Pharm High Yield (Fa)

Front 1

cabamazepine toxicity

Back 1

hepatotoxicity

Front 2

effect of rifampin on estrogen

Back 2

rifampin caues an increase in estrogen metabolism in the liver (makes estrogen birth control less effective)

(induces CYP450)

Front 3

drugs with medium Vd distribute in the

Back 3

extracellular space

Front 4

drugs with high Vd distribute in the

Back 4

tissue

Front 5

Cl =

(2 equations)

Back 5

Cl = rate of drug elimination/plasma concentration(Cp)

Cl = Vd x Ke

Front 6

overdose of weak base treated with

Back 6

ammonium chloride

(weak bases get trapped in acidic environments because they accept a proton)

Front 7

NT that activates renal vascular smooth muscle

branch of ANS

Back 7

DA

sympathetic

Front 8

Receptors and G-protein class

Back 8

α1 - q
α2 - i
β1 - s
β2 - s
M1 - q
M2 - i
M3 - q
D1 - s
D2 - i
H1 - q
H2 - s
V1 - q
V2 - s

Kiss (qiss) Kick (qiq) until you're Sick (siq) of Sex (sqs)

Front 9

decreased insulin release caused by stimulation of

Back 9

α2

Front 10

increased renin release caused by stimulation of

Back 10

β1

Front 11

increased lipolysis caused by stimulation of

Back 11

β1

Front 12

increased aqueous humor formation caused by stimulation of

Back 12

β1

Front 13

vasodilation caused by stimulation of

Back 13

β2

Front 14

increased release of glucagon caused by stimulation of

Back 14

β2

Front 15

relaxation of renal vascular smooth muscle caused by stimulation of

Back 15

D1

Front 16

NT release by the brain caused by stimulation of

Back 16

D2

Front 17

contraction of bronchioles caused by stimulation of

Back 17

H1

Front 18

increased vascular smooth muscle contraction is caused by stimulation of

Back 18

V1

Front 19

Gq pathway

Back 19

PLC --> PIP2 --> IP3 + DAG --> Ca2+

Front 20

function of IP3

Back 20

increases influx of Ca2+

Front 21

function of DAG

Back 21

stimulates PKC

Front 22

cAMP stimulates

Back 22

PKA

Front 23

choline uptake into presynaptic nerve terminals is inhibited by

Back 23

hemicholinium

Front 24

packaging of ACh into presynaptic vessicles is inhibited by

Back 24

vasamicol

Front 25

conversion of tyrosine to DOPA is inhibited by

Back 25

metyrosine

Front 26

entrance of DA into presynaptic vessicle is inhibited by

Back 26

reserpine

Front 27

release of NE from presynaptic nerve terminals in inhibited by

Back 27

guanethidine

Front 28

release of NE from presynaptic nerve terminals is stimulated by (2)

Back 28

amphetamine

ephedrine

Front 29

uptake of NE by presynaptic nerve terminals is inhibited by (2)

Back 29

cocaine

TCA's

Front 30

receptors found on presynaptic adrenergic nerve terminals (3)

Back 30

M1
Angiotensin II
α2 (serves as negative feedback)

Front 31

cholinomimetics:

direct agonists (4)

Back 31

bethanechol
carbachol
pilocarpine
methacholine

Front 32

direct-acting cholinomimetic used to treat postoperative and neurogenic ileus and urinary retention

Back 32

bethanechol

Front 33

direct-acting cholinomimetic used to treat glaucoma

MOA (2)
- open angle glaucoma
- narrow angle glaucoma

Back 33

carbachol

open angle:

contraction of ciliary muscle --> ↑ aqueous humor outflow --> ↓ IOP

narrow angle:

contraction of pupillary sphincter --> ↑ aqueous humor outflow --> ↓ IOP

Front 34

direct-acting cholinomimetic that causes perspiration, lacrimation, and salivation

Back 34

pilocarpine

Front 35

direct-acting cholinomimetic used in the challenge test for diagnosis of asthma

MOA

Back 35

methacholine

stimulates muscarinic receptors located in the airway --> bronchoconstriction

Front 36

cholinomimetics:

indirect agonists (5)

Back 36

neostigmine
pyridostigmine
physostigmine
edrophonium
echothiophate

Front 37

neostigmine is used to treat (3)

Back 37

postoperative and neurogenic ileus and urinary retention
myasthenia gravis
reversal of NMJ blockade

Front 38

neostigmine has no

Back 38

CNS penetration

Front 39

pyridostigmine is used to treat

Back 39

myasthenia gravis

Front 40

T/F pyridostigmine penetrates the CNS

Back 40

true

Front 41

physostigmine is used to treat (2)

Back 41

glaucoma (crosses BBB)

atropine OD

Front 42

echothiophate is used to treat

Back 42

glaucoma

Front 43

cholinergic receptor blockers (7)

Back 43

atropine
benztropine
scopolamine
tropicamide
ipratropium
oxybutin
glycopyrrolate

Front 44

cholinergic receptor blockers that causes mydriasis and cycloplegia (2)

Back 44

atropine

tropicamide

Front 45

benztropine is used to treat

Back 45

PD

Front 46

methscopolamine is used to treat

Back 46

urgency in mild cystitis and bladder spasms

Front 47

oxybutin is used to treat

Back 47

urgency in mild cystitis and bladder spasms

Front 48

glycopyrrolate is used to

Back 48

urgency in mild cystitis and bladder spasms

Front 49

airway secretions are decreased by

Back 49

atropine

Front 50

can cause acute angle-closure glaucoma in the elderly

Back 50

atropine

Front 51

can cause urinary retention in men with prostatic hypertrophy

Back 51

atropine

Front 52

can cause hyperthermia in infants

Back 52

atropine

Front 53

hexamtheonium is used in experimental models to

Back 53

prevent vagal reflex responses to changes in blood pressure

(prevents reflex bradycardia caused by NE release)

Front 54

epinephrine

Back 54

α1
α2
β1
β2

Front 55

low-dose Epi is selective for

Back 55

β1

Front 56

norepinephrine

Back 56

α1
α2
β1 (minor)

Front 57

isoproterenol

Back 57

β1
β2

Front 58

DA

Back 58

D1
D2

Front 59

DA is used to treat (2)

Back 59

shock (increases renal perfusion)

heart failure

Front 60

dobutamine

Back 60

β1
β2 (minor)

Front 61

ephedrine is used to treat (2)

Back 61

nasal congestion

urinary incontinence

Front 62

phenylephrine

Back 62

α1
α2 (minor)

Front 63

albuterol

Back 63

β1 (minor)
β2

Front 64

terbutaline

Back 64

β1 (minor)
β2

Front 65

α-methyldopa

Back 65

α2

Front 66

clonidine and α-methyldopa are used to treat

Back 66

hypertension in pts. with renal disease (do not cause a decrease in renal blood flow)

Front 67

change in PP with Epi

Back 67

very wide PP

α1 causes SBP to increase
β2 causes DBP to decrease

Front 68

isoproterenol:

change in BP

Back 68

decreased DBP (β2)

Front 69

phenoxybenzamine

reversible?

Back 69

blocks α1 and α2

no

Front 70

phenoxybenzamine is used to treat

Back 70

pheochromocytoma

Front 71

phentolamine

reversible?

Back 71

blocks α1 and α2

yes

Front 72

"-azosin" toxicity

Back 72

1st-dose orthostatic hypotension

Front 73

mirtazapine

Back 73

blocks α2

Front 74

mirtazapine is used to treat

Back 74

depression

Front 75

mirtazapine toxicities (2)

Back 75

increased serum cholesterol

increased appetite

Front 76

β-blockers vs. renin secretion

Back 76

β-blockers cause a decrease in renin secretion by blocking β1

Front 77

β-blockers decrease mortality assocaited with

Back 77

MI's

Front 78

β-blockers slow progression of

Back 78

CHF

Front 79

timolol is used to treat

Back 79

glaucoma

Front 80

selective, i.e., β1, β-blockers

Back 80

A --> M

Front 81

nonselective β-blockers

Back 81

N --> Z

Front 82

types of drugs used to treat glaucoma (5)

Back 82

α-agonists
β-blockers
diuretics
cholinomimetics
prostaglandin analogs

Front 83

α-agonists used to treat glaucoma (2)

Back 83

epinephrine

brimonindine

Front 84

MOA of epinephrine in treating glaucoma

Back 84

increases outflow of aqueous humor

Front 85

MOA of brimonidine in treating glaucoma

Back 85

decreases production of aqueous humor

Front 86

MOA of β-blockers in treating glaucoma

Back 86

decrease production of aqueous humor

Front 87

diuretic used to treat glaucoma

Back 87

acetazolamide

Front 88

MOA of acetazolamide in treating glaucoma

Back 88

decrease production of aqueous humor due to a decrease in bicarbonate

Front 89

MOA's of cholinomimetics in treating glaucoma (3)

Back 89

increase outflow of aqueous humor

contract ciliary muscle --> open trabecular meshwork

open canal of Schlemm

Front 90

cholinomimetic used in treating glaucoma emergencies

Back 90

pilocarpine

Front 91

prostaglandin analog used to treat glaucoma

Back 91

latanoprost (PGF2α)

Front 92

MOA of latanoprost

Back 92

increase outflow of aqueous humor

Front 93

latanoprost toxicity

Back 93

darkens color of iris ("browning")