Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
9 Cards in this Set
- Front
- Back
|
phenytoin
a/e - megaloblastic anemia, SLE-like syndrome, induction of cytochrome P450 enzymes, hirsutism |
MOA - incr Na+ channel inactivation
1st line in tonic-clonic seizures 1st line in prophylaxis of status epilepticus also used for tx of partial seizures |
|
|
carbamazepine
a/e - sedation, tolerance, dependence |
MOA - incr Na+ channel inactivation
1st line for trigeminal neuralgia 1st line for tonic-clonic also used for tx of partial seizures |
|
|
lamotrigine
a/e - steven johnson syndrome (prodrome of malaise, fever followed by rapid onset of erythematous macules) |
MOA - blocks voltage gated Na+ channels
tx of partial, tonic-clonic |
|
|
gabapentin
a/e - sedation, ataxia |
MOA - incr GABA release
tx of partial, tonic-clonic, peripheral neuropath |
|
|
topiramate
a/e - sedation, mental dulling, kidney stones, wt loss |
MOA - blocks Na+ channels, incr GABA action
tx of partial, tonic-clonic seizures |
|
|
phenobarbital
a/e - sedation, tolerance, dependence, induction of cytochrome p450 enzymes |
MOA - incr GABA action
1st line in PREGNANT WOMEN, CHILDREN |
|
|
valproic acid
a/e - GI distress, neural tube defects, C/I in pregnancy |
MOA - incr Na+ channel inactivation, incr GABA conc
1st line in tonic-clonic others- tonic-clonic, ABSENCE, partial also used for MYOCLONIC seizures |
|
|
ethosuximide
a/e - EFGH (ethosuximide - fever, GI distress, headache) |
MOA = blocks thalamic t-type Ca2+ channels
1st line for ABSENCE |
|
|
benzodiazepines (diazepam, lorazepam)
a/e - sedation, tolerance, dependence |
MOA - incr GABA action
1st line for acute STATUS EPILEPTICUS others - seizures of ecclampsia (1st line is magnesium sulfate) |
