Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
42 Cards in this Set
- Front
- Back
|
what are the 4 main classes of ART?
|
Fusion Inhibitors
NRTI's NNRTI's PI's |
|
|
what is the MOA of Fuzeon?
|
to prevent GP120 from binding to CD4 cells
90mg SC BID. refrigerate. |
|
|
what are some AE of fuzeon?
|
local site reactions, induration, nodules or cysts, itching, redness, bruising, pain
|
|
|
what is the only NRTI that does not require renal dose adjusting?
|
abacavir ABC
|
|
|
what is the MOA of NRTI's?
|
to inhibit RT by competatively incorporating themselves into DNA thereby causing chain termination
|
|
|
what is truvada?
|
an NRTI combo:
emtriva + Viread 1 tablet QD |
|
|
what major side effect does DDI cause?
|
N/V/D stomach pain
|
|
|
what two NRTI's are associated with pancreatitis??
|
didanosine DDI and stavudine D14
|
|
|
which ART's are associated with peripheral neuropathy?
|
Didanosine: DDI
Stavudine: D14 Hydroxyurea Isoniazide |
|
|
how can you prevent peripheral neuropathies in HIV patients?
|
give vitamin B6 complexes
|
|
|
lactic acidosis w/ hepatic steatosis, SOB, fatigue, N/V are especially associate with which NRTI's?
|
Didanosine DDI
Stavudine D14 |
|
|
which NRTI's esp. cause Lipoatrophy?
|
Didanosine: DDI
Stavudine: D14 |
|
|
which NRTI is contraindicated in p who have extremely elevated TC and TRG's?
|
stavudine: D14
|
|
|
which NRTI causes anemia and neutropenia?
|
zidovudine
|
|
|
which NRTI causes a hypersensitivity reaction?
|
abacavir
|
|
|
what is the MOA of NNRTI's?
|
to inhibit RT by non competitively attaching to and inhibiting the enzyme itself
|
|
|
name two NNRTI's?
|
nevirapine NVP
Efavirenz: sustiva: EFV |
|
|
what is the only ART with CNS toxicity?
|
sustiva: EFV
|
|
|
which NNRTI has the greatest potential for liver toxicity?
|
nevirapine
|
|
|
which NNRIT most commonly causes a rash?
|
nevirapine
|
|
|
what is the MOA of Protease Inhibitors?
|
prevent HIV from being successfully assembled and released from infected CD4 cells
|
|
|
name 4 ART's that are inducers of drug metabolism
|
amprenavir, efavirenz, tipranavir, nevirapine
|
|
|
name a class of ART's that inhibit drug metabolism?
|
PI's
|
|
|
which ART is a potent inhibitor of the CYP450 3A and is used to reduce clearance of other PI's?
|
Ritonavir
|
|
|
which Two ART's are absolutely contraindicated to use together because they antagonize each other's metabolism?
|
zidovudine and stavudine D14
|
|
|
which natural OTC supplement/depression treatment is contraindicated in the use of PI's and NRTI's because it is a powerful inducer of metab?
|
st. john's wart
|
|
|
what is the preferred NRTI based regimen according to our text?
|
efavirenz: EFV
lamivudine: 3TC zidovudine:AZT |
|
|
what is the preferred PI based regimen according to our text?
|
Ritonivir
lamivudine zidovudine |
|
|
which ART do you associate the most with diarrhea?
|
nelfinavir
|
|
|
which PI's are associated with diarrhea?
|
Nelfinavir
Saquinavir Kaletra |
|
|
which class of ART's causes lipodystrophy: symptoms of increased abdominal girth, breast size and/or buffalo hump?
|
PI's
|
|
|
which ART is the only "cholesterol friendly" ?
|
atazanavir
|
|
|
which class of ART's is notorious for increasing the cholesterol?
|
PI's esp TRG Ritonivir containing regimens
|
|
|
which class is known to increase GLUCOSE?
|
PI's especially indinavir
|
|
|
which PI's causes an increase in bilirubin?
|
indinavir
atazanavir |
|
|
which ART causes numbness around the mouth?
|
ritonivir
|
|
|
which PI's cause rash?
|
F-amprenavir
Amprenavir Tipranavir |
|
|
which ART is contraindicated to use with didanosine?
|
tenofovir.
must decrease DDI dose. if < 60kg: 200mg if > 60kg: 250mg |
|
|
which two drugs need to be separated by two hours if given together if using the EC formulation?
|
didanosine decreases tipranavir levels
|
|
|
when should didanosine be taken in relation to meal time?
|
30 minutes before or 2 hours after except with tenofovir
|
|
|
when should efavirenz be taken in relation to meal time?
|
on an empty stomach
|
|
|
which ART, when taken with food increases the bioavailabilty ?
|
atazanavir
|
