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21 Cards in this Set

  • Front
  • Back
acute inflammatory response
histamine, PGs, 5HT, LTs
chronic inflammatory response
TNF, interleukin, interferon
indomethacin
non-salicylic NSAID, COX1 & COX2 inhibitor (closes patent ductus arteriosis)
acetyl salicylic acid
four A's
in addition to cox inhibitor also inhibits kallikrein (decrease bradykinin a vasodialator), not a good anti-inflammatory, good for TIA, coronary thrombosis, by pass surgery, and colon cancer,
non-acetylated salicylic acid
3 A's (low analgesic) minus anti-coagulant, does not inhibit PG synthesis, effects hypertension drugs
non-salicylic NSAIDS (COX 1 & 2)
4 A's
shorter halflife than ASA, effects hypertension drugs, less GI irritation but still some, accumulates in synovial fluid, good anti-inflammatory
non-salicylic NSAIDS (COX 2)
3 A's minus anti-coag
COX2 is only expressed during inflammation, great anti-inflammatory, reduced GI effects but still some, effects hypertension drugs, asthma still a concern
acetominophen
COX 1 & 2 inhibitor
2 A's minus anti-inflammatory and anti-coagulant, no gastric irritation, less asthma risk, Reyes syndrome a problem, COX inhibition in CNS not PNS
ASA
irreversibly binds COX 1 & 2,
ASA
irreversible COX 1 & 2
ibuprofen
non salicylic NSAIDS, COX 1 & 2
diclofenac
non salicylic NSAIDS, COX 1 & 2
indomethacin
non salicylic NSAIDS, COX 1 & 2
naproxen
non salicylic NSAIDS, COX 1 & 2
etodolac
non salicylic NSAIDS, COX 1 & 2
ketoprofen
non salicylic NSAIDS, COX 1 & 2
sulindac
non salicylic NSAIDS, COX 1 & 2
celecoxib
celebrex, non salicylic NSAID, COX 2 only
no anti-coag
still some GI effects
still a kidney effect and reduces effectiveness of anti-hypertensives
rofecoxib
vioxx, non salicylic NSAID, COX 2 only
most potent of the COX 2's
no anti coag
still some GI effects
still a kidney effect and reduces effectiveness of anti-hypertensives
valdecoxib
bextra, non salicylic NSAID, COX 2 only
no anti-coag
still some GI effects
still a kidney effect and reduces effectiveness of anti-hypertensives
mucomyst
used for acetaminophen overdose, maintains glutathione stores by binding to the reactive metabolite as it is produced