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17 Cards in this Set
- Front
- Back
- 3rd side (hint)
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Name the 6 cholinergic drugs.
(Hint?) |
Ach, Nicotine, behtanechol, methacholine, pilocarpine, and carbamylcholine
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(Hint: watch PBs oN MAC)
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which 2 of the cholinergics are direct M agonist? (hint?)
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Bethanechol and Pilocarpine... these direct M agonist act on M only...
thus they are also more like to decrease BP because they don't act on ganglionic (N... sympathetic ganglions) |
(hint: which would be more likely to lower BP, in other words, where do these agonist act????)
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Which 3 of the the cholinergics have both M an N afinity? Which of the 3 has a M>N affinity?
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(1) methachoine, Ach, Carbamylcholine…(2) methacholine is M>N
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None
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Which of the cholinergics is potent at the CV and used to diagnose bronchial hypersensitivity?
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Methacholine
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For Ach, what is its receptor affinity?
Based on Systemic Dose (low, high, very high), where does Ach have a greater effect - at NMJ, para and symp? Administration/duration?Tx? |
Ach:
(1) Affinity: Direct MN agonist… (2) Location effect based on dose of: Ach: @Low doses- parasympathetic Ach: @ high doses-sympathetic + parasympathetic Ach: @ very high doses- NMJ… (3) Admin: Very short acting IV… (4) Tx: antiglaucoma, mitotic |
None
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Which of the cholinergics causes desensitization after prolonged use?
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Nicotine
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(1) Which 3 of the cholinergics is used to treat Glaucoma?
(2) Which is most used for chronic Glaucoma? (3) Which is especially useful for narrow-angle closure? (4) Which is more helpful with acute angle closure? (hint: ?) (5) Which cholinergic can be used to Tx Tourett's? |
(1) Glaucoma: Carbamylcholine, Ach, Pilocarpine… (Bethanecol does have an effect on the M-AchR of the eye)
(2) Chronic Glaucoma: Pilocarpine (3) Acute angle closure: Pilocarpine (4) Narrow angle closure: Carbamylcholine (2) Tourette's: Nicotine |
Baseball CAP
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For Nicotine, what is its receptor affinity? Where is it effective? Administration?Tx?
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Nicotine: (1) Affinity: N agonist, … (2) Location: Autonomic ganglia stimulant (and desensitizer after prolonged use)… alkaloid disperse in entire body, incl CNS (3) Admin: Oral, transdermal, aerosol (4) Tx: quit smoking, torette's
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None
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Which 3 of the cholinergics is potent at GI, GU, (and eye)?
Which of these two is not so potent on CV? (Hint: ?) |
Carbamylcholine, Bethanechol, and Pilocarpine…
Bethanecol is not so potent on CV |
Bowel movement's (CaCa) and Peeing
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(1) What is the ADR for Nicotine?
(2) Which cholinergic agonist has a effect on the NaChR? (3) Of the direct cholinergic agoinsts, which is very short acting and very long acting? (4) Which direct cholinergic agonist is inhaled? |
(1) Nicotine ADRs: tachycardia, bradycardia, stim of barorecptors, release of EPI
(2) Carbamylcholine (3) very short: Ach... very long: bethanecol (4) Methacholine (used to test for bronchial airway hyperactivity) |
None
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Which of the cholinergics is used to Tx dry mouth and Sjøgren's syndrome?
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Pilocarpine
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For Bethanechol, what is its receptor affinity? Where is it effective? Administration?Tx?
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Bethanechol: (1) Affinity: Direct M agonist… (2) Location: V. potent at GI, GU ( and eye). Not much at CV… (3) Admin: Longer lasting orally absorbed… (4) Tx: postop gastric atony, nonobstructive urinary retention
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None
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For Methacholine, what is its receptor affinity? Where is it effective? Administration?Tx?
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Methacholine (1) Affinity: M>N agoinist… (2) Location: V. potent at CV... (3) Admin: inhaled... (4) Tx: diagnosis of hyperreactive bronchial airways
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Which Cholinergic drug has a drug interactions with β-blockers that results in the Cholinergic's prolong or exaggerate effects?
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Methacholine: interactions with β-blockers that results in the Methacholine's prolong or exaggerate effects.
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hint: if you flip the ß on its side it looks like an "M"
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Which of the cholinergics is used for post operative GI and for non-obstructive urinary retention?
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Bethanechol
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For Pilocarine, what is its receptor affinity? Where is it effective? Administration?Tx?
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Pilocarine: (1) Affinity: Direct M agonist… (2) Location:V. potent at GI, GU, eye… (3) Admin: Direct ophthalmologic preparations and oral (4) Tx: Dry mouth, Sjogren’s syndrome, chronic glaucoma, acute narrow-angle closure
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For Carbamylcholine, what is its receptor affinity? Where is it effective? Tx?
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Carbamylcholine: (1) Affinity: Direct M&N agonist... (2) Location: V. Potent at GI, GU, NaChR (3) Admin: none (4) Tx: glaucoma, miotic, ocular HTN
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