Pharm - Lecture 13 - Adrenergic Agonists

Front 1

Give the order of adrenergic receptor binding preference for the following drugs: EPI, NE, ISO

Back 1

Alpha: EPI > NE >> ISO
Beta: ISO > EPI > NE

Front 2

What are the primary sites of action for alpha-1 and alpha-2

Back 2

α1: contraction of smooth muscle (incl. VSM)
α2: presynaptic receptors ( decrease NE release)

Front 3

What are the primary sites of action for the three beta receptor subtypes?

Back 3

ß1: in heart and juxtaglomerular cells
(and some fat cells)
ß2: relaxation of smooth muscle (and skeletal mm vasculature)
ß3: some fat cells

Front 4

Describe the biphasic BP response curve for EPI administration

Back 4

Low EPI: Preferential activation of B2 leads to a decrease in peripheral resistance
High EPI: Both B2 and A1, but A1 dominates and resistance increases

Front 5

Describe the physiologic response to NE administration.

Back 5

NE essentially activates A1 only, leading to a systemic rise in vascular resistance. Since NO Bs are activated, PANS autonomic reflexes will drive a "Reflex Bradycardia" to compensate.

Front 6

How might you pretreat a patient to avoid a reflex bradycardia from NE administration?

Back 6

Atropine

Front 7

How might systemic administration of isoproterenol affect the body?

Back 7

Isoproterenol, a non-specific beta agonist, will cause:
1) A decrease in peripheral resistance (B2 mediated)
2) An increase in HR (B1 mediated)