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24 Cards in this Set
- Front
- Back
- 3rd side (hint)
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Definine selectivity
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exerts only the effect for which it is given for. there would be no side effects, no drug is completley selective
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What is pharmacopeia?
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lists of all the authorized drugs in the country (first one in the US in 1820)
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what are the 5 charictoristics of a perfect drug
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easy to use
few interactions stabile easy generic name inexpensive |
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Define Pharmacokinetics
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how the body acts on the drug
Absorption Distribution Metabolism Excretion |
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Pharmacodynamics
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how the drug acts on the body
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Overall therapeautic goal
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Maximize benefit
minimize harm |
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What did the pure food and drug act of 1906 do?
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first major drug act
provided consumers info about quality officially designated pharmacopoeia |
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what did the federal food, drug and cosmetic act do?
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amended the pure food and drug act
esablished the FDA required government approval prior to marketing |
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Food and drug modernization act purpose
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fast track for AIDs and cancer drugs
6 months notice if discontinued testing on kids clinical trials for drugs for life-threatning uses |
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schedule of controlled substances I-V
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I- high abuse potential (not accepted)
II- high abuse (accepted, written scrt) III- less abuse (scrt expires 6mo) IV- less abuse (same rules) V- lower abuse (may not require scrt) |
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Steps to develope a new drug
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Preclinical (animal studys)
Clinical Phase I (healthy) phase II limited controlled eval phase III extended clincal review post-marketing surveillance (pull off market) |
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Generic name
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first letter not capitalized
simpler then chemical name |
"ibprofen"
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Trade name
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brand
easy to say and remember |
"Advil"
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Therapeutic index
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dose that has a therapeuric effect on 50% of animals
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Factors effecting absorption (8)
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route of admin.
dissolution rate blood flow absoptive surface area contact time pH cell membrance transports mech lipid solubility |
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parenteral
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outside GI tract (usually injected)
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enteral
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by way of GI tract
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Advantage to oral admin.
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ease
selfcare least $ can be retrieved |
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advantage to parenteral (outside GI)
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fast
highest most immediate (doesn't have to absorb, it is in blood already!) |
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when a drug is bound to a protein is it effective
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no, has to be unbound
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what is the P450 Enzyme System do?
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metabolizes drugs (there are different substrates of p450)
some drugs inhibit or excite p450 (this can increase/decrease other drugs) |
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Agonist receptor
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a drug that bind with and stimulates the receptor
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Antagonist receptor
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a drug that binds with and blocks action at the receptor
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Loading dose
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a higher level of dose to get the theraputic level
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