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9 Cards in this Set
- Front
- Back
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ANP is a peptide produced in the _____ and secreted into the vascular system in response to increases in ___ intake & ____ volume expansion.
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heart, NaCl, ECF
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ANP seems to inhibit:
a. b. |
a. direct and indirect actions of angio II on BP
b. reduces renin secretion |
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4 stimuli for ANP secretion
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1. atrial stretch (volume expansion)
2. change in posture 3. exercise 4. SNS stimulation |
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endothelins are ____ peptides
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vasoconstrictor
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IV ETs cause an intial ___ in bp followed by a prolonged ___.
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decrease, increase
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ETs have direct positive ____ & ____ effects on the heart and are potent coronary ____.
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inotropic, chronotropic, vasoconstrictors
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What are the endothelin receptor subtypes and where are they?
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ETa - vascular smooth muscle (mediate vasoconstriction)
ETb - vascular endothelium (mediate vasodilation) |
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The most severe side effects of ET antagonists are ___ and ___.
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teratogenicity and fatality
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ET antagonists are used clinically to treat:
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pulmonary hypertension
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