Study your flashcards anywhere!

Download the official Cram app for free >

  • Shuffle
    Toggle On
    Toggle Off
  • Alphabetize
    Toggle On
    Toggle Off
  • Front First
    Toggle On
    Toggle Off
  • Both Sides
    Toggle On
    Toggle Off
  • Read
    Toggle On
    Toggle Off
Reading...
Front

How to study your flashcards.

Right/Left arrow keys: Navigate between flashcards.right arrow keyleft arrow key

Up/Down arrow keys: Flip the card between the front and back.down keyup key

H key: Show hint (3rd side).h key

A key: Read text to speech.a key

image

Play button

image

Play button

image

Progress

1/16

Click to flip

16 Cards in this Set

  • Front
  • Back
what are the inhalational anesthetics?
Sevoflurane & Desflurane
Desflurane
MOA:
*inhalational anesthetic
*decr EPSP: drugs enter lipid-protein matrix of neuron membranes & REVERSIBLY disrupts Na, K, Ca channel fxn directly or indirectly
*incr IPSP:
-incr GABA-A activated Cl flux
-low [drug] facilitates GABA actioan to incr GABA-A activated Cl flux
-high [drug] DIRECTLY activates GABA-A to incr Cl flux

S/E of Desflurane:
-transient incr HR/BP
-airway irritation (cough) when used alone==>pre-Tx with narcotics to reduce S/E
-CO toxicity (carboxy hemoglobin)
S/E of Sevoflurane: decr contractility and CO at 1 MAC conc
inhalational analgesic
NO
NO
PE:
*d/t limited solubility in blood, NO has rapid onset & offset
*potential inhalational analgesic
==>thus, no sig effects on CV, resp, hepatic, renal, or autonomic NS

Tx: lowers [inhalational anesthetic] required to produce same level of anesthesia

S/E:
*hypoxia
*increased pressure in closed compartments==>incr gastric volume/pressure (don't use for abdominal surgery)
what drug not to use for abdominal surgery?
NO (b/c incr gastric volunme/pressure)
what anesthetic is causes less injection site irritation?
midazolam ("--lam"==>thus, BZ)
(more water soluble==>decr injection site irritation)
what anesthetic has rapid onset of sleep and recovery?
propofol & etomidate
what anesthetic causes injection site burning?
propofol
propofol
MOA: incr inhibitory synaptic transmission via facilitation of GABA-A receptor
PE: dose-dependent depression of CNS & respiration (possible apnea)--EXAM
-anti-emetic (reduce N/V)

Tx: rapid onset of sleep & recovery w/less hangover

S/E: injection site burning
what drug causes myoclonus (spontaneous involuntary muscle mvmt & tremor)
etomidate
etomidate
MOA: incr inhibitory synaptic transmission by interacting w/GABA-A
Tx: rapid onset of sleep & recovery
S/E: myoclonus (excitatory phenomenon including spontaneous involuntary muscle mvmt & tremor)
*marked adenocortical suppression for 4 days after d/c
what drug causes marked adenocortical suppression for 4 days after d/c
etomidate
what causes dissociative anesthesia
dissasociative anesthesia=cataleptic trance-like state (person appears awake w/eyes open)

caused by ketamine
Ketamine
MOA:
*non-comp antagonist of NMDA glutamate receptor in s.c.
*decr synaptic transmission by reducing synaptic Ca channel conduction

PE: incr BP, HR, cardiac index (opp of other inhalational anesthetics)

Tx:
*profound analegesia--EXAM
*disassociate anesthesia-EXAM
*used in kids b/c no bad dreams & hallucination

S/E:
*bad dreams & hallucinations in adults
*incr intracranial pressure
what drug causes bad dreams & hallucinations
ketamine (only in adults)
what drug causes profound analgesia (even at sub-anesthetic concentrations)
ketamine