Pharm Mt2

Front 1

Benzimidazoles: Spectrum, MoA, Tox

Back 1

nem, ces, trem, protozoa (not coccidia). inhibits B-tubulin dimerization. Possible teratogenicity.

Front 2

MRT

Back 2

mean residence time, how long drug remains in the system.

Front 3

Systemic drug governed by?

Back 3

FDA

Front 4

Nonsystemic drug targeting ectoparasites governed by?

Back 4

EPA

Front 5

Macrocytic Lactones: Spectrum, MoA, Tox

Back 5

Nematodes, arthropods. neuromuscular block (at chloride channel). BBB inflammation can cause leaks, not for neonates

Front 6

2 categories of ML

Back 6

avermectins, milbemycins (milbemycin, moxidectin)

Front 7

Serum half life ivermectin/milbemycin vs moxidectin

Back 7

moxidectin weeks, IVM about a day

Front 8

Concernes w/ long suboptimal period of MOX

Back 8

selects for strongest cyathostomes

Front 9

Pyrantels Spectrum, MoA, Tox

Back 9

Nematodes (cestodes in horses at 2x dose). neuromuscular block (cholinergic agonist). Very safe

Front 10

Imidazothiazoles (name 1) Spectrum, MoA, Tox

Back 10

levamisole, Nematodes. cholinergic agonist, narrow therapuetic index

Front 11

Isoqinolones (examples) Spectrum, MoA, Tox

Back 11

praziquantel, epsiprantel. tapeworms/flukes (trem/cest) neuromuscular paralysis, very low tox

Front 12

apicomplexa: what is ingested to start infection ?

Back 12

oocyst

Front 13

apicomplexa: sexual replication results in?

Back 13

oocysts

Front 14

apicomplexa: asexual replication results in?

Back 14

exponential increase (most destructive)

Front 15

when does sexual replication of apicomplexa start?

Back 15

when definitive host consumes tissue from intermediate host.

Front 16

Coccidiostats: how do they work?

Back 16

prevent dz, but not for clinical outbreaks

Front 17

Coccidiocidals: how do they work?

Back 17

hit multiple stages to cause max damage.

Front 18

2 drugs to treat coccidiosis in dogs/cats:

Back 18

sulfadimethoxine, ponazuril

Front 19

2 drugs to treat coccidiosis in calves:

Back 19

ponazuril, amprolium

Front 20

Concerns w/ sulfa drugs:

Back 20

is patient adequatly hydrated or it will form crystalsin kidneys

Front 21

Toxoplasma 2 treatments

Back 21

clind/doxy for systemic, sulfa/ponazuril for GI phase

Front 22

Crypto Tx

Back 22

Nitazoxanide

Front 23

Giardia Tx 1st and 2nd choices

Back 23

FBZ 1st, then nitazoxanide as a second choice

Front 24

FDA label claim

Back 24

90% or better for period stated

Front 25

EPA label claim:

Back 25

90% activity one time, and activity during stated time period

Front 26

FDA jursidiction for what products? (4)

Back 26

ML, nitenpyram, spinosad, oral/injectable IGR

Front 27

Lufenuron and Methoprene examples of ?

Back 27

IGRs

Front 28

Pyrethrin/pyrethroid MoA

Back 28

Cl channel blocker

Front 29

Neonicotnoids MoA, kinds (3)

Back 29

act at nicotinic cholinergic recepors in arthropods. nitenpyram, imidacloprid, spinosad

Front 30

Imidacloprid, MoA, uses

Back 30

cholinergic sites, arthropods (not ticks)

Front 31

Spinosad effective for 30d?

Back 31

drops below 100% at d30, so may selective for resistance

Front 32

Fipronyl, MoA, uses, tox

Back 32

Cl channels, ticks/fleas, rabbits

Front 33

Metaflumazone uses

Back 33

insecticide

Front 34

Amitraz, uses

Back 34

only ticks/mites

Front 35

MoA for IGRs

Back 35

block developmental stage

Front 36

Mitotic index

Back 36

# cells replicating/given field

Front 37

Growth fraction

Back 37

% proliferating (in G1 vs G0)

Front 38

short DT, high GF, and High MI usually assoc w/ lg or sm tumor?

Back 38

small tumor