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16 Cards in this Set
- Front
- Back
what are the inhalational anesthetics?
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Sevoflurane & Desflurane
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Desflurane
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MOA:
*inhalational anesthetic *decr EPSP: drugs enter lipid-protein matrix of neuron membranes & REVERSIBLY disrupts Na, K, Ca channel fxn directly or indirectly *incr IPSP: -incr GABA-A activated Cl flux -low [drug] facilitates GABA actioan to incr GABA-A activated Cl flux -high [drug] DIRECTLY activates GABA-A to incr Cl flux S/E of Desflurane: -transient incr HR/BP -airway irritation (cough) when used alone==>pre-Tx with narcotics to reduce S/E -CO toxicity (carboxy hemoglobin) S/E of Sevoflurane: decr contractility and CO at 1 MAC conc |
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inhalational analgesic
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NO
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NO
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PE:
*d/t limited solubility in blood, NO has rapid onset & offset *potential inhalational analgesic ==>thus, no sig effects on CV, resp, hepatic, renal, or autonomic NS Tx: lowers [inhalational anesthetic] required to produce same level of anesthesia S/E: *hypoxia *increased pressure in closed compartments==>incr gastric volume/pressure (don't use for abdominal surgery) |
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what drug not to use for abdominal surgery?
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NO (b/c incr gastric volunme/pressure)
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what anesthetic is causes less injection site irritation?
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midazolam ("--lam"==>thus, BZ)
(more water soluble==>decr injection site irritation) |
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what anesthetic has rapid onset of sleep and recovery?
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propofol & etomidate
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what anesthetic causes injection site burning?
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propofol
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propofol
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MOA: incr inhibitory synaptic transmission via facilitation of GABA-A receptor
PE: dose-dependent depression of CNS & respiration (possible apnea)--EXAM -anti-emetic (reduce N/V) Tx: rapid onset of sleep & recovery w/less hangover S/E: injection site burning |
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what drug causes myoclonus (spontaneous involuntary muscle mvmt & tremor)
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etomidate
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etomidate
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MOA: incr inhibitory synaptic transmission by interacting w/GABA-A
Tx: rapid onset of sleep & recovery S/E: myoclonus (excitatory phenomenon including spontaneous involuntary muscle mvmt & tremor) *marked adenocortical suppression for 4 days after d/c |
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what drug causes marked adenocortical suppression for 4 days after d/c
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etomidate
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what causes dissociative anesthesia
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dissasociative anesthesia=cataleptic trance-like state (person appears awake w/eyes open)
caused by ketamine |
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Ketamine
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MOA:
*non-comp antagonist of NMDA glutamate receptor in s.c. *decr synaptic transmission by reducing synaptic Ca channel conduction PE: incr BP, HR, cardiac index (opp of other inhalational anesthetics) Tx: *profound analegesia--EXAM *disassociate anesthesia-EXAM *used in kids b/c no bad dreams & hallucination S/E: *bad dreams & hallucinations in adults *incr intracranial pressure |
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what drug causes bad dreams & hallucinations
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ketamine (only in adults)
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what drug causes profound analgesia (even at sub-anesthetic concentrations)
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ketamine
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