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56 Cards in this Set

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anti-depressant that causes Dry mouth, urinary retention, blurred vision, constipation, memory impairment, sexual dysfunction, tachycardia
TCA
anti-depressant that causes Sedation & weight gain
TCA
anti-depressant that causes Orthostatic hypotension, sexual dysfunction
TCA
a1-adrenergic blockade causes what?
Orthostatic hypotension, sexual dysfunction
H1 blockade causes what?
sedation, wt gain
muscarinic blockade causes what?
tachycardia, dry mouth, urinary retention, constipation, sex dysfxn, memory impairment
what anti-depressant can cause tremor of extremities or ataxia
TCA
what anti-depressant can initiate of manic episodes in bipolar pts
TCA
what anti-depressant can lower seizure threshold & inc risk of tonic clonic seizures
TCA
S/E of TCA
1. anti-muscarinic: dry mouth, tachycardia, sex dysfxn, urinary retention, constipation, memory impairment
2. anti-H1: sedation, wt gain
3. anti-a1 adrenergic: orthostatic hypotention, sex dysfxn
4. CNS:
-tremor of extremities or ataxia
-manic episodes in bipolar pt
-tonic clonic seizures (lower seizure threshold)
what are the TCA's?
Desipramine & Imipramine (selectively block NE reuptake)

-mirtazopine is related (non-selectively blocks both NE and 5-HT reuptake)
MOA of mirtazapine?
*a2-adrenoceptor Blocker==> release of NE & facilitates noradrenergic transmission
what are the SSRI's?
Citalopram
Fluox
Fluvox
Parox
Sertraline
Venlafaxine
S/E of SSRI's
-NV, sex dysfxn
-anxiety
-wt gain
-NO anticholingeric S/E or effects on heart's conduction system
what drug can you give along with SSRI to relieve sex dysfxn?
bupropion
what drug has greater tendency to produce seizures than other other AD, especially in pp with eating D/O?
bupropion
what are the MAOI's?
Phenelzine
Tranylcypromine
MOA of venlafaxine?
*At low doses (~75 mg) = SSRI
*At high doses (>300 mg) = non-selectively blocks reuptake of 5-HT & NE (like Imi)
S/E of MAOI's?
ingesting foods or drugs containing sympathomimetic amines (eg Tyramine) can induce HYPERTENSIVE CRISIS ("cheese rxn")
if pt taking decongestant (i.e. Sudafed), what drug should they not take?
MAOI
MOA of Desipramine
selectively blocks reuptake of NE
MOA of Imipramine
non-selectively blocks reptake of both 5-HT and NE
names of Benzodiazepines?
anything that ends in "pam" or "lam"

(Note: citalopram (SSRI) looks like it might be a BZ, but it's "pRam," not "pam")
MOA of BZ?
GABA hyperpolarization via Cl channels
PE of BZ?
Anti-anxiety:
-sedative hypnotic
-muscle relaxant
DOC for anxiety in old ppl?
Why?
Oxazepam
-b/c metabolized by conjugation to glucoronic acid (does not decrease with aging)--vs oxidative rxn
what BZ has shortest duration of action
triazolam
Tx Panic Disorder
alprazolam & clonazepam
(makes sense that you use BZ's ("--lam", "--pam") to Tx panic d/o

mneum: "AL Capone (sounds like ALprazolam & CLONazepam) has Panic d/o"
which BZ are anxiolytic
-Alprazolam
-Colanzepam
-Diazepam
-Oxazapam
which BZ are hypnotic
-Flurazepam
-Triazolam
S/E of BZ
1. when combined with alcohol, BZ can increase suicide potential (alcohol potentiates effects of all BZ's except the "Z's")

2. withdrawal rxn if taking longer than 8 months
optimal Tx for anxiety?
-start with BZ (b/c works fast) + SSRI, but then remove BZ after 1 month (b/c withdrawal rxn occurs if take for 8 months)
DOC for OCD?
PE?
MOA?
clomipramine
PE: increase 5-HT in brain (EXAM)

MOA: Clomipramine is a Cl- derivative of Imi, so blocks reuptake of both NE and 5-HT (like Imi), but is more potent at blocking 5-HT reuptake, which is more effective in Tx OCD
Tx Social Anxiety D/O?
SSRI's
(Citalopram
Fluox
Fluvox
Parox
Sertraline
Venlafaxine)
what Tx anxiety has minimal withdrawal potential and slower onset than BZ?
Buspirone
what anti-anxiety drug hyperpolarizes via K-channels?
Buspirone (EXAM)
what anti-anxiety drug directly activates 5-HT1a receptor?
buspirone
Tx Post-Traumatic Stress Disorder?
Paroxetine & Sertraline (SSRIs)

(mneum: Tx PTSD with P & S)
MOA of Zolpidem, Zaleplon, EsZopiclone?
BZ agonists; BZ1-R > BZ2-R
hypnotics (cause sleep)?
get your Z's:
-Zolpidem
-Zaleplon
-EsZopiclone
S/E of
Zolpidem
Zaleplon
EsZopiclone
sleepwalking and amnesia
how Tx BZ overdose
MOA?
Flumazenil
MOA: acts at BZ-receptor to prevent binding of BZ
Amphetamine
MOA:
*indirect-acting sympathomimetic amine
*release NE & DA from intraneuronal stores & blocks their reuptake
==>prlonged action at synapse
*Schedule 2

PE:
*mood elevation
*incr wakefulness
*anorexiant

S/E:
*teeth break off (meth mouth)

Acute toxicity:
*CNS stimulation
*Paranoid psychosis
*Sympathomimetic amine, thus incr SNS==>
-Hypertensive crisis
-Tachycardia/Arrhythmias
-Hyperthermia, convulsions, coma

Chronic toxicity:
-Amphetamine psychosis (halluc, delusions of persecution & omnipotence)
DOC of ADHD
MOA?
D-amphetamine
Methylaphenidate (Ritalin)

MOA: release NE & DA from intraneuronal stores & blocks their reuptake (same MOA as amphetamines)
Concerta?
Concerta=
slow release Methylphenidate
==>suppresses appetite
Phentermine
MOA: same as Amphetamine
Tx: anorexiant (ST use)
S/E: lower abuse potential than Amphetamines
Sibutramine
MOA:
*blocks neuronal uptake of NE, 5-HT, & DA
*metabolized to active metabolites via CYP3A4
*Schedule 4 (so not that addictive)

Tx: anorexiant

S/E:
*NO CNS depression, abuse potential, drug dependence, or valvular pathology

*speed up metab to lose wt:
==>tachycardia, PVC's, HTN, HA, dry mouth, insomnia, constipation

mneum: "Si, your BUTt is too big...you should take an anorexiant"
what drug do you not give with MAOi's?
-Atomoxetine (Tx: ADHD)
-Sudafed
Atomoxetine
Tx: ADHD

mneum: The only way you can get the attention of a kid with ADHD is to drop an ATOM bomb on him.


MOA: selective NE uptake inhibitor

S/E: don't give with MAOi's

mneum: don't give ATOM bomb with MAOi because China (MAO) and Japan (atom bomb) are not on good terms.
DOC for narcolepsy
modafinil

(mneum: Morpheus is the god of sleep, so Modafinil is the god of no sleep)
DOC for Neonatal Apnea Syndrome
Theophylline
TCA's
-desiprimine
-imiprimine
-mirtazipine
SSRI's
citalopram
fluoxetine
fluvoxamine
paroxetine ("par" comes after the "pair" of flus)
sertraline (~"serotonin")
venlafaxine
MAOi's
tranylcyclomine
phenelzine

"Transsexuals take phen-phen to inhibit MAO"
typical antipsychotics
haloperidol
chlorpromazine
atypical antipsychotics
Clozapine
RisperIDONE
Olanzepine
Quietapine
Aripiprazole
ZiprasIDONE

(“CROQAZ” sounds like croquet—imagine Winona Ryder from Heathers taking atypical antipsychotics b/c she killed her classmates.)