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8 Cards in this Set
- Front
- Back
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Heparin
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MOA: activates antithrombin III (II, X)
use: follow PTT; can use in pregnancy tox: bleeding, HIT (heparin binds to plts), osteoporosis reversal: protamine sulfate |
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enoxaparin
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MOA: LMWH (acts more on X)
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Lepirudin
Bivalirudin |
MOA: direct thrombin inhibitors
use: pts with h/o HIT |
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Warfarin
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MOA: prevents gamma-carbox of II, VII, IX, X, protein C, protein S (acts at liver)
use: chronic anticoagulation; NOT for pregnancy; follow PT/INR tox: bleeding, teratogen, skin/tissue necrosis reversal: IV vit K and FFP |
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Streptokinase
Urokinase tPA (alteplase) APSAC (anistreplase) |
MOA: helps plasminogen --> plasmin
use: early MI/ischemi stroke; increased Pt/PTT tox: bleeding reersal: aminocaproic acid (inhibits fibrinolysis) |
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ASA
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MOA: irreversible acetylation of COX (prevents arachidonic acid conversion to TXA2)
tox: gastric ulcer, bleeding, hyperventilation, Reye's, tinnitus (CN VIII) |
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Clopidogrel
Ticlopidine |
MOA: irreversible block of ADP receptors; thus no glycoprotein IIb/IIIa expression; can't bind to fibrinogen
use: ACS, stenting tox: neutropenia for ticlopidine |
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Abciximab
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MOA: monoclonal ab binding to glycoprotein IIb/IIIa on activated plts
use: ACS, PTCA tox: bleeding, thrombocytopenia |
