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8 Cards in this Set

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Name the 6 AchE-Inhibitors. (Hint?)

Which ones are 4° amines, Cabamate Ester, and organophosphates?
4° amines: edrophonium

Cabamate Ester: Neostigmine, physostigmine, pyrodostigmine

Organophosphates: malathion, Parathion (sarin gas too)
MEN PeePeePee
For Neostigmine, what class of AchE-Inhibitor is it? Is it revesible? Route of admin? Duration? Tx?
Neostigmine: (1) Class: Carbamate ester … (2)Reversible… (3) ROA: oral / parenternal… (4) Duration: minutes to hours… (5) Tx: Myasthenia gravis, paralytic lleus, atonic bladder
For Physostigmine, what class of AchE-Inhibitor is it? Is it revesible? Route of admin? Duration? Tx?
Physostigmine (1) Class: Carbamate ester… (2)Reversible… (3) ROA: parenternal … (4) Duration: min to hrs… (5) Tx:anticholinergic poisoning, glaucoma
For Pyrodostigmine, what class of AchE-Inhibitor is it? Is it revesible? Route of admin? Duration? Tx?
Pyrodostigmine: (1) Class:Carbamate ester… (2)Reversible… (3) ROA: oral/parenternal - enters the BRAIN … (4) Duration: Hrs … (5) Tx: Myasthenia gravis, prophylaxis for organophosphate poisoning
What are the ADRs of Pyridostigmine?

Which Indirect cholinergic-AchE inhibitor is used for Anticholinergic poisoining?
Pyridostigmine ADRs: Bradycardia, bronchospasm, ↑secretions, miosis… NOTE: it enters the BRAIN

(2) Physostigmine is used for Anticholinergic poisoining?
None
For Edrophonium, what class of AchE-Inhibitor is it? Is it revesible? Route of admin? Duration? Tx?

(6) Which AchE inhibitor enters the Brain?
Edrophonium: (1) Class: Amine … (2)Reversible… (3) ROA: parenternal … (4) Duration: short acting minutes… (5) Tx: Myasthenia gravis diagnostic, ileus, arrhythmias

(6) Pyridostigmine
None
For Malathion, what class of AchE-Inhibitor is it? Is it revesible? Route of admin? Duration? Tx?
Malathion: (1) Class: organophosphate … (2)Irreversible… (3) ROA:Nerve gas … (4) Duration: Long acting toxin, lipid soluble, activated after absorption S→O replacement… (5) Tx: ectoparasites (ie. Lice)
For Parathion, what class of AchE-Inhibitor is it? Is it revesible? Route of admin? Duration? Tx?
Parathion: (1) Class: organophosphate … (2)Irreversible… (3) ROA: Nerve gas … (4) Duration: - Long acting toxin, lipid soluble, activated after absorption S→O replacement … (5) Tx: none