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42 Cards in this Set
- Front
- Back
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An antiseizure med with two active metabolites
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Primidone (antiseizure med) with 2 active metabolites: Phenobarbital (major) & PEMA (minor)
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Antimuscarinics used in Parkinsons
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Benztropine & trihexyphenidyl (anti-muscarinics) used in Parkinsons
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Anxiolytic with tachycardia & dose-dependent miosis
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Buspirone, partial 5HT-1A agonist (very weak anti-DA)
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Baclofen MOA
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Baclofen is a spasmolytic acting by activating GABA-B receptors
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Bupropion MOA & S/E
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Bupropion inhibits NE & DA reuptake; S/E is lower seizure threshold
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Carbamazepine S/E
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Aplastic anemia, SJS with HLA B1502, SIADH, & induces P450
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Carbidopa MOA
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Inhibits peripheral AAD (blocks L-dopa -> DA in periphery)
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DOC for OCD
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SSRI like fluoroxetine or sertraline; or Clomipramine (TCA)
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DOC for emesis caused by incr intracranial pressure
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Mannitol or Dexamethasone
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DOC for post-coital contraception
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Mifepristone (RU486, anti-progestin) & Misoprisol (PGE1 analog, cervical dilator) used for abortions
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DOC for trigeminal neuralgia
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Carbamazepine (Na channel blocker; antiseizure)
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Disulfiram MOA
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inhibits Aldehyde Dehydrogenase
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Ethosuximide MOA
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Inhibits T-type Ca Channels (antiseizure used for Absence Seizures)
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Ethosuximide S/E
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Stevens Johnson Syndrome
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How do you reverse neuromuscular blockers?
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Neostigmine, Physostigmine & Edrophonium can reverse neuromuscular blockers
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List 3 MAO-Is
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Phelenzine, Tranylcypromine, Isocarboxazid
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Long-acting amide, IV can ppt arrhythmias & hypotension
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Bupivacaine (long-acting amide) can ppt arrhythmias & hypotension if given IV
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MOA of Ketamine
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Ketamine (dissociative anesthetic) blocks NMDA & HCN1 receptors
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MOA of Primidone
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Primidone (antiseizure med) with 2 active metabolites: Phenobarbital (major) & PEMA (minor)
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Memantine MOA & Indication
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Glutamate NMDA blocker, used in Alzheimers
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Name 4 AChE-I used in Alzheimer's Dz
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Alzheimer's Dz AChE-Is: Donepezil, Galantamine, Rivistagmine (maybe Tacrine?)
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Post-op ileus or atony of bladder DOC & 2nd line
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Neostigmine (reversible AChE-I), 2nd line Bethanechol (M3-selective agonist)
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Rapidly acting benzodiazepine used for date-rape
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Flunitrazepam is rapidly acting benzo, with sedation & amnesia, used as date-rape drug
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Restless leg syndrome DOC
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Ropinirole (non-ergot dopamine agonist)... (remember Ach inverse to DA) [roe-PIN-uh-ROLE]
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Spasmolytic GABA-B agonist
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Baclofen is a spasmolytic acting by activating GABA-B receptors
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Sprain/strains acute local muscle spasms DOC
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Local muscle spasm use centrally-acting relaxants: Cyclobenzaprine (TCA deriv, 18h t1/2)/Metaxalone,
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TCA used for enuresis
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Imipramine
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Tx of Bipolar Depression
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Bipolar Depression Tx: Lamotrigene, Lithium, atypical antipsychotics (esp Quietapine > Olanzapine)
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What is the TCA stem?
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TCA stem is -triptyline or -ipramine, except for Doxepin
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Which SSRI is not indicated for depression?
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Fluvoxamine is the only SSRI not indicated for depression, it is only approved for OCD
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Which SSRI should be used in caution with caffeine?
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Fluvoxamine (SSRI) inhibits CYP1A2, should be used in caution with caffeine
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Which TCA is not indicated for depression?
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Clomipramine is only TCA not indicated for depression, only approved for OCD
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Why are Antimuscarinics used in Parkinsons?
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DA & ACh are normally balanced in CNS, in Parkinsons Decr DA & Incr ACh->Tremor. Antimuscarinics (Benztropine & trihexyphenidyl) ->Decr ACh activity in Parkinsons Dz
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Ziprasidone MOA & S/E
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Ziprasidone (atypical antipsychotic) blocks DA2r & 5HT2r, S/E is long QT syndrome
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DOC for OCD
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SSRI like fluoroxetine or sertraline; or Clomipramine (TCA)
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Disulfiram MOA
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inhibits Aldehyde Dehydrogenase
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TCA used for enuresis
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Imipramine
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MC used Typical Antipsychotics
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Chlorpromazine (Thorazine), Thioridazine (Mellaril), Fluphenazine (Prolaxin) [Haloperidol (Haldol) MC used for sedation]
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Tourette's Tx
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Atripcals (esp Risperidone), Clonidine/Guanfacine, SSRIs
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Which atypical antipsychotics have IM form?
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Ziprasidone & Olanzapine
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TCA OD Tx
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Sodium bicarb & benzos
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Chlordiazepoxide MOA
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GABA agonist, a BZD, brand name Librium
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