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7 Cards in this Set
- Front
- Back
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Thiopental
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Highly lipid soluble. Brain equilibrium occurs rapidly. Terminatino occurs by redistribution. Activate GABA receptors and inhibit excitatory AMPA receptors. Half-life of 8-10 hours and is context-sensitive. This means the longer you give a drug the longer it takes to rid of it.
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Barbituates
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Have enol and keto form. Thiopental, thiamylal, mathohexital. Sulfur groups at position 2 is what makes rapid recovery available. Ultra-short acting. Phenobarbital is long acting. Don't give in porphyrias.
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Propofol
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it killed Michael!!! Parenteral anesthetic. Hydrophobic, Produces anesthesia in single dose?? Action on GABA receptor. Point mutations can eliminate the effect. Don't compete with GABA for the receptor. Fast recovery. 2-4 minute distribution. Also is an analgesic by binding GABA. Dual action. Agonists of both. Same metabolism as morphine.
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Etomidate
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carboxylated imidazole. Hydrophobic. Redistribution is termination mech. Can get adrenal insufficiency. Minimal hemodynamic side effects.
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Ketamine
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Phencyclidine derivate which produces dissociative anesthesia. You get weird dreams. Water soluble with two isomers. Act5s on lots of different receptors. No GABA receptor though.
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Benzo's
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Diazepam, Midazolam. Bind benzo receptor. There are agonists and antagonists.
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Propofol in fusion syndrome
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Propofol in high dose can cause cardiomyopathy, cardiac failure, metabolic acidosis, myopathy, hyperkalmeia, hepatomegaly and other crappy stuff.
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