Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
22 Cards in this Set
- Front
- Back
|
Infliximab
|
monoclonal AB, anti-TNF alpha, inhibiting pro-inflammatory events, made of human/mouse chimera.
Tx for RA and Crohn's AE are serum sickness, hepatosplenic lymphona when coadmin with azathrioprine, risk of opportunistic infections |
|
|
Adalimumab
|
monoclonal Ab, anti-TNF alpha, inhibiting pro-inflammatory events, completely humanized
Tx for RA, Crohns, ankolosing spondylitis AE are FDA Black Box warning for Tb and opportunistic infections, exacerbates CHF, can have lupus-like syndromes |
|
|
Etanercept
|
a receptor-like molecule that binds TNF-alpha, inhibiting pro-inflammatory events
Tx for RA, immunosuppresion, adjuct with methotrexate AE are auto-Ab formation, hypersensitivity rxns Contra in sepis, doc hypersensitivities, MS, and concurrent with live vaccines |
|
|
Anakinra
|
binds the IL-1 receptor, blocking action.
Tx for RA AE are headaches, infections, decreased WBC, Ab against drug |
|
|
Penicillamine
|
unknown MOA
Tx for RA and Wilson's disease (it chelates Cu) AE can lead to fatal bone marrow suppresion, is teratogenic, hypersens rxn |
|
|
Hydoxychloroquine
|
suppresses T cell response, decreases leukocyte chemotaxis, stabilizes lysosomal membrane
Tx for RA and SLE AE mild with dermatitis, GI irritation, nightmares, and reversible corneal opacity AE BAD can include irreversible retinal degen with night blindness, blurred vision, light flashes, and photophobia |
|
|
Sulphasalazine
|
metabolized to mesalamine in gut, decreasing PG synth.
Tx for ulcerative colitis and RA |
|
|
Pancuronium
|
short acting muscle relax
non-depolarizing NMJ comp inhibitor onset in 1-3m, duration 60-100min, very potent has histamine release, careful with cardiac disease surgical relaxation and control of ventilation |
|
|
Rocuronium
|
short acting muscle relax
non-depolarizing NMJ comp inhibitor onset in 1-2m, duration 30-60min no histamine release surgical relaxation and control of ventilation |
|
|
Mivacurium
|
acting muscle relax
non-depolarizing NMJ comp inhibitor onset in 1.5-3m, duration 10-15min has profoud histamine release, careful with cardiac disease surgical relaxation and control of ventilation |
|
|
Atacurium
|
acting muscle relax
non-depolarizing NMJ comp inhibitor onset in 2-3m, duration 30min forms laudanosine leading to seizures, careful with cardiac disease surgical relaxation and control of ventilation |
|
|
Vecuronium
|
acting muscle relax
non-depolarizing NMJ comp inhibitor onset in 3-5min, duration 30min, very potent surgical relaxation and control of ventilation |
|
|
Tubocurarine
|
acting muscle relax
non-depolarizing NMJ comp inhibitor onset in 3-5m, duration 30-60min no longer used due to side effects surgical relaxation and control of ventilation |
|
|
Cisatracurium
|
acting muscle relax
non-depolarizing NMJ comp inhibitor onset in 3-5m, duration 30-60min surgical relaxation and control of ventilation |
|
|
Succinyl choline
|
the only depolarizing NMJ blocker,
vasciculations preceed paralysis onset in 0.5-1min, duration 5-10min tracheal intubation and Tx of convulsions AE are hyperkalemia, increased intraoccular pressure, malignamnt hyperthermia, and cardiac arrythmia with halothane anestesia Contra in burn victims |
|
|
Diazepam/lorazepam
"benzodiazepines" |
central acting, amplifies GABA in CNS, leading to increase in Cl- and hyperpolarization.
Tx muscle spasms of any origin |
|
|
Baclofen
|
central acting derivative of GABA
Tx severe spasticity in MS or spinal trauma pts |
|
|
Tizanidine
|
alpha 2 agonist that reduces NT release in CNS
tx for muscle cramping, tightness, and spasticity |
|
|
Gabapentin
|
cental acting aminoacid analogue of GABA working on voltage gated Ca channels.
Tx of generalized tonic-clonic seizures and partial seizures |
|
|
Dantrolene
|
peripherally acting muscle relaxant preventing Ca release from SR.
Tx spasticity in UMN disorders, MS, cerebal palsy, spinal cord injury, and malignant hyperthermia |
|
|
Sugammadex
|
blocks the effects of rocuronium and vecuronium by encapulation and inactivation. Not yet FDA approved
|
|
|
Botulinum toxin
|
inhibits Ach release from NMJ
tx for upper limb spasticity onset 3-5 days, effect 3-4 months AE from toxin spreading to other systems impairing swallowing and breathing |
