Pharm Misc

Front 1

Pharm misc

Toxin: Acetaminophen

What is the antidote/Rx?

Back 1

N-acetylcysteine

Front 2

Pharm misc

Toxin: Salicylates

What is the antidote/Rx?

Back 2

Alkalinize urine, dialysis

Front 3

Pharm misc

Toxin: Anticholinesterases, organophosphates

What is the antidote/Rx?

Back 3

Atropine, pralidoxime

Front 4

Pharm misc

Toxin: Antimuscarinic, anticholinergic agents

What is the antidote/Rx?

Back 4

Physostigmine salicylate

Front 5

Pharm misc

Toxin: Beta-blockers

What is the antidote/Rx?

Back 5

Glucagon

Front 6

Pharm misc

Toxin: Digitalis

What is the antidote/Rx?

Back 6

Stop dig, normalize K+, lidocaine, anti-dig Fab fragments, Mg2+

Front 7

Pharm misc

Toxin: Iron

What is the antidote/Rx?

Back 7

Deferoxamine

Front 8

Pharm misc

Toxin: Lead

What is the antidote/Rx?

Back 8

CaEDTA, dimercaprol, succimer, penicillamine

Front 9

Pharm misc

Toxin: Arsenic, mercury, gold

What is the antidote/Rx?

Back 9

Dimercaprol (BAL), succimer

Front 10

Pharm misc

Toxin: Copper, arsenic, gold

What is the antidote/Rx?

Back 10

Penicillamine

Front 11

Pharm misc

Toxin: Cyanide

What is the antidote/Rx?

Back 11

Nitrite, hydroxocobalamin,thiosulfate

Front 12

Pharm misc

Toxin: Methemoglobin

What is the antidote/Rx?

Back 12

Methylene blue

Front 13

Pharm misc

Toxin: Carbon monoxide

What is the antidote/Rx?

Back 13

100% O2, hyperbaric O2

Front 14

Pharm misc

Toxin: Methanol, ethylene glycol (antifreeze)

What is the antidote/Rx?

Back 14

Ethanol, dialysis, fomepizole

Front 15

Pharm misc

Toxin: Opioids

What is the antidote/Rx?

Back 15

Naloxone/naltrexone

Front 16

PHARM MISC

TOXIN: Benzodiazepines

What is the antidote / RX?

Back 16

Flumazenil

Front 17

PHARM MISC

Toxin: TCAs

What is the antidote/Rx?

Back 17

NaHCO3 (nonspecific)

Front 18

PHARM MISC

Toxin: Heparin

What is the antidote/Rx?

Back 18

Protamine

Front 19

PHARM MISC

Toxin: Warfarin

What is the antidote/Rx?

Back 19

Vitamin K, fresh frozen plasma

Front 20

PHARM MISC

Toxin: tPA, streptokinase

What is the antidote/Rx?

Back 20

Aminocaproic acid

Front 21

PHARM MISC

LEAD Poisoning?

Rx? (2)

Back 21

Lead Lines on gingivae and on epiphyses of long bones on e-ray.
Encephalopathy and Erythrocyte basophilic stippling.
Abdominal colic and sideroblastic Anemia.
Drops - wrist & foot drop. Rx: Dimercaprol & EDTA 1st line of treatment.
Succimer for kids = It 'sucks' to be a kid who eats lead.
High risk in houses with chipped paint.

Front 22

PHARM MISC
Drug reactions by system

Cardiovascular:

Atropine-like side effects?

Back 22

Caused by:

Tricyclics

Front 23

PHARM MISC
Drug reactions by system

Cardiovascular:

Cardiac toxicity

Back 23

Caused by:

Doxorubicin (Adrianmycin), daumorubicin

Front 24

PHARM MISC
Drug reactions by system

Cardiovascular:

Coronary vasospasm

Back 24

Caused by:

Cocaine

Front 25

PHARM MISC
Drug reactions by system

Cardiovascular:

Cutancous flushing

Back 25

Caused by:

Niacin, Ca2+ channel blockers, adenosine, vancomycin

Front 26

PHARM MISC
Drug reactions by system

Cardiovascular:

Torsades des pointes

Back 26

Caused by:

Class III (sotalol), class 1A (quinidine) antiarrhythmics, cisapride

Front 27

PHARM MISC
Drug reactions by system

Hematologic:

Agranulocytosis

Back 27

Caused by:

Clozapine, carbamazepine, colchicine

Front 28

PHARM MISC
Drug reactions by system

Hematologic:

Aplastic anemia

Back 28

Caused by:

Chloramphenicol, benzene, NSAIDs

Front 29

PHARM MISC
Drug reactions by system

Hematologic:

Gray baby syndrome

Back 29

Caused by:

Chloramphenicol

Front 30

PHARM MISC
Drug reactions by system

Hematologic:

Hemolysis in C6PD-deficient patients

Back 30

Caused by:

Sulfonamides, isoniazid (INH), aspirin, ibuprofen, primaquine, nitrofurantoin

Front 31

PHARM MISC
Drug reaction by system

Hematologic:

Thrombotic complications

Back 31

Caused by:

OCPs (e.g., estrogens & progestins)

Front 32

PHARM MISC
Drug reaction by system

Respiratory:

Cough

Back 32

Caused by:

ACE inhibitors (losartan - no cough)

Front 33

PHARM MISC
Drug reaction by system

Respiratory:

Pulmonary fibrosis

Back 33

Caused by:

Blcomycin, amiodarone, busulfan

Front 34

PHARM MISC
Drug reaction by system

GI:

Acute cholestatic hepatitis

Back 34

Caused by:

Macrolides

Front 35

PHARM MISC
Drug reaction by system

GI:

Focal to massive hepatic necrosis

Back 35

Caused by:

Halothane, valproic acid, acetaminophen, Amanita phalloides

Front 36

PHARM MISC
Drug reaction by system

GI:

Hepatitis

Back 36

Caused by:

INH

Front 37

PHARM MISC
Drug reaction by system

GI:

Pseudomembranous colitis

Back 37

Caused by:

Clindamycin, ampicillin

Front 38

PHARM MISC
Drug reaction by system

Reproductive/endocrine:

Adrenocortical insufficiency

Back 38

Caused by:

Glucocorticoid withdrawal (HPA suppression)

Front 39

PHARM MISC
Drug reaction by system

Reproductive/endocrine:

Gynecomastia

Back 39

Caused by:

Spironolactone, Digitalis, Cimetidine, chronic Alcohol use, estrogens, Ketoconazole (Some Drugs Create Awesome Knockers)

Front 40

PHARM MISC
Drug reaction by system

Reproductive/endocrine:

Hot flashes

Back 40

Caused by:

Tamoxifen

Front 41

PHARM MISC

Drug reaction by system

Musculoskeletal/connective tissue:

Gingival hyperplasia

Back 41

Caused by:

Phenytoin

Front 42

PHARM MISC

Drug reaction by system

Musculoskeletal/connective tissue:

Ostcoporosis

Back 42

Caused by:

Corticosteroids, heparin

Front 43

PHARM MISC

Drug reaction by system

Musculoskeletal/connective tissue:

Photosensitivity

Back 43

Caused by:

Sulfonamides, Amiodarone, Tetracycline
(SAT for a photo)

Front 44

PHARM MISC

Drug reaction by system

Musculoskeletal/connective tissue:

SLE-like syndrome

Back 44

Caused by:

Hydralazinc, INH, Procainamide, Phenytoin
(it's not HIPP to have lupus)

Front 45

PHARM MISC

Drug reaction by system

Musculoskeletal/connective tissue:

Tendonitis, tendon rupture, and cartilage damage (kids)

Back 45

Caused by:

Fluoroquinolones

Front 46

PHARM MISC

Drug reaction by system

Renal:

Fanconi's syndrome?

Back 46

Caused by:

Expired tetracycline

Front 47

PHARM MISC

Drug reaction by system

Renal:

Interstitial nephritis?

Back 47

Caused by:

Methicillin

Front 48

PHARM MISC

Drug reaction by system

Renal:

Hemorrhagic cystitis?

Back 48

Caused by:

Cyclophosphamide, ifosfamide

Front 49

PHARM MISC

Drug reaction by system

Neurologic:

Cinchonism?

Back 49

Caused by:

Quinidine, quinine

Front 50

PHARM MISC

Drug reaction by system

Neurologic:

Diabetes insipidus?

Back 50

Caused by:

Lithium, demeclocycline

Front 51

PHARM MISC

Drug reaction by system

Neurologic:

Seizures?

Back 51

Caused by:

Bupropion, imipenem / cilastatin

Front 52

PHARM MISC

Drug reaction by system

Neurologic:

Tardive syskinesia

Back 52

Caused by:

Antipsychotics

Front 53

PHARM MISC

Drug reaction by system

Multiorgan:
Disulfiram-like reaction

Back 53

Caused by:
Metronidazole, certain cephalosporins, procarbazine, sulfonylureas

Front 54

PHARM MISC

Drug reaction by system
Multiorgan:

Nephrotoxicity/neurotoxicity

Back 54

Caused by:

Polymyxins

Front 55

PHARM MISC

Drug reaction by system

Multiorgan:

Neprotoxicity/ototoxicity

Back 55

Caused by:

Aminoglycosides, loop diuretics, cisplatin

Front 56

PHARM MISC
P-450 interactions

Inducers?

Back 56

Quinidine
Barbiturates
Phenytoin
Rifampin
Griscofulvin
Carbamazepine
St. John's wort
Inducers: Queen Barb takes Phen-phen and Refuses Greasy Carbs

Front 57

PHARM MISC
P-450 interactions

Inhibitors?

Back 57

Isoniazid
Sulfonamides
Cimetidine
Ketoconazole
Erythromycin
Grapefruit juice
Inhibitors: Inhibitors Stop Cyber-Kids from Eating Grapefruit

Front 58

Path

This condition is assoc with what neoplasm(s):

Down Syndrome

Back 58

ALL (we ALL fall Down)
AML

Front 59

Path

This condition is assoc with what neoplasm(s):

Xeroderma pigmentosum, albinism

Back 59

Melanoma and basal, squamous cell carcinoma of skin

Front 60

Path

This condition is assoc with what neoplasm(s):

Chronic atrophic gastritis, pernicious anemia, postsurgical gastric remnants

Back 60

Gastric adenocarcinoma

Front 61

Path

This condition is assoc with what neoplasm(s):

Tuberous sclerosis (facial angiofibroma, seizures, mental retardation)

Back 61

Astrocytoma and cardiac rhabdomyoma

Front 62

Path

This condition is assoc with what neoplasm(s):

Actinic keratosis

Back 62

Squamous cell carcinoma of skin

Front 63

Path

This condition is assoc with what neoplasm(s):

Barrett's esophagus (chronic GI reflux)

Back 63

Esophageal adenocarcinoma

Front 64

Path

This condition is assoc with what neoplasm(s):

Plummer-Vison syndrome (atrophic glossitis, esophageal webs, anemia; all due to iron deficiency)

Back 64

Squamous cell carcinoma of esophagus

Front 65

Path

This condition is assoc with what neoplasm(s):

Cirrhosis (alcoholic, hepatitis B or C)

Back 65

Hepatocellular carcinoma

Front 66

Path

This condition is assoc with what neoplasm(s):

Ulcerative colitis

Back 66

Colonic adenocarcinoma

Front 67

Path

This condition is assoc with what neoplasm(s):

Paget's disease of bone

Back 67

Secondary osteosarcoma and fibrosarcoma

Front 68

Path

This condition is assoc with what neoplasm(s):

Immunodeficiency states

Back 68

Malignant lymphomas

Front 69

Path

This condition is assoc with what neoplasm(s):

AIDS

Back 69

Aggressive malignant lymphomas (non-Hodgkin's and Kaposi's sarcoma)

Front 70

Path

This condition is assoc with what neoplasm(s):

Autoimmune diseases (e.g., Hashimoto's thyroiditis, myasthenia gravis)

Back 70

Benign and malignant thymomas

Front 71

Path

This condition is assoc with what neoplasm(s):

Acanthosis nigricans (hyperpigmentation and epidermal thickening

Back 71

Visceral malignancy (stomach, lung, breast, uterus)

Front 72

Path

This condition is assoc with what neoplasm(s):

Dysplastic nevus

Back 72

Malignant melanoma

Front 73

PATH

Oncogene assoc tumor:

abl?

Back 73

CML

Front 74

PATH

Oncogene assoc tumor:

c-myc

Back 74

Burkitt's lymphoma

Front 75

PATH

Oncogene assoc tumor:

bcl-2

Back 75

Follicular and undifferentiated lymphomas (inhibits apoptosis)

Front 76

PATH

Oncogene assoc tumor:

erb-B2

Back 76

Breast, ovarian, and gastric carcinomas

Front 77

PATH

Oncogene assoc tumor:

ras

Back 77

Colon carcinoma

Front 78

PATH

Oncogene assoc tumor:

L-myc

Back 78

Lung tumor

Front 79

PATH

Oncogene assoc tumor:

N-myc

Back 79

Neuroblastoma

Front 80

PATH

Oncogene assoc tumor:

ret

Back 80

Multiple endocrine neoplasia (MEN) types II and III

Front 81

PATH

Tumor suppressor genes are assoc with which chromosome & tumor(s):

Rb

Back 81

13q

Retinoblastoma, osteosarcoma

Front 82

PATH

Tumor suppressor genes are assoc with which chromosome & tumor(s):

BRCA1 and 2

Back 82

17q, 13q

Breast and ovarian cancer

Front 83

PATH

Tumor suppressor genes are assoc with which chromosome & tumor(s):

p53

Back 83

17p

Most human cancers, Li-Fraumeni syndrome

Front 84

PATH

Tumor suppressor genes are assoc with which chromosome & tumor(s):

p16

Back 84

9p

Melanoma

Front 85

PATH

Tumor suppressor genes are assoc with which chromosome & tumor(s):

APC

Back 85

5q

Colorectal cancer

Front 86

PATH

Tumor suppressor genes are assoc with which chromosome & tumor(s):

WTI

Back 86

11q

Wilms' tumor

Front 87

PATH

Tumor suppressor genes are assoc with which chromosome & tumor(s):

NFI

Back 87

17q

Neurofibromatosis type 1

Front 88

PATH

Tumor suppressor genes are assoc with which chromosome & tumor(s):

NF2

Back 88

22q

Neurofibromatosis type 2

Front 89

PATH

Tumor suppressor genes are assoc with which chromosome & tumor(s):

DPC

Back 89

18q

Pancreatic cancer

Front 90

PATH

Tumor suppressor genes are assoc with which chromosome & tumor(s):

DCC

Back 90

18q

Colon cancer

Front 91

PATH

Tumor marker associations:

PSA (prostatic acid phosphatase)?

Back 91

Prostate-specific antigen. Prostatic carcinoma. Used for screening.

Front 92

PATH

Tumor marker associations:

CEA?

Back 92

Carcinoembryonic antigen. Very nonspecific but produced by approx 70% of colorectal and pancreatic cancers; also produced by gastric and breast carcinomas.

Front 93

PATH

Tumor marker associations:

alpha-fetoprotein?

Back 93

Normally made by fetus. Hepatocellular carcinomas. Nonseminomatous germ cell tumors of the testis (e.g., yolk sac tumor).

Front 94

PATH

Tumor marker associations:

beta-hCG?

Back 94

Hydatidiform moles, Choriocarcinomas, and Gestational trophoblastic tumors.

Front 95

PATH

Tumor marker associations:

CA-125?

Back 95

Ovarian, malignant epithelial tumors.

Front 96

PATH

Tumor marker associations:

S-100?

Back 96

Melanoma, neural tumors, astrocytomas.

Front 97

PATH

Tumor marker associations:

Alkaline phosphatase?

Back 97

Metastases to bone, obstructive biliary disease, Paget's disease of bone.

Front 98

PATH

Tumor marker associations:

Bombesin?

Back 98

Neuroblastoma, lung and gastric cancer.

Front 99

PATH

Tumor marker associations:

TRAP?

Back 99

Tartrate-resistant acid phosphatase. Hairy cell leukemia--a B-cell neoplasm.

Front 100

PATH

Tumor marker associations:

CA-19-9?

Back 100

Pancreatic adenocarcinoma

Front 101

PATH

Virus is assoc with what cancer:

HTLV-1?

Back 101

Adult T-cell leukemia

Front 102

PATH

Virus is assoc with what cancer:

HBV, HCV ?

Back 102

Hepatocellular carcinoma

Front 103

PATH

Virus is assoc with what cancer:

EBV?

Back 103

Burkitt's lymphoma, nasopharyngeal carcinoma

Front 104

PATH

Virus is assoc with what cancer:

HPV?

Back 104

Cervical carcinoma (16, 18), penile/anal carcinoma

Front 105

PATH

Virus is assoc with what cancer:

HHV-8? (Kaposi's sarcoma-associated herpesvirus)

Back 105

Kaposi's sarcoma, body cavity fluid B-cell lymphoma

Front 106

PATH

Tumor marker associations:

How are tumor markers used?

Back 106

Tumor markers should not be used as the primary tool for cancer diagnosis. They may be used to confirm diagnosis, to monitor for tumor recurrence, and to monitor response to therapy.

Front 107

PATH

Chemical carcinogens effect which organ(s):

Aflatoxins?

Back 107

Liver (hepatocellular carcinoma)

Front 108

PATH

Chemical carcinogens effect which organ(s):

Vinyl chloride?

Back 108

Liver (angiosarcoma)

Front 109

PATH

Chemical carcinogens effect which organ(s):

CCl4?

Back 109

Liver (centrilobular necrosis, fatty change)

Front 110

PATH

Chemical carcinogens effect which organ(s):

Nitrosamines?

Back 110

Esophagus, stomach

Front 111

PATH

Chemical carcinogens effect which organ(s):

Cigarette smoke?

Back 111

Larynx, lung

Front 112

PATH

Chemical carcinogens effect which organ(s):

Asbestos?

Back 112

Lung (mesothelioma and bronchogenic carcinoma)

Front 113

PATH

Chemical carcinogens effect which organ(s):

Arsenic?

Back 113

Skin (squamous cell carcinoma)

Front 114

PATH

Chemical carcinogens effect which organ(s):

Naphthalene (aniline) dyes?

Back 114

Bladder (transitional cell carcinoma)

Front 115

PATH

Chemical carcinogens effect which organ(s):

Alkylating agents?

Back 115

Blood (leukemia)