Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
11 Cards in this Set
- Front
- Back
- 3rd side (hint)
|
what is the essential component of sulfa's that allows it to work?
|
a free para-amino group
|
|
|
|
what is the mech of action for sulfa drugs?
|
they are PABA agonists that inhibit the formation of bacterial DHF acid and consequently inhibit DNA production
|
|
|
|
action of Sulfa drugs
|
Tx: primary Tx of UTI's, Pneumocystis jiroveci, nocardiosis, toxoplasmosis, and trachoma
Good for G+ & G- metabolized in the liver, excreted in Kidney |
SE:
Kernicterus in infants "Sulfa GIRL you dyscrasia!" Crystaluria Hemolytic anemia Stevens-Johnson syndrome Microscopic hematuria |
|
|
Uses of TMP-SMX (bactrim)
|
DOC for uncomp UTI & Moraxella catarrhalis
widely used for otitis media Also: P. jiroveci pneumonia, shigellosis, systemic salmonella infections prostatitis |
|
|
|
Sulfadiazine in combination with pyrimethamine is used for?
|
toxoplasmosis
|
causes crystalluria more often than other sulfonamides
|
|
|
Silver Sulfadiazine
|
topical antiinfective for use c second- and third-degree burns
|
|
|
|
Pyrimethamine; Sulfadoxine
|
presumptive treatment of malaria
|
no longer recommended for malaria prophylaxis due to the possibility of fatal toxic epidermal necrolysis (TEN)
|
|
|
Sulfasalazine
|
metabolized to mesalamine for the Tx of ulcerative colitis
|
|
|
|
Sulfasoxazole
|
short acting
|
|
|
|
Sulfamethoxazole & sulfadoxine
|
intermediate acting
|
|
|
|
Sulfadiazine is the DOC for
|
Nocardia
|
SE
Crystaluria |
