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42 Cards in this Set

  • Front
  • Back
what are the 4 main classes of ART?
Fusion Inhibitors
NRTI's
NNRTI's
PI's
what is the MOA of Fuzeon?
to prevent GP120 from binding to CD4 cells

90mg SC BID. refrigerate.
what are some AE of fuzeon?
local site reactions, induration, nodules or cysts, itching, redness, bruising, pain
what is the only NRTI that does not require renal dose adjusting?
abacavir ABC
what is the MOA of NRTI's?
to inhibit RT by competatively incorporating themselves into DNA thereby causing chain termination
what is truvada?
an NRTI combo:
emtriva + Viread
1 tablet QD
what major side effect does DDI cause?
N/V/D stomach pain
what two NRTI's are associated with pancreatitis??
didanosine DDI and stavudine D14
which ART's are associated with peripheral neuropathy?
Didanosine: DDI
Stavudine: D14
Hydroxyurea
Isoniazide
how can you prevent peripheral neuropathies in HIV patients?
give vitamin B6 complexes
lactic acidosis w/ hepatic steatosis, SOB, fatigue, N/V are especially associate with which NRTI's?
Didanosine DDI
Stavudine D14
which NRTI's esp. cause Lipoatrophy?
Didanosine: DDI
Stavudine: D14
which NRTI is contraindicated in p who have extremely elevated TC and TRG's?
stavudine: D14
which NRTI causes anemia and neutropenia?
zidovudine
which NRTI causes a hypersensitivity reaction?
abacavir
what is the MOA of NNRTI's?
to inhibit RT by non competitively attaching to and inhibiting the enzyme itself
name two NNRTI's?
nevirapine NVP
Efavirenz: sustiva: EFV
what is the only ART with CNS toxicity?
sustiva: EFV
which NNRTI has the greatest potential for liver toxicity?
nevirapine
which NNRIT most commonly causes a rash?
nevirapine
what is the MOA of Protease Inhibitors?
prevent HIV from being successfully assembled and released from infected CD4 cells
name 4 ART's that are inducers of drug metabolism
amprenavir, efavirenz, tipranavir, nevirapine
name a class of ART's that inhibit drug metabolism?
PI's
which ART is a potent inhibitor of the CYP450 3A and is used to reduce clearance of other PI's?
Ritonavir
which Two ART's are absolutely contraindicated to use together because they antagonize each other's metabolism?
zidovudine and stavudine D14
which natural OTC supplement/depression treatment is contraindicated in the use of PI's and NRTI's because it is a powerful inducer of metab?
st. john's wart
what is the preferred NRTI based regimen according to our text?
efavirenz: EFV
lamivudine: 3TC
zidovudine:AZT
what is the preferred PI based regimen according to our text?
Ritonivir
lamivudine
zidovudine
which ART do you associate the most with diarrhea?
nelfinavir
which PI's are associated with diarrhea?
Nelfinavir
Saquinavir
Kaletra
which class of ART's causes lipodystrophy: symptoms of increased abdominal girth, breast size and/or buffalo hump?
PI's
which ART is the only "cholesterol friendly" ?
atazanavir
which class of ART's is notorious for increasing the cholesterol?
PI's esp TRG Ritonivir containing regimens
which class is known to increase GLUCOSE?
PI's especially indinavir
which PI's causes an increase in bilirubin?
indinavir
atazanavir
which ART causes numbness around the mouth?
ritonivir
which PI's cause rash?
F-amprenavir
Amprenavir
Tipranavir
which ART is contraindicated to use with didanosine?
tenofovir.
must decrease DDI dose.
if < 60kg: 200mg
if > 60kg: 250mg
which two drugs need to be separated by two hours if given together if using the EC formulation?
didanosine decreases tipranavir levels
when should didanosine be taken in relation to meal time?
30 minutes before or 2 hours after except with tenofovir
when should efavirenz be taken in relation to meal time?
on an empty stomach
which ART, when taken with food increases the bioavailabilty ?
atazanavir