: generates free radicals; noncovalently intercalate in DNA
use: ABVD therapy for HL tox: cardiotoxicity, myelosuppression, alopecia; toxic extravasation |
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Dactinomycin
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MOA: DNA intercalators
use: childhood ttumors (Wilms, Ewings, rhabdomyosarcoma) tox: myelosuppression |
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Bleomycin
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MOA: free radical formation (breaks DNA strands)
use: ABVD for HL tox: pulmonary fibrosis, skin changes, minimal myelosuppression |
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Hydroxyurea
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MOA: inhibits ribonucleotide reductase (S-phase)
use: melanoma, SCD tox:BM suppression, GI upset |
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Etoposide
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MOA: G2 phase; inhibits topoisomerase II and increases DNA degradation
tox: myelosuppression, GI, alopecia |
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Prednisone
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MOA: apoptosis trigger
use: MOPP for HL tox: cushing-like symptoms (cataracts!) |
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Tamoxifen
Raloxiene |
MOA: ER antagonists
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Trastuzumab (Herceptin)
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MOA: monoclonal ab against HER-2 (erb-B2)
use: metastatic breast CA tox: cardiotoxicity |
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Imatinib (Gleevec)
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MOA: bcr-abl tyrosine kinase inhibitor
use: CML, GIST tox: fluid retention |
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Vincristine
Vinblastine |
MOA: M-phase alkaloids; bind to tubulin and block MT polymerization so can't form mitotic spindle
use: MOPP for HL tox: neurotoxic (peripheral neuropathy), paralytic ileus, BM suppression |
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Paclitaxel
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MOA: M phase (bind to tubulin and hyperstabilize polymerized MT so mitotic spindle can't break down); anaphase can't occur
tox: myelosuppression, hypersensitivity |
