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17 Cards in this Set
- Front
- Back
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Older progestins (progesterone analogs).
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Hyper - Hydroxyprogesterone
Mothers - medroxyprogesterone May - Megestrol Die - Dimethisterone |
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Newer progestins (gonadotropin inhibitors).
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Do - Desogestral
Not - Norgestimate Guess - Gestodene |
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GnRH analogs (suppressors with continous GnRH) used for prostate cancer.
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Long - Leuprolide
Goose - Goserelin Necks - Naferelin |
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Aromatase (2) and 5-alpha-reductase inhibitors (enzyme inhibitors).
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Let's - Letrozole
Examine - Exemestane First - Finasteride |
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Progestin only contraceptive, besides mini-pills.
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Make - Medroxyprogesterone (Depo)
Eternal - Etonogestrel (Implanon) - rod Love - Levonorgestral (Mirena) - IUD |
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Synthesis inhibitor that suppresses adrenal and gonadal steroid synthesis.
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Ketoconazole - for steroid reponsive metastatis prostate cancer.
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Antimetabolite anticancer drugs work by?
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Interfering with production of nucleic acids by (CCS):
1) Inhibiting production of certain nucleic acids that inhibits replication 2) structure similarity allows them to replace pyrimidines/purines in synthesis |
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Describe folic acid anatagonists for cancer.
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- Methotrexate - inhibits DiHydroFolate Reductase that reduces DHF to tetrahydrofolate, the methyl donor for synthesis of Deoxythymidine Monophospate (nucleotide).
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What is leucovorin rescue?
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administration of a formulation of vitamin B for preventing 'collateral damage' to normal cells when using MTX, an antimetabolite, to treat cancer, which may cause BONE MARROW suppression and GI Sx
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What type of cancers is MTX used for?
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- Choriocarcimoma (germ cells)
- Acute leukemia - Bone cancer - Combo regimens |
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Name 4 mechanisms of drug resistance with all antimetabolites.
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1) Decreased drug import
2) Increased expression of drug efflux transporter 3) Mutations in enzymes (altered DHFR for less affinity MTX) 4) More synthesis (of DHFR) |
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Name 6 pyrimidine anatagonists.
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1) 5-Fluorouracil (5-FU)
2) Fluorodeoxyuridine (F-FdUrd, Floxuridine) 3) Cytarabine (Ara C, cytosan) 4) Gemcitabine (Gemzar) 5) Capecitabine (prodrug 5-FU) 6) Azacytidine |
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What is the MOA of 5-FU and 5-FdUrd?
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Directly inhibit thymidylate synthase (used to make dTMP in DNA synthesis). 5-FU is converted/incorporated into RNA instead of UTP.
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What is the MOA of Azacytidine?
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Incorporated into DNA and RNA instead of cytosine.
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What is the MOA of Cytarabine and used in what cancer?
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- Inhibits DNA polyermase
- Used in AML |
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How are Gemcitabine and Cytarabine similar in actions?
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Both inhibit DNA ploymerase but Gemcitabine is not cell-cycle-specific
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Name 5 Purine antagonists.
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1) 6-Mercaptopurine
2) 6-Thioguanine (6-TG) 3) Fludarabine (Fludara) 4) Cladribine (Leustatin) 5) Pentostatin (Deoxycorfomycin, Nipent) |
