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23 Cards in this Set
- Front
- Back
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Which form of Amphotericin B binds to mammalian membranes LESS readily and reduce drug induced renal impairment?
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Lipid formulations
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Which antifungal is the only basa analog?
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flucytosine
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What is the MOA of flucytosine?
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Gets deaminated into 5-Fluorouracil (only in fungal cells!!) by cytosine deaminase and inhibits THYMIDYLATE synthase enzyme.
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What is the DOC for cryptococcus meningitis?
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Fluconazole + Amphotericin B.
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What is the MOA of Triazoles and Imidazoles?
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Inhibit ergosterol biosynthesis by inhibiting 14-alpha demethylase enzyme, causing an accumulation of 14-aplpha methyl sterols. This disrupts the packing of phospholipids.
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What Imidazole is a topical agent that is given as an ORAL troche 5x/day for 2 weeks in the tx of oropharyngeal candidiasis?
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ClOtrimazole
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What topical Imidazole can be given orally and systemic for cutaneous candidiasis and vulvovaginitis?
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Miconazole (monistat)
- AE: burning, skin maceration, itching. |
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Which triazole is used in the suppresive therapy of histoplasmosis in HIV seropositive patients.
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Itraconazole
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Which antifungal crosses the BBB even without inflammation?
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Fluconazole
Used for coccidioidal meningitis and cryptococcal meningitis. |
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What antifungal raises terfenidine ans astemizole levels that can decrease cardiac conduction, prolonging the QT interval and potentially causing fatal ventricular tachycardia TORSADE DE POINTES?
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KETOconazole
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What antifungal causes endocrinological disorders due to inhibition of steroid synthesis, such as decrease libido, gynecomasta, galactorrhea, and STILL BIRTHS.
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KETOconazole
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What antifungal is the DOC for oral candidiasis (moniliasis), thrush, and denture stomatitis?
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Nystatin
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What antifungal is givel orally but leaves a terrible foul taste for 7-10 days and it too toxic to be given systemic?
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Nystatin
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Which antifungal crosses the BBB even without inflammation?
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Fluconazole
Used for coccidioidal meningitis and cryptococcal meningitis. |
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What antifungal raises terfenidine ans astemizole levels that can decrease cardiac conduction, prolonging the QT interval and potentially causing fatal ventricular tachycardia TORSADE DE POINTES?
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KETOconazole
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What antifungal causes endocrinological disorders due to inhibition of steroid synthesis, such as decrease libido, gynecomasta, galactorrhea, and STILL BIRTHS.
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KETOconazole
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What antifungal is the DOC for oral candidiasis (moniliasis), thrush, and denture stomatitis?
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Nystatin
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What antifungal is givel orally but leaves a terrible foul taste for 7-10 days and it too toxic to be given systemic?
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Nystatin
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What is the MOA for Griseofulvin?
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Inhibits mitosis by disrupting spindle formation (microtubules)
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What is the clinical use of Griseofulvin?
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ONLY for tx againts Microsporum, Epidermophyton, and Trichophyton - systemic tx of skin, hair, and nail inf.
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What is the MOA of Echinocandins> "-fungin"
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Inhibit fungal-specific enzyme glucan synthese, which is req for the synthesis of the fungal cell wall component namely beta 1,3 D glucan.
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Which antifungal is DOC for oral tx of onychomycosis and tinea capitis?
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Turbanifine
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What is the MOA of Turbanifine?
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inhibition of squalene metabolism
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