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12 Cards in this Set

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*inhalation for asthma

*ophthalmic for allergy

*nasal for allergy

*oral for food allergy
Cromolyn sodium
pharm- inhibit mast cell degran
moa-*Inhibit mast cell degranulation by preventing inc in intracellular Ca 2+ conc caused by the formation of IgE bridges
*Ophthalmic for allergy
Olopatadine
"olo"~"ojo" (eye in Spanish)

pharm- inhibit mast cell degran
Inhibitors of mast cell degranulation
adjunctive therapy for acute hypersensitivity rxns & for nausea & vomiting
H1-Receptor Blockers (Antihistamines)

“—amine”
Brompheniramine, po
Chlorpheniramine, po
Diphenhydramine, po

“—adine”
Fexofenadine, po
Desloratadine, po
Olopatadine, eye drops
Loratadine, po
Cyproheptadine, po

"--azine, “—izine”
Cetirizine, po
Meclizine, po
Hydroxyzine, po
Promethazine, IM or suppository

Dimenhydrinate, po

*Keeton: Never use H1 blockers to Tx otitis media
adjunctive therapy for acute hypersensitivity rxns & for nausea & vomiting IN TRUCK DRIVERS
the new antihistamine
-fexofenADINE
-loratADINE
-desloratADINE
-cetirizine
pharm effects of H1-blockers
*H1 receptor blockade:
-prevents constrictor response to histamine @ most smooth muscle (bronchial & GI)
-inhibit pain & itching caused by histamine at sensory nerve endings
-antagonize  in cap permeability

*Cholinergic muscarinic blockade:
-depresses CNS (sedation, etc)
-inhibits nasopharyngeal secretion
-prevents motion sickness (action in vestibular nuclei)

*Local anesthetic effect (diphenhydramine only!)

*Exerts antiemetic effect:
Promethazine
Hydroxyzine
Dimenhydrinate
Diphenhydramine
*Parkinson’s dz
diphenhydramine
*Prophylaxis for motion sickness

*Vertigo (Meniere’s dz)
dimenhydrinate
"2 men with vertigo"
*Seasonal & allergic rhinitis
Loratidine
Cetirizine
"Lora's cat (cet) has bad allergies"
*Treatment for motion sickness

*Pre-op sedation
*acute hypersensitivity rxns

*Allergic dermatoses

*motion sickness

*sedate anxious pts

*prevent post-op N/V

*N/V assoc w/ GI infection
Promethazine
*gastric & duodenal ulcers

*GERD

*prevent stress ulcers precipitated by severe trauma

*anaphylaxis

*viral warts & other skin lesions
Fomotidine

*Block H2 receptors
migraine headache
Use a "triptan"
(*sumatriptan, almotriptan)
Sumatriptan
moa-*selective agonist at 5HT 1B/1D receptors

*Migraine headaches
-Sumatriptan has short half life (2h) so HA may reoccur after single dose therapy

-if pts don’t respond well to initial dose, then giving more will not likely be beneficial

*Cluster HA
-Sumatriptan  severity of pain

-Sumatriptan decreases functional disability & decreases ipsilateral conjunctival injection
carcinoid syndrome
1.Cyproheptadine=DOC
pharm--GI hypermotility, hypersecretion &
Diarrhea
moa-*Blocker at 5HT1 & 5HT2 receptors

*Blocker at H1-histamine & muscarinic receptors

2. Octreotide
*somatostatin agonist-->Inhibits release of serotonin from tumor cells