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19 Cards in this Set
- Front
- Back
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What drug binds to inhibits parasitic enzymes especially the sulfhydryl groups and it used for tx of Trypanosomiasis?
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Malarsoprol (Mel B)
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What drug is an ornithine decarboxylase inhibitor that is used for tx of late stage tryponasoma and reducing unwanted facial hair in women?
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eFLORnithine
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What drug is used in chronic trypanosoma inf. and produces intracellular free radicals that kill the organism.
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Nifurtimix (ampit)
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What drug is contraindicated with alcohol because it causes Disulfiram-like reactions ?
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Metronidazole
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What drugs disrupt DNA structure and are used in the treatment of Trichomoniasis AND Giardiasis
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Metronidazole and Trichomoniasis
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What systemic amebicide blocks chain elongation of proteins and is reserved for EXTRAintestinal amebiasis in pts who do not respond to Metro?
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Emetine and Dehydroemetine
note: CI in pregnant and can cause Cardiotoxicity (DON'T EXERCISE while taking) |
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What drugs are used in the treatment of toxoplasmosis?
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-Pyrimethamine and sulfonamide (+Leucovorin to protect against folate deficiency)
- Atovaquone |
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What drugs are used in the tx of PJP?
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- TMP-SMZ
-Pentamidine -Atovaquone -Dapsone -Eflornithine IV |
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What antimalaria medication is used clinically to eradicate latent tissue and hepatic forms responsible for relapses in P.vivax and P.ovale.
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Primaquine
- AE: anemias in patients with G6PDH deficiency, methmoglobinemia, and cyanosis. |
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What antomalaria drug is used orally for chloroquine resistant falciparum?
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Mefloquine and Quinine
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What antimalarial medication has side effects that include cinchonism (hearing, visual, CNS), OVERDOSE ABORTION, and hemolysis with pregnancy.
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Quinine
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What two drugs are combined to make Malarone?
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Atavaquone and Proguanil
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What antiworm drug inhibits microtubule synthesis in parasites?
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Mebendezole
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What drug given along with Mebendezole is used to tx roundworms and pinworms by paralyzing the stomach and releasing their hold of intestinal wall?
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Pyrantel Pamoate
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What antiworm medication is broad spectrum against strongyloides and affects parasitic microtubular aggregation?
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Thiabendazole
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What is the DOC for Onchocerciasis (river blindness) and nematodes?
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Ivermectin
-binds to parasite Cl channels |
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What drug is effective against microfilariae of Wucheria Bancrofti ?
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Diethylacarbamazine (Hetrazan)
TARZAN=ELEPHANTITIS. Filariasis may cause elephantitis by blocking lymph vessels. |
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What is the DOC for all species of Trematodes (FLUKES)?
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Praziquantel (Biltricide)
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What drug increases calcium permeability of the membranes and paralyses worm musculature?
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Praziquantel
CI in cystecercosis of the eye! |
