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10 Cards in this Set
- Front
- Back
ASA
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MOA: irreversible acetylation of COX
low dose decreases plt aggregation (through COX-1) intermediate dose: anti-fever/pain High dose: anti-inflamm toxicity: GI, chronic use (ARF, interstitial nephritis, UGI bleed), Reye's syndrome |
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Ibuprofen
Naproxen Indomethacin Ketorolac |
REVERSIBLE COX inhibitor
use: anti-fever, pain, inflamm Indomethacin closes PDA Toxicity: renal damage, aplastic anemia, GI distress/ulcers |
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Celecoxib
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Reversible COX-2 inhibitor (in inflamm. cells, endothelium)
Use: RA, osteoarthritis Toxicity: increases risk of thrombosis. sulfa allergy. |
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acetaminophen
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reversible COX inhibitor (mostly in CNS, with peripheral inactivation)
use: anti-fever/pain, NOT anti-inflamm. toxicity: hepatic necrosis |
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Etidronate
Pamidronate Alendronate Risedronate |
MOS: bisphosphonates; inhibits osteoclasts; reduces formation/resorption of hydroxyapatite
use: hypercalcemia 2/2 malignancy, Paget's, p/menop. osteoporosis toxicity: corrosive esophagitis, nausea, diarrhea |
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Colchicine
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ACUTE gout.
stabilizes tubulin to prevent polymerization of microtubules (prevent leukocyte chemotaxis/degranulation) Toxicity: affects GI mucosa; can have BM suppression, myo/neuropathy (if renal/hepatic insuff) |
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Probenecid
Sulfinpyrazone |
Chronic gout.
Inhibits uric acid reabsorption in PCT (also inhibits PCN secretion) |
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Allopurinol
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Chronic gout.
Inhibits xanthine oxidase (xanthine--> uric acid) use: tumor-lysis urate nephropathy increases 6-MP and azathioprine concentrations (normally metabolized by x. oxidase) |
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EtanerCEPT
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human TNF reCEPTor + IgG
binds to TNF use: RA, psoriasis, ankylosing spondylitis |
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Infliximab
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Anti-TNF Ab
use: Crohn's, RA, ankylosing spondylitis toxicity: predisposes to infection (latent TB reactivation) |