Pharm His, Sero, Ergot 1-Liners

Front 1

Disease caused by excess ergot alkaloids

Back 1

St. Anthony's Fire

Front 2

Endogenous substances commonly interpreted as histamine, serotonin, prostaglandins, and vasoactive peptides

Back 2

Autocoids

Front 3

Distribution of histamine receptors H1, H2, and H3

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Smooth muscle; stomach, heart, and mast cells; nerve endings, CNS respectively

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Prototype antagonist of H1 and H2 receptors

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Diphenhydramine and cimetidine, respectively

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1st generation antihistamine that is highly sedating

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Diphendydramine

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1st generation antihistamine that is least sedating

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Chlorpheniramine or cyclizine

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2nd generation antihistamines

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Fexofenadine, loratadine, and cetirizine

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Generation of antihistamine that has the most CNS effects

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First generation due to being more lipidsoluble

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Major indication for H1 receptor antagonist

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Use in IgE mediated allergic reaction

Front 10

Antihistamine that can be used for anxiety and insomnia and is not addictive

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hydroxyzine (Atarax)

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H1 antagonist used in motion sickness

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Dimenhydrinate, meclizine, and other 1st generation

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Most common side effect of 1st generation antihistamines

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Sedation

Front 13

Lethal arrhythmias resulting from concurrent therapy with azole fungals (metabolized by CYP 3A4) and these antihistamines which inhibit the 3A4 isoenzyme.

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Terfenadine and astemizole (have been removed from the market)

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H2 blocker that causes the most interactions with other drugs

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Cimetidine

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Clinical use for H2 blockers

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Acid reflux disease, duodenal ulcer and peptic ulcer disease

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Receptors for serotonin (5HT-1) are located

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Mostly in the brain, and they mediate synaptic inhibition via increased K+ conductance

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5HT-1d agonist used for migraine headaches

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Sumatriptan, naratriptan, and rizatriptan

Front 18

Agents for reduction of postpartum bleeding

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Oxytocin, ergonovine and ergotamine

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5HT-3 antagonist used in chemotherapeutic induced emesis

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Ondansetron, granisetron, dolasetron and alosetron

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5HT-3 antagonist that has been associated with QRS and QTc prolongation and should not be used in patients with heart disease

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Dolasetron

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DOC to treat chemo-induced nausea and vomiting

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Odansetron

Front 22

Drug used in ergot alkaloids overdose, ischemia and gangrene

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Nitroprusside

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Reason ergot alkaloids are contraindicated in pregnancy

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Uterine contractions

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SE of ergot alkaloids

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Hallucinations resembling psychosis

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Ergot alkaloid used as an illicit drug

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LSD

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Peptide causing increased capillary permeability and edema

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Bradykinin and histamine

Front 27

Mediator of tissue pain, edema, inactivated by ACE, and may be a contributing factor to the development of angioedema

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Bradykinin

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Prostaglandins that cause abortions

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Prostaglandin E1 (misoprostol) PGE2, and PGF2alpha

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Difference between COX 1 and COX 2

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COX 1 is found throughout the body and COX 2 is only in inflammatory tissue

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Irreversible, nonselective COX inhibitor

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Aspirin

Front 31

Primary endogenous substrate for Nitric Oxidase Synthase

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Arginine

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MOA and effect of nitric oxide

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Stimulates cGMP which leads to vascular smooth muscle relaxation

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MOA of corticosteroids

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inhibit phospholipase A2