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45 Cards in this Set
- Front
- Back
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Increases the frequency of GABA channel opening?
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Benzodiazepines
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Increases the duration of GABA opening?
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Barbituates
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#1 antipsychotic
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respiridone (atypical)
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Difference between typical and atypical antipsychotics?
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Both work by decreasing dopamine but typicals have many extra-pyramidal side effects.
Aypicals are prominantly D2R antagonists. |
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Tx for situational anxiety?
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Beta-blockers, SSRI's
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Typical anti-psychotics?
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Butyrophenone
Phenothiazines Thioxanthines |
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Atypical antipsychotics?
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Clozapine, Respiridone
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Treatment of OCD?
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SSRI's (#1)
TCA's SNRI's (venlafaxine) |
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1st choice for bipolar?
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Lithium
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2nd choice for bipolar?
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Sodium Valproate (Valproic acid)
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3rd choice for bipolar?
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Carbamazepine
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#1 for generalized anxiety?
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benzodiazepines
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SSRI's
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Citalopam
Fluoxitene Fluvoxamine Paroxitene Sertraline |
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Tx for parkinson's?
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L-dopa + carbidopa = dopamine precursor (crosses BBB) + peripheral dopa decarboxylase inhibitor
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2nd line Tx for parkinsons? (if L-dopa/carbidopa doesn't work)
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Bromocriptine, Pergolide, Pramipexole, Ropinirole
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What is the role of selegeline in Parkinson's treatment?
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MAO-B inhibitor that decreases breakdown of dopamine increasing it's effect.
decreases on/off phenomena of L-dopa therapy |
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MAO inhibitors?
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Phenelzine (MAO A and B inhibitor)
Moclobemide (MAO A) selegeline (MAO B) |
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TCA's?
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amitriptiline
imipramine chlorimipramine desipramine |
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SSRI's?
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fluoxetine
sertraline paroxitene |
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Tx of grand mal or partial seizures?
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phenobarbital
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1st line for partial seizures?
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Carbamazipine and Phenytoin
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2nd line for partial seizures?
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Lamotrigine
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1st choice for generalized seizures?
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Absense: Valproate/Ethosuximide
Myoclonic: Valproate (#2 clonazepam) Atonic: Valproate Tonic-Clonic: Valproate |
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Tx strategy for status epilepticus?
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First: Diazepam or Lorazepam until control is established.
Then: Phenytoin, fosphenytoin (IM), and Phenobarbital |
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Theory behind tx of epilepsy?
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prolong GABA (benzo's, barb's, topiramate)
inhibit glutamate |
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Inhibits GABA-transaminase (inhibits GABA catabolism)
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Vigabitrin
Valproate |
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Inhibits GABA reuptake
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Gabapentin
Tiagabine |
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Barbituates from longest to shortest duration of action
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phenobarbital>pentobarbital>secobarbital>thiopental
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Benzodiazepines from longest to shortest duration of action?
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Flurazepam>temazepam>triazolam
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#1 hypnotic? #1 barb hypnotic? #1 bzd hypnotic?
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zolipidem (no tolerance, dependency, non-bzd that binds to receptor, SLEEP AID (ambien), weird side effects=dog barking)
secobarbital (mod acting barb) tiazolam (short acting bzd) |
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Most common general anesthetic for induction?
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nitrous oxide
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Most common general anesthetic for maintanence?
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fluranes
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Unilateral, throbbing headache with photophobia
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Migraine, tx = sumatriptan
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Episodic, time-specific headaches
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Cluster, tx = sumatriptan
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headache associated pain accompanied by discharge
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sinus headache, tx = treat the infection...amoxicillin
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"My scalp hurts"
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tension headache, tx = amitryptiline, alprazolam, or buspirone
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#1 prophylactic for migraines
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propanolol
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#1 prophylactic for cluster headache?
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verapamil
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Endogenous opioids?
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Enkephalins (mu/delta receptor)
endorphins (mu receptor) dynorphins endomorphin |
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Signs of opioid toxicity (especially morphine)
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respiratory depression, miosis, constipation, rash, addiction, tolerance, suppresed cough reflex
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10x more potent than morphine? 100x?
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hydromorphone
fentanyl |
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#1 narcotic, used as anti-tussive
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codiene
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best PO bioavailablity of opioid?
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oxycodone
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Opioid antagonists?
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Naloxone, Naltrexone
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Mixed opioid agonists/antagonists?
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Pentazocine (mu antagonist, k agonist)
Butorphanole (mu antagonist, k agonist) Buprenorphine |
