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31 Cards in this Set
- Front
- Back
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Fever (may be confused with heat stroke), muscle rigidity, agitation, confusion, delirium, dyspnea, tachycardia, respiratory failure, acute renal failure
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Neuroleptic Malignant Syndrome
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3 things the brain needs
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O2, glucose, thiamine
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What is the max dose of acetaminophen that can be given to an adult in 24hrs
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4 grams
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What is the antidote for Acetaminophen?
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Acetylcysteine (mucomyst)
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What is the antidote for morphine or opioid overdose?
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Naloxone (Narcan)
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what are the indications for Acetaminophen?
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Fever (antipyretic) and pain (non-narcotic analgesic)
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what are the AEs of Acetaminophen?
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Hepatic failure (overdose or combination with alcohol causes liver damage), renal failure, blood dyscrasia
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where does Aspirin work to block pain?
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BOTH centrally and peripherally
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where do NSAIDS work to block pain?
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peripherally
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CIs of Aspirin
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GI disorders, renal disease, Children (causes Reye's syndrome) except for RA, and hypersensitivity reactions
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Restlessness, hallucinations, rapid BP change, loss of coordination, tachycardia, fever, increase DTRs, N/V/D
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Serotonin Syndrome
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what leads to serotonin syndrome?
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combined therapy with an SSRI and an MAOI or other drugs that potentiate serotonin neurotransmission
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Allupurinol (Zyloprim) & Colchicine (Colchicine) are used in treatment of what?
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Gout and hyperuricemia
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what are some food & drug interactions of MAOIs?
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aged cheese, wine, alcohol, caffeine, amphetamines, antihistamines, meperidine
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process and time from when drug enters body until it reaches bloodstream
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Absorption
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Transport of drug within the body from blood stream into target cell
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Distribution
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Method of inactivation or biotransformation, change lipid soluble drug to water soluble substance for excretion
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Metabolism
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Elimination of drug from body
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Excretion
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what are the main AEs of MAOIs
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hypertensive crisis and seizures!! orthostatic hypotension, constipation, dry mouth, dizziness, drowsiness, insomnia, twitching, tremor
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unexpected reaction to a drug that occurs the first time it is given
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Idiosyncratic
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AEs of TCAs - Imipramine (Tofranil)
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arrhythmias, hypotension, blurred vision, dry eyes, drowsiness, fatigue, constipation, dry mouth
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Max dose of Phenytoin (Dilantin) IV
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50 mg/min IV
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Toxic level of Phenytoin (Dilantin)
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greater than 20
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increased actylecholine and decreased dopamine
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Parkinson's disease
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what drug is used in the treatment of malignant hyperthermia?
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Dantrolene (Dantrium)
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Adrenergic, norepinephrine, dopamine
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Sympathetic
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Cholinergic, acetylcholine
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Parasympathetic
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Antiadrenergic Drugs
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VS esp apical pulse, alpha blocker = 1st dose syncope, caution with driving and w/ alcohol use, do not stop abruptly
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what race are beta blockers alone not effective in?
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African Americans
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what is the antidote for cholinergic drugs?
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Atropine
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what is the antidote for anticholinergic OD?
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Physostigmine salicylate (Antilirium) Adult dose = 2 mg Children = 0.5-1 mg
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