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17 Cards in this Set

  • Front
  • Back
  • 3rd side (hint)
Name the 6 cholinergic drugs.

(Hint?)
Ach, Nicotine, behtanechol, methacholine, pilocarpine, and carbamylcholine
(Hint: watch PBs oN MAC)
which 2 of the cholinergics are direct M agonist? (hint?)
Bethanechol and Pilocarpine... these direct M agonist act on M only...

thus they are also more like to decrease BP because they don't act on ganglionic (N... sympathetic ganglions)
(hint: which would be more likely to lower BP, in other words, where do these agonist act????)
Which 3 of the the cholinergics have both M an N afinity? Which of the 3 has a M>N affinity?
(1) methachoine, Ach, Carbamylcholine…(2) methacholine is M>N
None
Which of the cholinergics is potent at the CV and used to diagnose bronchial hypersensitivity?
Methacholine
For Ach, what is its receptor affinity?

Based on Systemic Dose (low, high, very high), where does Ach have a greater effect - at NMJ, para and symp?

Administration/duration?Tx?
Ach:
(1) Affinity: Direct MN agonist…

(2) Location effect based on dose of:
Ach: @Low doses- parasympathetic

Ach: @ high doses-sympathetic + parasympathetic

Ach: @ very high doses- NMJ…

(3) Admin: Very short acting IV…

(4) Tx: antiglaucoma, mitotic
None
Which of the cholinergics causes desensitization after prolonged use?
Nicotine
(1) Which 3 of the cholinergics is used to treat Glaucoma?
(2) Which is most used for chronic Glaucoma?
(3) Which is especially useful for narrow-angle closure?
(4) Which is more helpful with acute angle closure? (hint: ?)

(5) Which cholinergic can be used to Tx Tourett's?
(1) Glaucoma: Carbamylcholine, Ach, Pilocarpine… (Bethanecol does have an effect on the M-AchR of the eye)
(2) Chronic Glaucoma: Pilocarpine
(3) Acute angle closure: Pilocarpine (4) Narrow angle closure: Carbamylcholine

(2) Tourette's: Nicotine
Baseball CAP
For Nicotine, what is its receptor affinity? Where is it effective? Administration?Tx?
Nicotine: (1) Affinity: N agonist, … (2) Location: Autonomic ganglia stimulant (and desensitizer after prolonged use)… alkaloid disperse in entire body, incl CNS (3) Admin: Oral, transdermal, aerosol (4) Tx: quit smoking, torette's
None
Which 3 of the cholinergics is potent at GI, GU, (and eye)?

Which of these two is not so potent on CV? (Hint: ?)
Carbamylcholine, Bethanechol, and Pilocarpine…

Bethanecol is not so potent on CV
Bowel movement's (CaCa) and Peeing
(1) What is the ADR for Nicotine?

(2) Which cholinergic agonist has a effect on the NaChR?

(3) Of the direct cholinergic agoinsts, which is very short acting and very long acting?

(4) Which direct cholinergic agonist is inhaled?
(1) Nicotine ADRs: tachycardia, bradycardia, stim of barorecptors, release of EPI

(2) Carbamylcholine

(3) very short: Ach... very long: bethanecol

(4) Methacholine (used to test for bronchial airway hyperactivity)
None
Which of the cholinergics is used to Tx dry mouth and Sjøgren's syndrome?
Pilocarpine
For Bethanechol, what is its receptor affinity? Where is it effective? Administration?Tx?
Bethanechol: (1) Affinity: Direct M agonist… (2) Location: V. potent at GI, GU ( and eye). Not much at CV… (3) Admin: Longer lasting orally absorbed… (4) Tx: postop gastric atony, nonobstructive urinary retention
None
For Methacholine, what is its receptor affinity? Where is it effective? Administration?Tx?
Methacholine (1) Affinity: M>N agoinist… (2) Location: V. potent at CV... (3) Admin: inhaled... (4) Tx: diagnosis of hyperreactive bronchial airways
Which Cholinergic drug has a drug interactions with β-blockers that results in the Cholinergic's prolong or exaggerate effects?
Methacholine: interactions with β-blockers that results in the Methacholine's prolong or exaggerate effects.
hint: if you flip the ß on its side it looks like an "M"
Which of the cholinergics is used for post operative GI and for non-obstructive urinary retention?
Bethanechol
For Pilocarine, what is its receptor affinity? Where is it effective? Administration?Tx?
Pilocarine: (1) Affinity: Direct M agonist… (2) Location:V. potent at GI, GU, eye… (3) Admin: Direct ophthalmologic preparations and oral (4) Tx: Dry mouth, Sjogren’s syndrome, chronic glaucoma, acute narrow-angle closure
For Carbamylcholine, what is its receptor affinity? Where is it effective? Tx?
Carbamylcholine: (1) Affinity: Direct M&N agonist... (2) Location: V. Potent at GI, GU, NaChR (3) Admin: none (4) Tx: glaucoma, miotic, ocular HTN