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17 Cards in this Set
- Front
- Back
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Which receptor blockade is correlated with clinical efficacy in schitzo?
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DA, D2R
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What is special about clozapine?
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weak D2R blocker w/ decreased propensity for SEs and increased efficacy (?)
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Typical (FG) antipsych?
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chlorpromazine, haloperidol (thorazine and haldol)
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what is a really important receptor to block in schitzo??
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5HT
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Which three atypical anti-psych drugs block 5HT preferentially?
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ROC: risperidone, olanzapine, clozapine
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metabolism of ADP?
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most are incompletely, but readily absorbed
significant first pass metabolism by P450 |
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adverse effects of adps
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muscarinic and alpha blockade
cardiovascular effects: increased HR, QT prolongation (esp zip), sudden cardiac death hyperprolactinemia |
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what kind of drugs cause hyperprolactinemia?
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drugs that block dopamine.... because dopamine normally supressed prolactin
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early adverse neurological effects of apds are largly due to what?
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dopamine
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what are the adverse early effects of adps?
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dystonia, dyskathisia, parkinsonism
neuroleptic malignant syndrome rare but possible |
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what are the late appearing effects of adps? (neurologic effects that is)
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tarditive dyskinesia, extrapyramidal, weight gain common
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what are the special adverse effects of clozapine?
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agranulocytosis, seizure
DO WEEKLY BLOOD COUNTS FOR FIRST 6 MONTHS |
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General effect of blocking serotonin?
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weight gain... eat more food
(SARAH weighs a TON) |
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what are DA related effects of apds?
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hyperlactinemia & EPS
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SE: haloperidol vs chlopromazine
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hal: decreased autonomic, greater EPS & TD
chlo: increased autonomic, decreased EPS & TD |
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risp vs olan vs clo SEs
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risp: increased DA, decreased 5HT
olan: increased 5HT, decreased DA cloz: increased 5HT, more serious effects (agranulocytosis, seizures) but most efficacious |
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what is approved for kids over 5 and over 10?
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over 5: risperidone, agressive autistic
over 10: quentiapine, aripriprazole in bipolar |
