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13 Cards in this Set
- Front
- Back
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NSAIDS Block What?
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-the arachidonic acid path.
-PG pathway (Prostigl._ -LT pathway (lipoxygenase) |
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How NSAID Block Fever?
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-inhib prostgl. E2 in the brain, controls temp.
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NSAIDS (Salicylates)
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Have antiplatelet activity
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NSAIDS (Acetic Acids), an example
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-Voltaren, diclofenac sodium
-Cataflam -Indocin -Clinoril -Tolectin |
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Carboxylic acids
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-ASA (Acetylated)
-Toradol (Nonacetylated) |
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Propionic Acids
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These are the "profins"
-motrin, Nalfon, ansaid, aleve, daypro |
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COX-2 inhibitors>
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Celecoxib (Celebrex)
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Asprin has great effects...
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potent effect on platelet aggregation and thermal reg, analgesic, antithrombotic
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NSAID Adverse effects...
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-GI, Renal (decreased creatinine clearance,renal failure)
-Cardiovascular, noncard. pulmonary edema |
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Salicylate Toxicity occurs..
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-serum levels <40 to 60 mg/dl
-metabolic acidosis and respiratory alkalosis |
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NSAIDS, interactions
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-Anticoagulants
-asprin -Corticosteroids, ulcerogenic drugs -Protein bound drugs |
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Antirheumatoid drugs are
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-AKA disease-modifying antirheumatic drugs (DMARDs),
-More toxic than NSAIDS -3-6 months to take effect. |
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Therapeutic effects of Salicylates are seen in how many weeks?
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3-4
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