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10 Cards in this Set
- Front
- Back
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What does Fick's law relate?
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Diffusion of molecules across a barrier.
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What four factors compose Fick's law?
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1) Concentration Gradient
2) Permeability 3) Barrier Thickness 4) Barrier Area |
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What does the Henderson-Hasselbalch equation relate?
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Protonated to unprotonated fractions of an acid or base.
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Would a weak base (pKa 7.0) most likely be charged in normal physiologic urine?
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Yes, it would be +-charged in a proton-rich environment.
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Would the administration of ammonium chloride acidify or alkalize the urine?
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Acidify.
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Define the differences between drug elimination and drug excretion.
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Elimination - conversion of a drug into an inactive form.
Excretion - removal of a drug from the body. |
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What is first-order elimination of a drug?
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First-order elimination implies the rate of elimination is proportional to the drug concentration.
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What is zero-order elimination of a drug?
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The rate of drug elimination is invariable.
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To aid renal excretion in a weak acid drug overdose, one should (alkalize or acidify) the urine.
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Weak acid excretion is aided by an alkaline urine. Administer sodium bicarbonate.
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To aid renal excretion in a weak base drug overdose, one should (alkalize or acidify) the urine.
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Weak base excretion is aided by an acidic urine. Administer ammonium chloride.
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