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19 Cards in this Set
- Front
- Back
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BB effects on HR, conduction velocity, refractory period
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decreased HR, decreased CV, increased RP
Also suppresses ventricular ectopic beats |
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BB effects on cardiac contractility, cardiac work and oxygen consumption
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decreased contractility, decreased work and decreased O2 consuption
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What is a result of slowing ventricular ejection and decreasing peripheral resistance?
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improved stroke volume!! great for dissecting aoritic aneurism
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BB's reduce NE-mediated cardiac _________
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hypertrophy!!
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What do BBs do to renin?
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suppress
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propranolol
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non-selective bb, like many bb's, it undergoes extensive first-pass metabolism
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metoprolol
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prototype of selective bb (A BEAM)
use in asthmatics STILL not recommended |
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atenolol
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beta1 selective .... does NOT undergo significant first pass metabolism
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pindolol
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non-selective BB, has some beta1 agonist (less cardiodepressant, less effect on serum lipids)
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labetalol
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mixture: alpha-1 & non-selective beta antagonist.....
reduces peripheral resistance with less effect on heart rate, does not effect serum lipids (used to manage hypertension in pregnant patients) |
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esmolol
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ultra-short acting beta-1 selective blocker, IV, 10 minute half life
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sotalol
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non-selective beta blocker & K+ channel blocker (for arrythmias)
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what catagory do metyldopa, clonidine, and prazosin fall into and what is the purpose?
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sympatholytics; inhibits post-ganglionic functioning of SNS
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methyldopa: how does it work?
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It acts selectively for alpha2 receptors, which are on the presynaptic neuron and decrease release of NE into synaptic cleft. ... works in CNS!
Think METHYL-NE from 1st unit |
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what is the outcome of metyldopa?
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lowers peripheral resistance w/o exerting SEs on HR, CO, renal flow, plasma volume or renin secretion. Can be used in pregnancy; other SEs are dry mouth, sedation, reduced libido, parkinson signs and hyperprolactinemia. SEs limit use.
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Clonidine is very similar to....
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methyldopa, selective alph2 agonist
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what's a major psychiatric warning associated with clonidine?
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don't give to depressed pts; TCAs may reduce antihypertensice effect; patches should NOT be administed to poorly complient patients.
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what is a selective alpha1 channel blocker/receptor antagonist?
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prazosin..... decreases arteriolar resistance and increases venous capacitance; orthostatic hypotension is most prominent SE; not recommended as monotherapy.
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Common SE of prazosin?
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50% have sudden drop in peripheral resistance, increased HR & CO, increased renin. Not recommended as monotherapy!
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