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10 Cards in this Set
- Front
- Back
- 3rd side (hint)
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Name the 3 Ganglion Blockers and the 1-AchE-Regenerator.
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Ganglion Blockers: Mecamylamine, Trimethaphan, Hexamethonium… AchE-Regenerator: Pralidoxime
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What is the receptor affinity of all ganglion blockers?
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Ach-Nicotinic antagonist
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Between ganglion blockers Mecamylamine, Hexmethonium, and Trimethaphan, which enters the brain? (hint?)
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Mecamylamine enters the brain
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HInt: "M"ental = brain
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For Mecamylamine, what is it's route of administration? What is its Tx? What are its ADRs?
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Mecamylamine Ganglion Blocker (N)... l: (1) ROA: GI better/oral… (2) Tx: lowers Nicotine cravings… use to be used for HTN… (3) combined sym and para blockade, postural hypotension; hypotensive actions can be accentuated by heat extremes, fever, infection, hemorrhage, anesthesia, surgery, excessive fluid losses, and use of diuretics, bethanechol, urinary alkalizers, ethanol. Hyperthermia in warm weather
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For Trimethaphan, what is it's route of administration? What is its Tx? What are its ADRs?
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Trimethaphan Ganglion Blocker (N) - blocks by blocking attached channe: (1) ROA: inactive orally, given parenternally… (2) Tx: HTN emergency, descending aortic aneurism… (3) ADR: orthostatic hypotension, hyperthermia in warm weather
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For Hexmethonium, what is it's route of administration? What is its Tx? What are its ADRs?
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Hexmethonium Ganglion Blocker (N): (1) ROA:?.. (2) use to be used for HTN… (3) orthostatic hypotension, hyperthermia in warm weather
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Between ganglion blockers Mecamylamine, Hexmethonium, and Trimethaphan, which is a combined para and sympathetic block?
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Hexamethonium and Mecamylamine both are combined
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What is Pradiloxime?
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regenerates AchE
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How does Pradiloxime regenerate AchE?
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Pradiloxime regenerates AchE by removing the phosphoryl group from the inhibited cholinesterase molecule, reactivating the enzyme and restoring the body's ability to metabolize acetylcholine
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Where does Pradiloxime work best? And what should be used with it? When should it be used?
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"Pradiloxime (1) works best at nicotinic receptors, NMJ and respiratory muscles (though relief of resp. depression is not significant). (2) Should be used with atropine to decrease M affect… (3) Works best before 24hrs
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