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10 Cards in this Set

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Name the 3 Ganglion Blockers and the 1-AchE-Regenerator.
Ganglion Blockers: Mecamylamine, Trimethaphan, Hexamethonium… AchE-Regenerator: Pralidoxime
What is the receptor affinity of all ganglion blockers?
Ach-Nicotinic antagonist
Between ganglion blockers Mecamylamine, Hexmethonium, and Trimethaphan, which enters the brain? (hint?)
Mecamylamine enters the brain
HInt: "M"ental = brain
For Mecamylamine, what is it's route of administration? What is its Tx? What are its ADRs?
Mecamylamine Ganglion Blocker (N)... l: (1) ROA: GI better/oral… (2) Tx: lowers Nicotine cravings… use to be used for HTN… (3) combined sym and para blockade, postural hypotension; hypotensive actions can be accentuated by heat extremes, fever, infection, hemorrhage, anesthesia, surgery, excessive fluid losses, and use of diuretics, bethanechol, urinary alkalizers, ethanol. Hyperthermia in warm weather
For Trimethaphan, what is it's route of administration? What is its Tx? What are its ADRs?
Trimethaphan Ganglion Blocker (N) - blocks by blocking attached channe: (1) ROA: inactive orally, given parenternally… (2) Tx: HTN emergency, descending aortic aneurism… (3) ADR: orthostatic hypotension, hyperthermia in warm weather
For Hexmethonium, what is it's route of administration? What is its Tx? What are its ADRs?
Hexmethonium Ganglion Blocker (N): (1) ROA:?.. (2) use to be used for HTN… (3) orthostatic hypotension, hyperthermia in warm weather
Between ganglion blockers Mecamylamine, Hexmethonium, and Trimethaphan, which is a combined para and sympathetic block?
Hexamethonium and Mecamylamine both are combined
What is Pradiloxime?
regenerates AchE
How does Pradiloxime regenerate AchE?
Pradiloxime regenerates AchE by removing the phosphoryl group from the inhibited cholinesterase molecule, reactivating the enzyme and restoring the body's ability to metabolize acetylcholine
Where does Pradiloxime work best? And what should be used with it? When should it be used?
"Pradiloxime (1) works best at nicotinic receptors, NMJ and respiratory muscles (though relief of resp. depression is not significant). (2) Should be used with atropine to decrease M affect… (3) Works best before 24hrs