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11 Cards in this Set

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what is the essential component of sulfa's that allows it to work?
a free para-amino group
what is the mech of action for sulfa drugs?
they are PABA agonists that inhibit the formation of bacterial DHF acid and consequently inhibit DNA production
action of Sulfa drugs
Tx: primary Tx of UTI's, Pneumocystis jiroveci, nocardiosis, toxoplasmosis, and trachoma

Good for G+ & G-

metabolized in the liver, excreted in Kidney
SE:

Kernicterus in infants
"Sulfa GIRL you dyscrasia!"
Crystaluria
Hemolytic anemia
Stevens-Johnson syndrome
Microscopic hematuria
Uses of TMP-SMX (bactrim)
DOC for uncomp UTI & Moraxella catarrhalis
widely used for otitis media
Also:
P. jiroveci pneumonia,
shigellosis,
systemic salmonella infections
prostatitis
Sulfadiazine in combination with pyrimethamine is used for?
toxoplasmosis
causes crystalluria more often than other sulfonamides
Silver Sulfadiazine
topical antiinfective for use c second- and third-degree burns
Pyrimethamine; Sulfadoxine
presumptive treatment of malaria
no longer recommended for malaria prophylaxis due to the possibility of fatal toxic epidermal necrolysis (TEN)
Sulfasalazine
metabolized to mesalamine for the Tx of ulcerative colitis
Sulfasoxazole
short acting
Sulfamethoxazole & sulfadoxine
intermediate acting
Sulfadiazine is the DOC for
Nocardia
SE
Crystaluria