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115 Cards in this Set

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Pharm misc

Toxin: Acetaminophen

What is the antidote/Rx?
N-acetylcysteine
Pharm misc

Toxin: Salicylates

What is the antidote/Rx?
Alkalinize urine, dialysis
Pharm misc

Toxin: Anticholinesterases, organophosphates

What is the antidote/Rx?
Atropine, pralidoxime
Pharm misc

Toxin: Antimuscarinic, anticholinergic agents

What is the antidote/Rx?
Physostigmine salicylate
Pharm misc

Toxin: Beta-blockers

What is the antidote/Rx?
Glucagon
Pharm misc

Toxin: Digitalis

What is the antidote/Rx?
Stop dig, normalize K+, lidocaine, anti-dig Fab fragments, Mg2+
Pharm misc

Toxin: Iron

What is the antidote/Rx?
Deferoxamine
Pharm misc

Toxin: Lead

What is the antidote/Rx?
CaEDTA, dimercaprol, succimer, penicillamine
Pharm misc

Toxin: Arsenic, mercury, gold

What is the antidote/Rx?
Dimercaprol (BAL), succimer
Pharm misc

Toxin: Copper, arsenic, gold

What is the antidote/Rx?
Penicillamine
Pharm misc

Toxin: Cyanide

What is the antidote/Rx?
Nitrite, hydroxocobalamin,thiosulfate
Pharm misc

Toxin: Methemoglobin

What is the antidote/Rx?
Methylene blue
Pharm misc

Toxin: Carbon monoxide

What is the antidote/Rx?
100% O2, hyperbaric O2
Pharm misc

Toxin: Methanol, ethylene glycol (antifreeze)

What is the antidote/Rx?
Ethanol, dialysis, fomepizole
Pharm misc

Toxin: Opioids

What is the antidote/Rx?
Naloxone/naltrexone
PHARM MISC

TOXIN: Benzodiazepines

What is the antidote / RX?
Flumazenil
PHARM MISC

Toxin: TCAs

What is the antidote/Rx?
NaHCO3 (nonspecific)
PHARM MISC

Toxin: Heparin

What is the antidote/Rx?
Protamine
PHARM MISC

Toxin: Warfarin

What is the antidote/Rx?
Vitamin K, fresh frozen plasma
PHARM MISC

Toxin: tPA, streptokinase

What is the antidote/Rx?
Aminocaproic acid
PHARM MISC

LEAD Poisoning?

Rx? (2)
Lead Lines on gingivae and on epiphyses of long bones on e-ray.
Encephalopathy and Erythrocyte basophilic stippling.
Abdominal colic and sideroblastic Anemia.
Drops - wrist & foot drop. Rx: Dimercaprol & EDTA 1st line of treatment.
Succimer for kids = It 'sucks' to be a kid who eats lead.
High risk in houses with chipped paint.
PHARM MISC
Drug reactions by system

Cardiovascular:

Atropine-like side effects?
Caused by:

Tricyclics
PHARM MISC
Drug reactions by system

Cardiovascular:

Cardiac toxicity
Caused by:

Doxorubicin (Adrianmycin), daumorubicin
PHARM MISC
Drug reactions by system

Cardiovascular:

Coronary vasospasm
Caused by:

Cocaine
PHARM MISC
Drug reactions by system

Cardiovascular:

Cutancous flushing
Caused by:

Niacin, Ca2+ channel blockers, adenosine, vancomycin
PHARM MISC
Drug reactions by system

Cardiovascular:

Torsades des pointes
Caused by:

Class III (sotalol), class 1A (quinidine) antiarrhythmics, cisapride
PHARM MISC
Drug reactions by system

Hematologic:

Agranulocytosis
Caused by:

Clozapine, carbamazepine, colchicine
PHARM MISC
Drug reactions by system

Hematologic:

Aplastic anemia
Caused by:

Chloramphenicol, benzene, NSAIDs
PHARM MISC
Drug reactions by system

Hematologic:

Gray baby syndrome
Caused by:

Chloramphenicol
PHARM MISC
Drug reactions by system

Hematologic:

Hemolysis in C6PD-deficient patients
Caused by:

Sulfonamides, isoniazid (INH), aspirin, ibuprofen, primaquine, nitrofurantoin
PHARM MISC
Drug reaction by system

Hematologic:

Thrombotic complications
Caused by:

OCPs (e.g., estrogens & progestins)
PHARM MISC
Drug reaction by system

Respiratory:

Cough
Caused by:

ACE inhibitors (losartan - no cough)
PHARM MISC
Drug reaction by system

Respiratory:

Pulmonary fibrosis
Caused by:

Blcomycin, amiodarone, busulfan
PHARM MISC
Drug reaction by system

GI:

Acute cholestatic hepatitis
Caused by:

Macrolides
PHARM MISC
Drug reaction by system

GI:

Focal to massive hepatic necrosis
Caused by:

Halothane, valproic acid, acetaminophen, Amanita phalloides
PHARM MISC
Drug reaction by system

GI:

Hepatitis
Caused by:

INH
PHARM MISC
Drug reaction by system

GI:

Pseudomembranous colitis
Caused by:

Clindamycin, ampicillin
PHARM MISC
Drug reaction by system

Reproductive/endocrine:

Adrenocortical insufficiency
Caused by:

Glucocorticoid withdrawal (HPA suppression)
PHARM MISC
Drug reaction by system

Reproductive/endocrine:

Gynecomastia
Caused by:

Spironolactone, Digitalis, Cimetidine, chronic Alcohol use, estrogens, Ketoconazole (Some Drugs Create Awesome Knockers)
PHARM MISC
Drug reaction by system

Reproductive/endocrine:

Hot flashes
Caused by:

Tamoxifen
PHARM MISC

Drug reaction by system

Musculoskeletal/connective tissue:

Gingival hyperplasia
Caused by:

Phenytoin
PHARM MISC

Drug reaction by system

Musculoskeletal/connective tissue:

Ostcoporosis
Caused by:

Corticosteroids, heparin
PHARM MISC

Drug reaction by system

Musculoskeletal/connective tissue:

Photosensitivity
Caused by:

Sulfonamides, Amiodarone, Tetracycline
(SAT for a photo)
PHARM MISC

Drug reaction by system

Musculoskeletal/connective tissue:

SLE-like syndrome
Caused by:

Hydralazinc, INH, Procainamide, Phenytoin
(it's not HIPP to have lupus)
PHARM MISC

Drug reaction by system

Musculoskeletal/connective tissue:

Tendonitis, tendon rupture, and cartilage damage (kids)
Caused by:

Fluoroquinolones
PHARM MISC

Drug reaction by system

Renal:

Fanconi's syndrome?
Caused by:

Expired tetracycline
PHARM MISC

Drug reaction by system

Renal:

Interstitial nephritis?
Caused by:

Methicillin
PHARM MISC

Drug reaction by system

Renal:

Hemorrhagic cystitis?
Caused by:

Cyclophosphamide, ifosfamide
PHARM MISC

Drug reaction by system

Neurologic:

Cinchonism?
Caused by:

Quinidine, quinine
PHARM MISC

Drug reaction by system

Neurologic:

Diabetes insipidus?
Caused by:

Lithium, demeclocycline
PHARM MISC

Drug reaction by system

Neurologic:

Seizures?
Caused by:

Bupropion, imipenem / cilastatin
PHARM MISC

Drug reaction by system

Neurologic:

Tardive syskinesia
Caused by:

Antipsychotics
PHARM MISC

Drug reaction by system

Multiorgan:
Disulfiram-like reaction
Caused by:
Metronidazole, certain cephalosporins, procarbazine, sulfonylureas
PHARM MISC

Drug reaction by system
Multiorgan:

Nephrotoxicity/neurotoxicity
Caused by:

Polymyxins
PHARM MISC

Drug reaction by system

Multiorgan:

Neprotoxicity/ototoxicity
Caused by:

Aminoglycosides, loop diuretics, cisplatin
PHARM MISC
P-450 interactions

Inducers?
Quinidine
Barbiturates
Phenytoin
Rifampin
Griscofulvin
Carbamazepine
St. John's wort
Inducers: Queen Barb takes Phen-phen and Refuses Greasy Carbs
PHARM MISC
P-450 interactions

Inhibitors?
Isoniazid
Sulfonamides
Cimetidine
Ketoconazole
Erythromycin
Grapefruit juice
Inhibitors: Inhibitors Stop Cyber-Kids from Eating Grapefruit
Path

This condition is assoc with what neoplasm(s):

Down Syndrome
ALL (we ALL fall Down)
AML
Path

This condition is assoc with what neoplasm(s):

Xeroderma pigmentosum, albinism
Melanoma and basal, squamous cell carcinoma of skin
Path

This condition is assoc with what neoplasm(s):

Chronic atrophic gastritis, pernicious anemia, postsurgical gastric remnants
Gastric adenocarcinoma
Path

This condition is assoc with what neoplasm(s):

Tuberous sclerosis (facial angiofibroma, seizures, mental retardation)
Astrocytoma and cardiac rhabdomyoma
Path

This condition is assoc with what neoplasm(s):

Actinic keratosis
Squamous cell carcinoma of skin
Path

This condition is assoc with what neoplasm(s):

Barrett's esophagus (chronic GI reflux)
Esophageal adenocarcinoma
Path

This condition is assoc with what neoplasm(s):

Plummer-Vison syndrome (atrophic glossitis, esophageal webs, anemia; all due to iron deficiency)
Squamous cell carcinoma of esophagus
Path

This condition is assoc with what neoplasm(s):

Cirrhosis (alcoholic, hepatitis B or C)
Hepatocellular carcinoma
Path

This condition is assoc with what neoplasm(s):

Ulcerative colitis
Colonic adenocarcinoma
Path

This condition is assoc with what neoplasm(s):

Paget's disease of bone
Secondary osteosarcoma and fibrosarcoma
Path

This condition is assoc with what neoplasm(s):

Immunodeficiency states
Malignant lymphomas
Path

This condition is assoc with what neoplasm(s):

AIDS
Aggressive malignant lymphomas (non-Hodgkin's and Kaposi's sarcoma)
Path

This condition is assoc with what neoplasm(s):

Autoimmune diseases (e.g., Hashimoto's thyroiditis, myasthenia gravis)
Benign and malignant thymomas
Path

This condition is assoc with what neoplasm(s):

Acanthosis nigricans (hyperpigmentation and epidermal thickening
Visceral malignancy (stomach, lung, breast, uterus)
Path

This condition is assoc with what neoplasm(s):

Dysplastic nevus
Malignant melanoma
PATH

Oncogene assoc tumor:

abl?
CML
PATH

Oncogene assoc tumor:

c-myc
Burkitt's lymphoma
PATH

Oncogene assoc tumor:

bcl-2
Follicular and undifferentiated lymphomas (inhibits apoptosis)
PATH

Oncogene assoc tumor:

erb-B2
Breast, ovarian, and gastric carcinomas
PATH

Oncogene assoc tumor:

ras
Colon carcinoma
PATH

Oncogene assoc tumor:

L-myc
Lung tumor
PATH

Oncogene assoc tumor:

N-myc
Neuroblastoma
PATH

Oncogene assoc tumor:

ret
Multiple endocrine neoplasia (MEN) types II and III
PATH

Tumor suppressor genes are assoc with which chromosome & tumor(s):

Rb
13q

Retinoblastoma, osteosarcoma
PATH

Tumor suppressor genes are assoc with which chromosome & tumor(s):

BRCA1 and 2
17q, 13q

Breast and ovarian cancer
PATH

Tumor suppressor genes are assoc with which chromosome & tumor(s):

p53
17p

Most human cancers, Li-Fraumeni syndrome
PATH

Tumor suppressor genes are assoc with which chromosome & tumor(s):

p16
9p

Melanoma
PATH

Tumor suppressor genes are assoc with which chromosome & tumor(s):

APC
5q

Colorectal cancer
PATH

Tumor suppressor genes are assoc with which chromosome & tumor(s):

WTI
11q

Wilms' tumor
PATH

Tumor suppressor genes are assoc with which chromosome & tumor(s):

NFI
17q

Neurofibromatosis type 1
PATH

Tumor suppressor genes are assoc with which chromosome & tumor(s):

NF2
22q

Neurofibromatosis type 2
PATH

Tumor suppressor genes are assoc with which chromosome & tumor(s):

DPC
18q

Pancreatic cancer
PATH

Tumor suppressor genes are assoc with which chromosome & tumor(s):

DCC
18q

Colon cancer
PATH

Tumor marker associations:

PSA (prostatic acid phosphatase)?
Prostate-specific antigen. Prostatic carcinoma. Used for screening.
PATH

Tumor marker associations:

CEA?
Carcinoembryonic antigen. Very nonspecific but produced by approx 70% of colorectal and pancreatic cancers; also produced by gastric and breast carcinomas.
PATH

Tumor marker associations:

alpha-fetoprotein?
Normally made by fetus. Hepatocellular carcinomas. Nonseminomatous germ cell tumors of the testis (e.g., yolk sac tumor).
PATH

Tumor marker associations:

beta-hCG?
Hydatidiform moles, Choriocarcinomas, and Gestational trophoblastic tumors.
PATH

Tumor marker associations:

CA-125?
Ovarian, malignant epithelial tumors.
PATH

Tumor marker associations:

S-100?
Melanoma, neural tumors, astrocytomas.
PATH

Tumor marker associations:

Alkaline phosphatase?
Metastases to bone, obstructive biliary disease, Paget's disease of bone.
PATH

Tumor marker associations:

Bombesin?
Neuroblastoma, lung and gastric cancer.
PATH

Tumor marker associations:

TRAP?
Tartrate-resistant acid phosphatase. Hairy cell leukemia--a B-cell neoplasm.
PATH

Tumor marker associations:

CA-19-9?
Pancreatic adenocarcinoma
PATH

Virus is assoc with what cancer:

HTLV-1?
Adult T-cell leukemia
PATH

Virus is assoc with what cancer:

HBV, HCV ?
Hepatocellular carcinoma
PATH

Virus is assoc with what cancer:

EBV?
Burkitt's lymphoma, nasopharyngeal carcinoma
PATH

Virus is assoc with what cancer:

HPV?
Cervical carcinoma (16, 18), penile/anal carcinoma
PATH

Virus is assoc with what cancer:

HHV-8? (Kaposi's sarcoma-associated herpesvirus)
Kaposi's sarcoma, body cavity fluid B-cell lymphoma
PATH

Tumor marker associations:

How are tumor markers used?
Tumor markers should not be used as the primary tool for cancer diagnosis. They may be used to confirm diagnosis, to monitor for tumor recurrence, and to monitor response to therapy.
PATH

Chemical carcinogens effect which organ(s):

Aflatoxins?
Liver (hepatocellular carcinoma)
PATH

Chemical carcinogens effect which organ(s):

Vinyl chloride?
Liver (angiosarcoma)
PATH

Chemical carcinogens effect which organ(s):

CCl4?
Liver (centrilobular necrosis, fatty change)
PATH

Chemical carcinogens effect which organ(s):

Nitrosamines?
Esophagus, stomach
PATH

Chemical carcinogens effect which organ(s):

Cigarette smoke?
Larynx, lung
PATH

Chemical carcinogens effect which organ(s):

Asbestos?
Lung (mesothelioma and bronchogenic carcinoma)
PATH

Chemical carcinogens effect which organ(s):

Arsenic?
Skin (squamous cell carcinoma)
PATH

Chemical carcinogens effect which organ(s):

Naphthalene (aniline) dyes?
Bladder (transitional cell carcinoma)
PATH

Chemical carcinogens effect which organ(s):

Alkylating agents?
Blood (leukemia)