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10 Cards in this Set

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ASA
MOA: irreversible acetylation of COX
low dose decreases plt aggregation (through COX-1)
intermediate dose: anti-fever/pain
High dose: anti-inflamm
toxicity: GI, chronic use (ARF, interstitial nephritis, UGI bleed), Reye's syndrome
Ibuprofen
Naproxen
Indomethacin
Ketorolac
REVERSIBLE COX inhibitor
use: anti-fever, pain, inflamm
Indomethacin closes PDA
Toxicity: renal damage, aplastic anemia, GI distress/ulcers
Celecoxib
Reversible COX-2 inhibitor (in inflamm. cells, endothelium)
Use: RA, osteoarthritis
Toxicity: increases risk of thrombosis. sulfa allergy.
acetaminophen
reversible COX inhibitor (mostly in CNS, with peripheral inactivation)
use: anti-fever/pain, NOT anti-inflamm.
toxicity: hepatic necrosis
Etidronate
Pamidronate
Alendronate
Risedronate
MOS: bisphosphonates; inhibits osteoclasts; reduces formation/resorption of hydroxyapatite
use: hypercalcemia 2/2 malignancy, Paget's, p/menop. osteoporosis
toxicity: corrosive esophagitis, nausea, diarrhea
Colchicine
ACUTE gout.
stabilizes tubulin to prevent polymerization of microtubules (prevent leukocyte chemotaxis/degranulation)
Toxicity: affects GI mucosa; can have BM suppression, myo/neuropathy (if renal/hepatic insuff)
Probenecid
Sulfinpyrazone
Chronic gout.
Inhibits uric acid reabsorption in PCT (also inhibits PCN secretion)
Allopurinol
Chronic gout.
Inhibits xanthine oxidase (xanthine--> uric acid)
use: tumor-lysis urate nephropathy
increases 6-MP and azathioprine concentrations (normally metabolized by x. oxidase)
EtanerCEPT
human TNF reCEPTor + IgG
binds to TNF
use: RA, psoriasis, ankylosing spondylitis
Infliximab
Anti-TNF Ab
use: Crohn's, RA, ankylosing spondylitis
toxicity: predisposes to infection (latent TB reactivation)