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14 Cards in this Set
- Front
- Back
- 3rd side (hint)
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Which of the muscarinic receptors are found on CNS neurons?
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all of them... but focus on M1, M4, and M5
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None
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Which muscarinic receptors are found on the postganglionic sympathetic receptors?
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M1 (thermoregulation - sweat glands)
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None
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Which muscarinic receptors are found on endocrine glands?
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M3
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None
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which 2 muscarinic receptors types are found on vascular endothelium?
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M5/M3
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None
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which muscarinic receptors are found on vagal nerve endings?
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M4
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Which muscarinic receptors are found on myocardium?
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M2
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Which muscarinic receptors are found in the GI and the genitourinial systems?
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M3
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What happens as a result of ligand binding on an M1,M3, M5, or ∂1 receptor?
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PLC --> IP3 and DAG formation --> increased intracellular Ca
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None
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What happens as a result of ligand binding on an M2 and M4 receptor?
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openining of K channels and inhibition of adenylyl cyclase --> decrease in cAMP
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None
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What happens as a result of ligand binding on a nicotinic receptor?
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opening of Na, k channels --> depolarization
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What happens as a result of ligand binding on an ∂2, D2, D3, D4 receptor?
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inhibition of adenylyl cyclase --> decrease in intracellular Ca+
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None
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What happens as a result of ligand binding on an D1, D5, ß2, ß3 receptor?
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stimulation of adenylyl cyclase and increased cAMP
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None
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where do you find ∂2 receptors?
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presynaptic adrenergic nerve terminals and platelet aggregation
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where do you find ∂1 receptors?
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postsynaptic effector cells, especially smooth muscle
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