Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
21 Cards in this Set
- Front
- Back
|
acute inflammatory response
|
histamine, PGs, 5HT, LTs
|
|
|
chronic inflammatory response
|
TNF, interleukin, interferon
|
|
|
indomethacin
|
non-salicylic NSAID, COX1 & COX2 inhibitor (closes patent ductus arteriosis)
|
|
|
acetyl salicylic acid
|
four A's
in addition to cox inhibitor also inhibits kallikrein (decrease bradykinin a vasodialator), not a good anti-inflammatory, good for TIA, coronary thrombosis, by pass surgery, and colon cancer, |
|
|
non-acetylated salicylic acid
|
3 A's (low analgesic) minus anti-coagulant, does not inhibit PG synthesis, effects hypertension drugs
|
|
|
non-salicylic NSAIDS (COX 1 & 2)
|
4 A's
shorter halflife than ASA, effects hypertension drugs, less GI irritation but still some, accumulates in synovial fluid, good anti-inflammatory |
|
|
non-salicylic NSAIDS (COX 2)
|
3 A's minus anti-coag
COX2 is only expressed during inflammation, great anti-inflammatory, reduced GI effects but still some, effects hypertension drugs, asthma still a concern |
|
|
acetominophen
|
COX 1 & 2 inhibitor
2 A's minus anti-inflammatory and anti-coagulant, no gastric irritation, less asthma risk, Reyes syndrome a problem, COX inhibition in CNS not PNS |
|
|
ASA
|
irreversibly binds COX 1 & 2,
|
|
|
ASA
|
irreversible COX 1 & 2
|
|
|
ibuprofen
|
non salicylic NSAIDS, COX 1 & 2
|
|
|
diclofenac
|
non salicylic NSAIDS, COX 1 & 2
|
|
|
indomethacin
|
non salicylic NSAIDS, COX 1 & 2
|
|
|
naproxen
|
non salicylic NSAIDS, COX 1 & 2
|
|
|
etodolac
|
non salicylic NSAIDS, COX 1 & 2
|
|
|
ketoprofen
|
non salicylic NSAIDS, COX 1 & 2
|
|
|
sulindac
|
non salicylic NSAIDS, COX 1 & 2
|
|
|
celecoxib
|
celebrex, non salicylic NSAID, COX 2 only
no anti-coag still some GI effects still a kidney effect and reduces effectiveness of anti-hypertensives |
|
|
rofecoxib
|
vioxx, non salicylic NSAID, COX 2 only
most potent of the COX 2's no anti coag still some GI effects still a kidney effect and reduces effectiveness of anti-hypertensives |
|
|
valdecoxib
|
bextra, non salicylic NSAID, COX 2 only
no anti-coag still some GI effects still a kidney effect and reduces effectiveness of anti-hypertensives |
|
|
mucomyst
|
used for acetaminophen overdose, maintains glutathione stores by binding to the reactive metabolite as it is produced
|
