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50 Cards in this Set
- Front
- Back
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Gabapentin moa
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Gabapentin GABA re-uptake |
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Tiagabine
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– Interferes with GABA re-uptake |
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Vigabatrin
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– elevates GABA levels by irreversibly inhibiting its main catabolic enzyme, GABA- transaminase |
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Oxcarbazepine |
Na K |
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Zonisamide |
Na Ca |
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Ethosuximide |
Ca
absence seizures |
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AED with known actions on K+ channels |
is valproate
Retiagabine |
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Retiagabine |
K |
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Felbamate |
Na NMDA |
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Lamotrigine |
Na Ca blocks glutamate release |
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Topiramate |
Na Cl glutamate |
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Valproate |
Na K Ca GABA |
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Cytochrome P-450 Inducers |
phenobarbital primidone phenytoin carbamazepine |
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Cytochrome P-450 Inhibitors |
valproate topiramate (CYP2C19) oxcarbazepine (CYP2C19) felbamate (CYP2C19) |
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What kind of seizures is Phenytoin for? |
partial seizures |
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Carbamazapine First line drug for |
partial seizures |
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Carbamazapine side effects |
1. CNS sedation. 2. Agranulocytosis and aplastic anemia 3. leukopenia |
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AED that stimulates its own metabolism |
Carbamazepine |
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AED used in neonates for partial seizures |
Phenobarbital |
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Is Phenobarbital a 1st or 2nd line drug? |
Second-line drug in adults due to more severe CNS sedation |
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Phenobarbital moa |
GABA
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Phenobarbital effect on P450 |
Stimulates cytochrome P-450 |
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Primidone moa |
GABA |
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Primidone metabolism |
(Primidone is Barbiturate, like phenobarbital) Metabolism:Converted to phenobarbital and phenylethyl malonamide |
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Benzodiazapines (Diazapam and clonazapam) used for: |
Status epilepticus (IV) |
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what kind of seizures is phenobarbital used for? |
partial seizures |
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Partial seizures |
CARBAMAZEPINE PHENYTOIN VALPROIC ACID |
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ABSENCE SEIZURES |
ETHOSUXIMIDE Ca VALPROIC ACID Ca CLONAZEPAM GABA |
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MYOCLONIC SEIZURES |
VALPROIC ACID CLONAZEPAM |
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Work primarily on GABA |
Benzodiazepines Barbiturates Gabapentin Tiagabine Vigabatrin
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Act Primarily on Na+ Channels |
Phenytoin, (Hydantoins) Carbamazepine, Oxcarbazepine (Tricyclics) Zonisamide |
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Act Primarily on Ca2+ Channels |
Ethosuximide |
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Act Primarily on K+ Channels |
valproate
Retiagabine |
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AED with multiple sites of action |
Felbamate Lamotrigine Topiramate Valproate
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Phenytoin First,line,drug,for, |
partial seizures |
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what's the phenytoin prodrug |
fosphenytoin |
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Phenytoin famous side effects |
gum,hyperplasia,,hirsu#sm, |
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Carbamazepine (a tricyclic, Na+) side effects |
Agranulocytosis aplastic anemia in elderly patients, rarely - transient leukopenia |
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antiepileptic used in neonates |
phenobarbital (barbiturates, GABA) Second-line drug in adults due to more severe CNS sedation |
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antiepilecptic with long half-life (4 days) |
phenobarbital |
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Primidone main use |
• Partial seizures |
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Benzodiazapines (Diazapam and clonazapam) main use |
Statusepilepticus(IV) |
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Main drugs used in Status epilepticus(IV) |
Benzodiazapines (Diazapam and clonazapam) main use |
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Paradoxical hyperexcitability in children |
Benzodiazapines (Diazapam and clonazapam) |
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Valproate (Valproic Acid) uses |
Partialseizures, first-linedrugforgeneralizedseizures. |
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Valproate moa |
GABA Na K |
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antiepileptic highly bound to protein |
valproate |
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rare but severe Hepatoxicity seen with |
valproic acid (carboxylic acid: GABA, Na, K) |
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Ethosuximide used for |
Absence seizures |
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First,line,drug,for,par#al,seizures, |
phenytoin |
