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21 Cards in this Set
- Front
- Back
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GI, H/A, reversible renal dysfunction due to crystalline nephropathy
other: phlebitis, inflammation rare: tremors, hallucinations, seizures, coma |
Acyclovir (Zovirax)
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similar to acyclovir with more hallucinations, confusion, nephrotoxicity
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Valacyclovir (Valtrex)
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anorexia, nausea, pheripheral edema
elderly: CNS nervousness, anxiety, insomnia, lethargy, difficulty concentrating, lightheadedness |
Amantadine (Symmetrel)
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teratogenic
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Amantadine (Symmetrel)
Rimantadine (Flumadine) Ribavirin (Copegus, Rebetol) |
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nasal and throat discomfort, bronchospasm
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Zanamivir (Relenza)
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potentially fatal syndrome of lactic acidosis w/hepatic steatosis due to mitochondrial toxicity
also: fat redistribution and hyperlipidemia |
NRTIs
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anemia, neutropenia, N/V, H/A, fatigue, confusion, malaise, myophaty, hepatitis, hyperpigmentation of oral mucosa and nail beds
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Zidovudine (Retrovir, ZDV or AZT)
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severe hypersensitivity; usually w/ fever, resp and GI symptoms, malaise, rash
may be fatal |
Ziagan (Abacavir)
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rash that can be severe
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NNRTIs
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vivid dreams, nightmares, hallucinations
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Efavirenz (Sustiva)
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severe hepatotoxicity, hepatic failure that can lead to death
esp w/ increased transaminase or HBV or HCV or PEP |
Nevirapine (Viramune)
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GI distress, increased bleeding in hemophiliacs, hyperglycemia, insulin resistance, hyperlipidemia, CAD
syndrome of lipodystrophy: fat wasting, reaccumulation, redistribution |
Protease Inhibitors
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hepatotoxic
DDI common and can be severe intense GI distress is most problematic |
Ritonavir (Norvir)
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LOTS
bone marrow suppression, fatigue, depression, anxiety, psychosis, alopecia, hypo & hyperthyroidism, tinnitus, reversible hearing loss, auto-antibody, retinopathy, cardiotoxicity |
Interferons
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hemolytic anemia
w/ interferons: more cough, pruritis, rash |
Ribavirin (Copegus, Rebetol)
also teratogenic |
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pretreat with APAP, ASA, Benedryl, hydrocortisone to decrease SE
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amphotericin B
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fever, chills, rigor, nausea, myalgia, athralgia
dose-limiting: nephrotoxicity dose-dependent azotemia |
amphotericin B
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GI distress, rash, anaphylaxis, hepatic necrosis
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Flucanozole (Diflucan)
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dose-related nausea, abd discomfort, rash, serious hepatic toxicity, hypokalemia, HTN, CHF
decreased contraceptive effect |
Itracanazole (Sporonox)
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transient visual disturbances, blurred vision, photophobia, altered color perception, rash, hallucinations
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Voriconazole (Vfend)
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H/A, GI: diarrhea, dyspepsia, abd pain,
taste disturbance uticaria anaphylaxis, pancytopenia, severe neutropenia |
Terbinafine (Lamisil)
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