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48 Cards in this Set
- Front
- Back
- 3rd side (hint)
Match the following catagories of drugs with their mneumonic :
(a) Ganglion blocker & AchE regenerator, Ach-Inhibitor, Anticholinergic Drugs, Cholinergic Drugs… (b) MeTH-Pee, MEN PeePeePEE, Piss BOAT, PBs oN MAC |
Ganglion blocker & AchE regenerator: MeTH Pee,
Ach-Inhibitor: MEN PeePeePee, Anticholinergic Drugs: Piss BOAT, Cholinergic Drugs: PBs oN MAC… |
None
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Name the 4-catagories of cholinergic drugs
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(1) Cholinomimetics
(2) Indirect Cholinergic Agonist (AchE Inhibitor) (3) Anticholinergic (4) Ganglion Blocker & AchE regenerator |
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Name the 6 cholinergic drugs. (hint?)
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pilocarpine, behtanechol, nicotine, methacholine, Ach, and carbamylcholine
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( PBs on MAC)
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Name the 3 Ganglion Blockers and the 1-AchE-Regenerator. (hint?)
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Ganglion Blockers: Mecamylamine, Trimethaphan, Hexamethonium… AchE-Regenerator: Pralidoxime
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MeTH-Pee
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Name the 8 Anticholinergic drugs. (hint?)
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pancuronium, ipratropium, succinylcholine, scopolamine, benztropine, oxybutynin, atropine, tropicamide.
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(Hint: PISS BOAT)
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which 2 of the cholinergics are direct M agonist?
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Bethanechol and Pilocarpine
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Which 3 of the the cholinergics have both M an N afinity? Which of the 3 has a M>N affinity?
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(1) methachoine, Ach, Carbamylcholine…(2) methacholine is M>N
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(hint: MAC)
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Name the 6 AchE-Inhibitors. (hint?)
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malathion, edrophonium, Neostigmine, physostigmine, pyrodostigmine, Parathion
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MEN PeePeePee
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Which of the cholinergics causes desensitization after prolonged use?
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Nicotine
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Which 3 of the cholinergics is potent at GI, GU and eye? Which of these two is not so potent on CV?
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Bethanechol, Pilocarpine, (Carbamylcholine)… Bethanecol is not so potent on CV
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None
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Which of the cholinergics is potent at the CV and used to diagnose bronchial hypersensitivity?
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Methacholine
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(1) Which 3 of the cholinergics is used to treat Glaucoma? (Hint?)
(2) which one of these is especially for chronic glaucoma/acute angle closure? |
(1) Carbamylcholine, Ach, Pilocarpine …
(NOTE: Bethanecol also has an effect on the MAch-eye) (2) :Pilocarpine |
(hint: Baseball CAP)
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Which of the cholinergics is used to Tx dry mouth and Sjøgren's syndrome?
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Pilocarpine
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Which of the cholinergics is used for post operative GI and for non-obstructive urinary retention?
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Bethanechol
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Of the 8 Anticholinergics, which are not M antagonists? Atropine, succinylcholine, ipratropium, tropicamide, pancuronium, scopolamine, oxybutynin, benztropine.
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Pancuronium and succinylcholine... they are Nicotinic antagonists
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They should be at the back of the bus
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Match the following nicotinic neuromuscular and neuronal receptor with (alpha, gamma, alpha, beta, delta… or alpha, beta, alpha, beta beta)
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neuromuscular: alpha, gamma, alpha, beta, delta... and neuronal receptor: alpha, beta, alpha, beta beta)
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Which cholinergic is short acting? And which is long lasting?
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Ach: short… Long=Bethanecol
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Cholinergic agonists are dose dependent: what are the low/high does effects of cholinergic agonist on the vasculature: constriction vs. dilation?
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Cholinergic agonist: low dose = dilation… high dose=constriction of BV
This makes sense if you consider that at lower dose M parasympathetice predominates... as opposed to at high dose it's mixed sympathetic and parasympathetic |
None
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What is the adverse effect of cholinergic agonist on atrial rhythm?
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ADR of cholinergic agonists: among others is atrial tachyarrhythmias (especially in hyperthyroid patients)...
Others are expected: Asthma Cardiac ischemia (due to low HR and low BP Peptic ulcer (due to enhanched secretion) Abdominal cramping |
None
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What can be used to treat organophasphate poisoining? What is the time consideration?
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Pralidoxine can be used to attach the phosphate, but it must be used before the aging has occurred
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What effect on the BP can Indirect cholinergic agonist have? Why?
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small decrease in BP due to opposing pregangionic symp and para effects
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What is seen in skeletal muscle with indirect cholinergic agonists?
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increased contractility, fasciculation, paralysis
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What effect do direct cholinergic antagonist have on the CNS?
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sedation, reduced Parkinsonian rigidity
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What is the effect of Atropine on HR as dose is increased?
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low=decrease HR… med =small increase… high high increase in HR
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(1) Which type of drug causes pupil dilation, but must be used with care because it can cause acute angle closure glaucoma in predisposed individuals
(2) Which drug in this class would be a good choice for people with glaucoma? why? |
(1) Anticholinergics are used to dilate the eye, but can cause acute angle closure glaucoma in predisposed patients.
(2) Tropicamide is short acting |
None
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Which anticholinergic drug can be used for Athma and COPD?
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Ipratropium
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None
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What drug can be used for overactive bladder, paraplegia and enuresis?
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Oxybutynin
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What drug can be used for actue treatment of bradycardia?
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atropine
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What drug can be used for Parkinson's disease?
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Benztropine
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What drug can be used for motion sickness
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scopolamine
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what drug can be used for acute AV heart block?
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atropine
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what drug can be used for organophosphate poisoning?
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large doses of atropine... also: pralodoxine to regenerate AchE, and pyridostigmine (which is an AchE inhibitor, but can be used as a prophylaxis.)
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None
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What drug can be used to diagnose Myasthenia Gravis? Which drugs can be used for tx of Myasthemia gravis? (hint?)
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Diag: edrophonium… Tx: pyridostigmine, neostigmine,
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hint: Pyne treat
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what drug can be used for paralytic ileus?
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neostigmine
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None
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what drug can be used for atonic bladder?
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neostigmine
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What drug can be used as a prophylaxis for organophosphate poisoning?
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pyridostigmine
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What drug can be used to regenerate enzymes in organophosphate poisoining?
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pralidoxine… large dose of atropine for poisoining
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What drug can be used for anticholinergic poisoining?
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physostigmine
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Which is faster, NAchR or MAchR… why?
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NAchR= ligand gated very fast… MAchR = G=protein slower
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What are the 3 types of Ach deactivation from fast to slow?
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Fastest: AchE (seconds) > Desensitization (min-hrs)> Down reg (hours -days)
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How does AcH open NAchR?
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(1) ligand gated non selective Na/K… (2) binding of 2 Ach moleules open channel --> EPSP
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What is Sarin Gas?
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Sarin: a nerve gas with indirect cholinergic agonist effects (organophosphate)
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What type of receptors are seen in muscarinic receptors?
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G coupled proteins
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T/F, both N and M receptors can undergo desensitization?
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TRUE
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Where are the two sites of activity for the Anticholinergics?
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M (antagonists) and Na channel R blockers
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T/F: Atropine works on all M receptors?
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TRUE
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What effect does Botulinum Toxin have on Ach release?
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Inhibition
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Name the two short acting anticholinergics
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Atropine and Tropicamide
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