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8 Cards in this Set
- Front
- Back
- 3rd side (hint)
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Name the 6 AchE-Inhibitors. (Hint?)
Which ones are 4° amines, Cabamate Ester, and organophosphates? |
4° amines: edrophonium
Cabamate Ester: Neostigmine, physostigmine, pyrodostigmine Organophosphates: malathion, Parathion (sarin gas too) |
MEN PeePeePee
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For Neostigmine, what class of AchE-Inhibitor is it? Is it revesible? Route of admin? Duration? Tx?
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Neostigmine: (1) Class: Carbamate ester … (2)Reversible… (3) ROA: oral / parenternal… (4) Duration: minutes to hours… (5) Tx: Myasthenia gravis, paralytic lleus, atonic bladder
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For Physostigmine, what class of AchE-Inhibitor is it? Is it revesible? Route of admin? Duration? Tx?
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Physostigmine (1) Class: Carbamate ester… (2)Reversible… (3) ROA: parenternal … (4) Duration: min to hrs… (5) Tx:anticholinergic poisoning, glaucoma
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For Pyrodostigmine, what class of AchE-Inhibitor is it? Is it revesible? Route of admin? Duration? Tx?
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Pyrodostigmine: (1) Class:Carbamate ester… (2)Reversible… (3) ROA: oral/parenternal - enters the BRAIN … (4) Duration: Hrs … (5) Tx: Myasthenia gravis, prophylaxis for organophosphate poisoning
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What are the ADRs of Pyridostigmine?
Which Indirect cholinergic-AchE inhibitor is used for Anticholinergic poisoining? |
Pyridostigmine ADRs: Bradycardia, bronchospasm, ↑secretions, miosis… NOTE: it enters the BRAIN
(2) Physostigmine is used for Anticholinergic poisoining? |
None
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For Edrophonium, what class of AchE-Inhibitor is it? Is it revesible? Route of admin? Duration? Tx?
(6) Which AchE inhibitor enters the Brain? |
Edrophonium: (1) Class: Amine … (2)Reversible… (3) ROA: parenternal … (4) Duration: short acting minutes… (5) Tx: Myasthenia gravis diagnostic, ileus, arrhythmias
(6) Pyridostigmine |
None
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For Malathion, what class of AchE-Inhibitor is it? Is it revesible? Route of admin? Duration? Tx?
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Malathion: (1) Class: organophosphate … (2)Irreversible… (3) ROA:Nerve gas … (4) Duration: Long acting toxin, lipid soluble, activated after absorption S→O replacement… (5) Tx: ectoparasites (ie. Lice)
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For Parathion, what class of AchE-Inhibitor is it? Is it revesible? Route of admin? Duration? Tx?
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Parathion: (1) Class: organophosphate … (2)Irreversible… (3) ROA: Nerve gas … (4) Duration: - Long acting toxin, lipid soluble, activated after absorption S→O replacement … (5) Tx: none
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