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19 Cards in this Set
- Front
- Back
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What is the function of phospholipase A2 in the production Prostaglandins?
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This enzyme cleaves lipids in the cell membrane to produce arachidonate?
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how can eicosanoid synthesis be inhibited?
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Inhibiting A2 or Ca+2, COX-1 and COX-2
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what does the non-enzymatic metabolism of arachidonate produce?
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isoprostanes
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what drug is an inhibitor of 5-lipoxygeanse , used for asthma?
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Zileuton
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name two leukotriene receptor blockers that are useful in treating asthma?
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zafirlukast and montelukast
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Leukotrienes are potent ______________ and also stimulate secretions?
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bronchoconstrictors
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what are the effects of PGE in the vascular beds( but not in the large veins)?
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Vasodilators, with decreased BP and results in increased flow to most organs ( heart, kidneys, mesentery )
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________ is a potent vasodilator (5 times that of PGE2)that produces decreased BP and reflex tachycardia
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PGI2
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_________is a potent vasoconstictor and increases Ca+2 and IP3/DAG. Also smooth muscle mitogen
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Thromboxane A2
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___________lower BP via microvasculature (not large vessels) and cause exudation of plasma in postcapillary venules
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Leukotrienes
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___and ___ both inhibit platelet aggregation
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PGI2 and PGE1
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___ is a potent promoter of platelet aggregation
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Thromboxane
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___,____,____ relax bronchial smooth muscle and _____ and _____ constricts
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PGE1, PGE2 and PGI relax
TXA2 and PGF2alpha constricts |
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what does PGE and PGI do on the GI ?
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They decrease acid secretions and increase mucal secretions and increase mucal blood flow to help maintain gastic intergrity
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PGE2 and PGF stimulate_______ release to contract the uterus. ______in a synthetic PGE2
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oxytocin, and Dinoprostone
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What does PGE2 and PGI do to the kidney?
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Increase kidney blood flow, promote diuresis, stimulate Na+ and K+ secretion, decrease ADH affects
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Latanoprost is used for ...
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it is a derivative of PGF2alpha, which can reduce intraocular pressure, minimal side effects
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Fever is caused by PGE but what inhibits this
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aspirin can reduce fever
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What can cause enhanced sympathetic tone
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NSAIDS action on PGE to increase NE release
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