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48 Cards in this Set

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  • Back
  • 3rd side (hint)
Match the following catagories of drugs with their mneumonic :
(a) Ganglion blocker & AchE regenerator,
Ach-Inhibitor,
Anticholinergic Drugs,
Cholinergic Drugs…

(b) MeTH-Pee,
MEN PeePeePEE,
Piss BOAT,
PBs oN MAC
Ganglion blocker & AchE regenerator: MeTH Pee,

Ach-Inhibitor: MEN PeePeePee,

Anticholinergic Drugs: Piss BOAT,

Cholinergic Drugs: PBs oN MAC…
None
Name the 4-catagories of cholinergic drugs
(1) Cholinomimetics
(2) Indirect Cholinergic Agonist (AchE Inhibitor)
(3) Anticholinergic
(4) Ganglion Blocker & AchE regenerator
Name the 6 cholinergic drugs. (hint?)
pilocarpine, behtanechol, nicotine, methacholine, Ach, and carbamylcholine
( PBs on MAC)
Name the 3 Ganglion Blockers and the 1-AchE-Regenerator. (hint?)
Ganglion Blockers: Mecamylamine, Trimethaphan, Hexamethonium… AchE-Regenerator: Pralidoxime
MeTH-Pee
Name the 8 Anticholinergic drugs. (hint?)
pancuronium, ipratropium, succinylcholine, scopolamine, benztropine, oxybutynin, atropine, tropicamide.
(Hint: PISS BOAT)
which 2 of the cholinergics are direct M agonist?
Bethanechol and Pilocarpine
Which 3 of the the cholinergics have both M an N afinity? Which of the 3 has a M>N affinity?
(1) methachoine, Ach, Carbamylcholine…(2) methacholine is M>N
(hint: MAC)
Name the 6 AchE-Inhibitors. (hint?)
malathion, edrophonium, Neostigmine, physostigmine, pyrodostigmine, Parathion
MEN PeePeePee
Which of the cholinergics causes desensitization after prolonged use?
Nicotine
Which 3 of the cholinergics is potent at GI, GU and eye? Which of these two is not so potent on CV?
Bethanechol, Pilocarpine, (Carbamylcholine)… Bethanecol is not so potent on CV
None
Which of the cholinergics is potent at the CV and used to diagnose bronchial hypersensitivity?
Methacholine
(1) Which 3 of the cholinergics is used to treat Glaucoma? (Hint?)

(2) which one of these is especially for chronic glaucoma/acute angle closure?
(1) Carbamylcholine, Ach, Pilocarpine …

(NOTE: Bethanecol also has an effect on the MAch-eye)

(2) :Pilocarpine
(hint: Baseball CAP)
Which of the cholinergics is used to Tx dry mouth and Sjøgren's syndrome?
Pilocarpine
Which of the cholinergics is used for post operative GI and for non-obstructive urinary retention?
Bethanechol
Of the 8 Anticholinergics, which are not M antagonists? Atropine, succinylcholine, ipratropium, tropicamide, pancuronium, scopolamine, oxybutynin, benztropine.
Pancuronium and succinylcholine... they are Nicotinic antagonists
They should be at the back of the bus
Match the following nicotinic neuromuscular and neuronal receptor with (alpha, gamma, alpha, beta, delta… or alpha, beta, alpha, beta beta)
neuromuscular: alpha, gamma, alpha, beta, delta... and neuronal receptor: alpha, beta, alpha, beta beta)
Which cholinergic is short acting? And which is long lasting?
Ach: short… Long=Bethanecol
Cholinergic agonists are dose dependent: what are the low/high does effects of cholinergic agonist on the vasculature: constriction vs. dilation?
Cholinergic agonist: low dose = dilation… high dose=constriction of BV

This makes sense if you consider that at lower dose M parasympathetice predominates... as opposed to at high dose it's mixed sympathetic and parasympathetic
None
What is the adverse effect of cholinergic agonist on atrial rhythm?
ADR of cholinergic agonists: among others is atrial tachyarrhythmias (especially in hyperthyroid patients)...

Others are expected:
Asthma
Cardiac ischemia (due to low HR and low BP
Peptic ulcer (due to enhanched secretion)
Abdominal cramping
None
What can be used to treat organophasphate poisoining? What is the time consideration?
Pralidoxine can be used to attach the phosphate, but it must be used before the aging has occurred
What effect on the BP can Indirect cholinergic agonist have? Why?
small decrease in BP due to opposing pregangionic symp and para effects
What is seen in skeletal muscle with indirect cholinergic agonists?
increased contractility, fasciculation, paralysis
What effect do direct cholinergic antagonist have on the CNS?
sedation, reduced Parkinsonian rigidity
What is the effect of Atropine on HR as dose is increased?
low=decrease HR… med =small increase… high high increase in HR
(1) Which type of drug causes pupil dilation, but must be used with care because it can cause acute angle closure glaucoma in predisposed individuals

(2) Which drug in this class would be a good choice for people with glaucoma? why?
(1) Anticholinergics are used to dilate the eye, but can cause acute angle closure glaucoma in predisposed patients.

(2) Tropicamide is short acting
None
Which anticholinergic drug can be used for Athma and COPD?
Ipratropium
None
What drug can be used for overactive bladder, paraplegia and enuresis?
Oxybutynin
What drug can be used for actue treatment of bradycardia?
atropine
What drug can be used for Parkinson's disease?
Benztropine
What drug can be used for motion sickness
scopolamine
what drug can be used for acute AV heart block?
atropine
what drug can be used for organophosphate poisoning?
large doses of atropine... also: pralodoxine to regenerate AchE, and pyridostigmine (which is an AchE inhibitor, but can be used as a prophylaxis.)
None
What drug can be used to diagnose Myasthenia Gravis? Which drugs can be used for tx of Myasthemia gravis? (hint?)
Diag: edrophonium… Tx: pyridostigmine, neostigmine,
hint: Pyne treat
what drug can be used for paralytic ileus?
neostigmine
None
what drug can be used for atonic bladder?
neostigmine
What drug can be used as a prophylaxis for organophosphate poisoning?
pyridostigmine
What drug can be used to regenerate enzymes in organophosphate poisoining?
pralidoxine… large dose of atropine for poisoining
What drug can be used for anticholinergic poisoining?
physostigmine
Which is faster, NAchR or MAchR… why?
NAchR= ligand gated very fast… MAchR = G=protein slower
What are the 3 types of Ach deactivation from fast to slow?
Fastest: AchE (seconds) > Desensitization (min-hrs)> Down reg (hours -days)
How does AcH open NAchR?
(1) ligand gated non selective Na/K… (2) binding of 2 Ach moleules open channel --> EPSP
What is Sarin Gas?
Sarin: a nerve gas with indirect cholinergic agonist effects (organophosphate)
What type of receptors are seen in muscarinic receptors?
G coupled proteins
T/F, both N and M receptors can undergo desensitization?
TRUE
Where are the two sites of activity for the Anticholinergics?
M (antagonists) and Na channel R blockers
T/F: Atropine works on all M receptors?
TRUE
What effect does Botulinum Toxin have on Ach release?
Inhibition
Name the two short acting anticholinergics
Atropine and Tropicamide